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2011 | 71 | 1 |
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Searching for oligodendrocyte precursors for cell replacement therapies

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Inherited or acquired oligodendrocyte deficiency or abnormalities usually lead to severe neurological disorders, common in humans and animals. The wide spectrum of diseases to be treated, their frequency and lack of effective treatments result in an urgent need to elaborate alternative options such as cell replacement therapies. Elaborating the protocols for the efficient oligodendrocyte progenitor cell (OPC) generation for neurorestrative purposes still meets the essential obstacles. Searching for the most convenient, accessible and rich sources of stem-like cells is the first of them. The immunological barrier is another problem, which could however be solved by usage of either the allo- or the autografts and the pure, xeno-free compounds for the cell propagation. The third criterion is the efficiency of the progenitor derivation, proliferation and purification. The effective cellular replacement experiments carried on animal models of congenital and acquired neurodegenerative disease approached their translation into clinical practice. Notwithstanding due to urgent need for treatment of a broad spectrum of traumas and neurodegenerative disorders accompanied by hypo/demyelination, different cell sources and alternative strategies should necessarily be tested to expand the treatment options.
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  • NeuroRepair Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
  • Aharonowiz M, Einstein O, Fainstein N, Lassmann H, Reubinoff B, Ben-Hur T (2008) Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis. PLoS One 5: e3145.
  • Aguirre A, Gallo V (2004) Postnatal neurogenesis and glio- genesis in the olfactory bulb from NG2-expressing pro­genitors of the subventricular zone. J Neurosci 17: 10530-10541.
  • Ali H, Bahbahani H (2010) Umbilical cord blood stem cells - potential therapeutic tool for neural injuries and disor­ders. Acta Neurobiol Exp (Wars) 70: 316-324. Amarilglio N, Hirshberg A, Scheithauer BW, Loewenthal R, Trakhtenbrot L, Paz N, Koren-Michowitz M, Waldman D, Leider-Trejo L, Toren A, Constantini S, Rechavi G (2009) Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med 17: e1000029.
  • Artandi SE, DePinho RA (2010) Telomeres and telomerase in cancer. Carcinogenesis. 31: 9-18.
  • Assanah M, Lochhead R, Ogden A, Bruce J, Goldman J, Canoll P (2006) Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J Neurosci 21: 6781-6790.
  • Back SA, Gan X, Li Y, Rosenberg PA, Volpe JJ (1998) Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. J Neurosci 15: 6241-6253.
  • Baron W, Shattil SJ, ffrench-Constant C (2002) The oligo­dendrocyte precursor mitogen PDGF stimulates prolifera­tion by activation of alpha(v)beta3 integrins. EMBO J 15: 1957-1966.
  • Belachew S, Chittajallu R, Aguirre AA, Yuan X, Kirby M, Anderson S, Gallo V (2003) Postnatal NG2 proteoglycan- expressing progenitor cells are intrinsically multipotent and generate functional neurons. J Cell Biol 14: 169-186.
  • Ben-Hur T, Rogister B, Murray K, Rougon G, Dubois-Dalcq M (1998) Growth and fate of PSA-NCAM+ precursors of the postnatal brain. J Neurosci 1: 5777-5788.
  • Bongarzone ER (2002) Induction of oligodendrocyte fate during the formation of the vertebrate neural tube. Neurochem Res 27: 1361-1369.
  • Boue S, Paramonov I, Barrero MJ, Izpisua Belmonte JC (2010) Analysis of human and mouse reprogramming of somatic cells to induced pluripotent stem cells. What is in the plate? PLoS One 17: e12664.
  • Broughton SK, Chen H, Riddle A, Kuhn SE, Nagalla S, Roberts CT Jr, Back SA (2007) Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transduction. J Neurochem 100: 628-638.
  • Buzanska L, Sypecka J, Nerini-Molteni S, Compagnoni A, Hogberg HT, del Torchio R, Domanska-Janik K, Zimmer J, Coecke S (2009) A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system. Stem Cells 27: 2591-2601.
  • Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA (2008) A tran- scriptome database for astrocytes, neurons, and oligoden- drocytes: a new resource for understanding brain devel­opment and function. J Neurosci 2: 264-278.
