A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein

• Autorzy: Shahid M. , Manchi G. , Slunsky P. , Naseer O. , Fatima A. , Leo B. , Raila J.
• Języki publikacji: EN

Abstrakty

EN

Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases. This review deliberates our current findings of how the components of ECM change at the molecular level during disease progression in canine OA.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2017
• Tom: 20
• Numer: 1
• Opis fizyczny: p.189-201,ref.

Twórcy

autor

Shahid M.

• Faculty of Veterinary Medicine, Small Animal Clinic, Free University, Berlin, Germany

autor

Manchi G.

• Faculty of Veterinary Medicine, Small Animal Clinic, Free University, Berlin, Germany

autor

Slunsky P.

• Faculty of Veterinary Medicine, Small Animal Clinic, Free University, Berlin, Germany

autor

Naseer O.

• Department of Clinical Medicine and Surgery, Factulty of Veterinary Sciences, UVAS, Lahore, Pakistan

autor

Fatima A.

• International Medical School, Tianjin Medical University, Tanjin, China

autor

Leo B.

• Faculty of Veterinary Medicine, Small Animal Clinic, Free University, Berlin, Germany

autor

Raila J.

• Institut fur Ernahrungswissenschaft, University of Potsdam, 14558 Nuthetal OT Bergholz-Rehbrucke, Germany

Bibliografia

• Andersson M, Petersson I, Karlsson K, Jonsson EN, Mänsson B, Heinegärd D, Saxne T (2006) Diurnal variation in serum levels of cartilage oligomeric matrix protein in patients with knee osteoarthritis or rheumatoid arthritis. Ann Rheum Dis 65: 1490-1494.
• Arner EC (2002) Aggrecanase-mediated cartilage degradation. Curr Opin Pharmacol 2: 322-329.
• Bager C, Gudmann N, Willumsen N, Leeming D, Karsdal M, Bay-Jensen A, Høgdall E, Balslev I, He Y (2016) Quantification of fibronectin as a method to assess ex vivo extracellular matrix remodeling. Biochem Biophys Res Commun 478: 586-591.
• Bao JP, Chen WP, Wu L (2011) Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis. Mol Biol Rep 38: 2879-2885.
• Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, Mitchell P, Hambor J, Diekmann O, Tschesche H (1997) Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 99: 1534-45.
• Boland L, Danger R, Cabon Q, Rabillard M, Brouard S, Bouvy B, Gauthier O (2014) MMP-2 as an early synovial biomarker for cranial cruciate ligament disease in dogs. Vet Comp Orthop Traumatol 27: 210-215.
• Budsberg SC, Lenz ME, Thonar EJA (2006) Serum and synovial fluid concentrations of keratan sulfate and hyaluronan in dogs with induced stifle joint osteoarthritis following cranial cruciate ligament transection. Am J Vet Res 67: 429-432.
• Carlson CS, Guilak F, Vail TP, Gardin JF, Kraus VB (2002) Synovial fluid biomarker levels predict articular cartilage damage following complete medial meniscectomy in the canine knee. J Orthop Res 20: 92-100.
• Choi-Miura NH, Saito K, Takahashi K, Yoda M, Tomita M (2001) Regulation mechanism of the serine protease activity of plasma hyaluronan binding protein. Biol Pharm Bull 24: 221-225.
• Chu Q, Lopez M, Hayashi K, Ionescu M, Billinghurst R, Johnson K, Poole A, Markel M (2002) Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog. Osteoarthritis Cartilage 10: 662-669.
• Chu X, Wang J, Dou L, Zhao G (2015) Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model. Genet Mol Res 14: 14207-14215.
• Chung L, Dinakarpandian D, Yoshida N, Lauer-Fields JL, Fields GB, Visse R, Nagase H (2004) Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. EMBO J 23: 3020-3030.
• Clements DN, Fitzpatrick N, Carter SD, Day PJ (2009) Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritis. Vet J 179: 211-218.
• Connor J, LePage C, Swift B, Yamashita D, Bendele A, Maul D, Kumar S (2009) Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis. Osteoarthritis Cartilage 17: 1236-1243.
• Cook J, Kuroki K, Visco D, Pelletier JP, Schulz L, Lafeber F (2010) The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the dog. Osteoarthritis Cartilage 18: S66-S79.
• De Rooster H, Cox E, Bree HV (2000) Prevalence and relevance of antibodies to type-I and-II collagen in synovial fluid of dogs with cranial cruciate ligament damage. Am J Vet Res 61: 1456-1461.
• Echigo R, Mochizuki M, Nishimura R, SasakI N (2006) Suppressive Effect of Hyaluronan on Chondrocyte Apoptosis in Experimentally Induced Acute Ostaoarthritis in Dogs. J Vet Med Sci 68: 899-902.
• Elsaid K, Jay G, Warman M, Rhee D, Chichester C (2005) Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum 52: 1746-1755.
• Engströum-Laurent A, Hällgren R (1987) Circulating hyaluronic acid levels vary with physical activity in healthy subjects and in rheumatoid arthritis patients. Relationship to synovitis mass and morning stiffness. Arthritis Rheum 30: 1333-1338.
• Estrella R, Whitelock J, Packer N, Karlsson N (2010) The glycosylation of human synovial lubricin: implications for its role in inflammation. Biochem J 429: 359-367.
• Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermúdez MA, Blanchet T, Gleghorn JP, Bonassar LJ, Bendele AM (2009) Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum 60: 840-847.
• Fujiki M, Shineha J, Yamanokuchi K, Misumi K, Sakamoto H (2007) Effects of treatment with polysulfated glycosaminoglycan on serum cartilage oligomeric matrix protein and C-reactive protein concentrations, serum matrix metalloproteinase-2 and-9 activities, and lameness in dogs with osteoarthritis. Am J Vet Res 68: 827-833.
• Gharbi M, Sanchez C, Mazzucchelli G, De Pauw E, Henrotin Y (2013) Identification of differential pattern of protein expression in canine osteoarthritis serum after anterior cruciate ligament transection: a proteomic analysis. Vet J 197: 848-853.
• Gibson BG, Briggs MD (2016) The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases. Orphanet J Rare Dis 11: 86.
• Girling S, Bell S, Whitelock R, Rayward R, Thomson D, Carter S, Vaughan-Thomas A, Innes J (2006) Use of biochemical markers of osteoarthritis to investigate the potential disease-modifying effect of tibial plateau levelling osteotomy. J Small Anim Pract 47: 708-714.
• Golightly YM, Marshall SW, Kraus VB, