Modulation of the human preadipocyte mitochondrial activity by beta-carotene

• Autorzy: Sliwa A. , Goralska J. , Czech U. , Gruca A. , Polus A. , Zapala B. , Dembinska-Kiec A.
• Języki publikacji: EN

Abstrakty

EN

 Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 1
• Opis fizyczny: p.39-41,fig.,ref.

Twórcy

autor

Sliwa A.

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland

autor

Goralska J.

autor

Czech U.

autor

Gruca A.

autor

Polus A.

autor

Zapala B.

autor

Dembinska-Kiec A.

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