  • Chua SJ, Bielecki R, Wong CJ, Yamanaka N, Rogers IM, Casper RF (2009) Neural progenitors, neurons and oligo- dendrocytes from human umbilical cord blood cells in a serum-free, feeder-free cell culture. Biochem Biophys Res Commun 6: 217-221.
  • Cizkova D, Cizek M, Nagyova M, Slovinska L, Novotna I, Jergova S, Radonak J, Hlucilova J, Vanicky I (2009) Enrichment of rat oligodendrocyte progenitor cells by magnetic cell sorting. J Neurosci Methods 184: 88-94.
  • Deda H, Inci MC, Kurekgi AE, Sav A, Kayihan K, Ozgun E, Ustunsoy GE, Kocabay S (2009) Treatment of amyo- trophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Cytotherapy 11: 18-25.
  • Einstein O, Friedman-Levi Y, Grigoriadis N, Ben-Hur T (2009) Transplanted neural precursors enhance host brain-derived myelin regeneration. J Neurosci 29: 15694­15702.
  • Fernandez M, Pirondi S, Manservigi M, Giardino L, Calza L (2004) Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. Eur J Neurosci 20: 2059-2070.
  • Fu SL, Hu JG, Li Y, Wang YX, Jin JQ, Xui XM, Lu PH (2007) A simplified method for generating oligodendro- cyte progenitor cells from neural precursor cells isolated from the E16 rat spinal cord.Acta Neurobiol Exp (Wars) 67: 367-377.
  • Gard AL, Pfeiffer SE (1993) Glial cell mitogens bFGF and PDGF differentially regulate development of O4+GalC- oligodendrocyte progenitors. Dev Biol 159: 618-630.
  • Garwood J, Garcion E, Dobbertin A, Heck N, Calco V, ffrench-Constant C, Faissner A (2004) The extracellular matrix glycoprotein Tenascin-C is expressed by oligoden- drocyte precursor cells and required for the regulation of maturation rate, survival and responsiveness to platelet- derived growth factor. Eur J Neurosci 20: 2524-2540.
  • Geffner LF, Santacruz P, Izurieta M, Flor L, Maldonado B, Auad AH, Montenegro X, Gonzalez R, Silva F (2008) Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies. Cell Transplant 17: 1277-1293.
  • Grinspan J (2002) Cells and signaling in oligodendrocyte development. J Neuropathol Exp Neurol 61: 297-306.
  • Gu J, Royland JE, Wiggins RC, Konat GW (1997) Selenium is required for normal upregulation of myelin genes in differentiating oligodendrocytes. J Neurosci Res 47: 626-635.
  • Hermann A, Gastl R, Liebau S, Popa MO, Fiedler J, Boehm BO, Maisel M, Lerche H, Schwarz J, Brenner R, Storch
  • A (2004) Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells. J Cell Sci 117: 4411-4422
  • Hu BY, Du ZW, Zhang SC (2009) Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc 4: 1614-1622.
  • Izrael M, Zhang P, Kaufman R, Shinder V, Ella R, Amit M, Itskovitz-Eldor J, Chebath J, Revel M (2007) Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci 34: 310­323.
  • Jablonska A, Kozlowska H, Markiewicz I, Domanska-Janik K, Lukomska B (2010) Transplantation of neural stem cells derived from human cord blood to the brain of adult and neonatal rats. Acta Neurobiol Exp (Wars) 70: 337­350.
  • Jana M, Jana A, Pal U, Pahan KA (2007) simplified method for isolating highly purified neurons, oligodendrocytes, astrocytes, and microglia from the same human fetal brain tissue. Neurochem Res 32: 2015-2022.
  • Jang S, Cho HH, Cho YB, Park JS, Jeong HS (2010) Functional neural differentiation of human adipose tissue- derived stem cells using bFGF and forskolin. BMC Cell Biol 6: 25.
  • Kang KS, Kim SW, Oh YH, Yu JW, Kim KY, Park HK, Song CH, Han H (2005) A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy 7: 368-373.
  • Kennea NL, Waddington SN, Chan J, O'Donoghue K, Yeung D, Taylor DL, Al-Allaf FA, Pirianov G, Themis M, Edwards AD, Fisk NM, Mehmet H (2009) Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype.Cell Cycle 8: 1069-1079.
  • Kerr CL, Letzen BS, Hill CM, Agrawal G, Thakor NV, Sterneckert JL, Gearhart JD, All AH (2010) Efficient dif­ferentiation of human embryonic stem cells into oligo- dendrocyte progenitors for application in a rat contusion model of spinal cord injury. Int J Neurosci 120: 305­313.
  • Kim D, Kim CH, Moon JI, Chung YG, Chang MY, Han BS, Ko S, Yang E, Cha KY, Lanza R, Kim KS (2009) Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 4: 472-476.
  • Larsen PH, Yong VW (2004) The expression of matrix metalloproteinase-12 by oligodendrocytes regulates their maturation and morphological differentiation. J Neurosci 24: 7597-7603.
  • Larsen PH, DaSilva AG, Conant K, Yong VW (2006) Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice. J Neurosci 26: 2207-2214.
  • Lee KH, Suh-Kim H, Choi JS, Jeun SS, Kim EJ, Kim SS, Yoon do H, Lee BH (2007) Human mesenchymal stem cell transplantation promotes functional recovery follow­ing acute spinal cord injury in rats. Acta Neurobiol Exp (Wars) 67: 13-22.
  • Letzen BS, Liu C, Thakor NV, Gearhart JD, All AH, Kerr CL (2010) MicroRNA expression profiling of oligodendro- cyte differentiation from human embryonic stem cells. PLoS One 5: e10480.
  • Li F, He Z, Shen J, Huang Q, Li W, Liu X, He Y, Wolf F, Li CY (2010) Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell 4: 508­520.
  • Liang P, Jin LH, Liang T, Liu EZ, Zhao SG (2006) Human neural stem cells promote corticospinal axons regenera­tion and synapse reformation in injured spinal cord of rats. Chin Med J (Engl) 119: 1331-1338.
  • Luo YC, Zhang HT, Cheng HY, Yang ZJ, Dai YW, Xu RX (2010) Differentiation of cryopreserved human umbilical cord blood-derived stromal cells into cells with an oligo- dendrocyte phenotype. In Vitro Cell Dev Biol Anim 46: 585-589.
  • Maric D, Maric I, Chang YH, Barker JL (2003) Prospective cell sorting of embryonic rat neural stem cells and neu­ronal and glial progenitors reveals selective effects of basic fibroblast growth factor and epidermal growth factor on self-renewal and differentiation. J Neurosci 23: 240-251.
  • McCarthy K, deVellis J (1980) Preparation of separate astro- glial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85: 890-902.
  • Nagaoka M, Si-Tayeb K, Akaike T, Duncan SA (2010) Culture of human pluripotent stem cells using completely defined conditions on a recombinant E-cadherin substra- tum.BMC Dev Biol 2: 10-60.
  • Neri M, Maderna C, Ferrari D, Cavazzin C, Vescovi AL, Gritti A (2010) Robust generation of oligodendrocyte progenitors from human neural stem cells and engraft- ment in experimental demyelination models in mice. PLoS One 5: e10145.
  • Nielsen JA, Maric D, Lau P, Barker JL, Hudson LD (2006) Identification of a novel oligodendrocyte cell adhesion protein using gene expression profiling. J Neurosci 26: 9881-9891.
  • Ogawa S, Tokumoto Y, Miyake J, Nagamune T (2011) Immunopanning selection of A2B5-positive cells increased the differentiation efficiency of induced pluri­potent stem cells into oligodendrocytes. Neurosci Lett. 489: 79-83.
  • Poltavtseva RA, Marey MV, Aleksandrova MA, Revishchin AV, Korochkin LI, Sukhikh GT (2002) Evaluation of pro­genitor cell cultures from human embryos for neurotrans­plantation. Brain Res Dev Brain Res 134: 149-154.
  • Rajala K, Lindroos B, Hussein SM, Lappalainen RS, Pekkanen-Mattila M, Inzunza J, Rozell B, Miettinen S, Narkilahti S, Kerkelä E, Aalto-Setälä K, Otonkoski T, Suuronen R, Hovatta O, Skottman H (2010) A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells. PLoS One 5: e10246.
  • Salazar DL, Uchida N, Hamers FP, Cummings BJ, Anderson AJ (2010) Human neural stem cells differentiate and pro­mote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One 5: e12272.
  • Sandrock RW, Wheatley W, Levinthal C, Lawson J, Hashimoto B, Rao M, Campanelli JT (2010) Isolation, characterization and preclinical development of human glial-restricted progenitor cells for treatment of neuro­logical disorders. Regen Med 5: 381-394.
  • Schoonover CM, Seibel MM, Jolson DM, Stack MJ, Rahman RJ, Jones SA, Mariash CN, Anderson GW (2004) Thyroid hormone regulates oligodendrocyte accu­mulation in developing rat brain white matter tracts. Endocrinology 145: 5013-5020.
  • Shankar SL, O'Guin K, Cammer M, McMorris FA, Stitt TN, Basch RS, Varnum B, Shafit-Zagardo B (2003) The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphati- dylinositol 3-kinase-dependent pathway. J Neurosci 23: 4208-4218.
  • Sharp J, Frame J, Siegenthaler M, Nistor G, Keirstead HS (2010) Human embryonic stem cell-derived oligodendro- cyte progenitor cell transplants improve recovery after cervical spinal cord injury. Stem Cells 28:152-63
  • Sundberg M, Skottman H, Suuronen R, Narkilahti S (2010) Production and isolation of NG2+ oligodendrocyte pre­cursors from human embryonic stem cells in defined serum-free medium. Stem Cell Res 5: 91-103.
  • Sykova E, Homola A, Mazanec R, Lachmann H, Konradova SL, Kobylka P, Padr R, Neuwirth J, Komrska V, Vavra V, et al (2006) Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplant 15: 675-687.
  • Sypecka J, Sarnowska A, Domanska-Janik K (2009a) Crucial role of the local micro-environment in fate deci­sion of neonatal rat NG2 progenitors. Cell Prolif 42: 661-671.
  • Sypecka J, Dragun-Szymczak P, Zalewska T, Domanska- Janik K (2009b) Laminin promotes oligogliogenesis and increases MMPs activity in human neural stem cells of HUCB-NSC line. Acta Neurobiol Exp (Wars) 69: 37-45.
  • Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, Fiebig-Comyn A, Levadoux-Martin M, Bhatia M (2010) Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 25: 521-526.
  • Tokumoto Y, Ogawa S, Nagamune T, Miyake J (2010) Comparison of efficiency of terminal differentiation of oligodendrocytes from induced pluripotent stem cells versus embryonic stem cells in vitro. J Biosci Bioeng 109: 622-628.
  • Tracy E, Aldrink J, Panosian J, Beam D, Thacker J, Reese M, Kurtzberg J (2008) Isolation of oligodendrocyte-like cells from human umbilical cord blood. Cytotherapy 10: 518-525.
  • Trotter J, Schachner M (1989) Cells positive for O4 surface antigen isolated by cell sorting are able to differentiate into astrocytes or oligodendrocytes. Dev Brain Res 46: 115-122.
  • Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, Kumagai G, Nishino M, Tomisato S, Higashi H, Nagai T, Katoh H, Kohda K, Matsuzaki Y, Yuzaki M, Ikeda E, Toyama Y, Nakamura M, Yamanaka S, Okano H (2010) Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci USA 107: 12704-12709.
  • Uhm JH, Dooley NP, Oh LY, Yong VW (1998) Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracel­lular matrix. Glia 22: 53-63.
  • Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M (2010)Direct conversion of fibroblasts to functional neurons by defined factors. Nature 25:1035­1041
  • Warrington AE, Baibarese E, Pfeiffer SE (1992) Stage spe­cific, (O4+GalC-) isolated oligodendrocyte progenitors produce MBP+ myelin in vivo. Dev Neurosci 14: 93-97.
  • Windrem MS, Nunes MC, Rashbaum WK, Schwartz TH, Goodman RA, McKhann G 2nd, Roy NS, Goldman SA (2004) Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nat Med 10: 93-97.
  • Watkins TA, Barres BA (2002) Integrins as developmental switches. Nat Cell Biol 4: E253-E255.
  • Xie X, Hiona A, Lee AS, Cao F, Huang M, Li Z, Cherry A, Pei X, Wu JC (2011) Effects of long-term culture on human embryonic stem cell aging. Stem Cells Dev 20: 127-138.
  • Zhang PL, Izrael M, Ainbinder E, Ben-Simchon L, Chebath J, Revel M (2006) Increased myelinating capacity of embryonic stem cell derived oligodendro- cyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein. Mol Cell Neurosci 31: 387-398
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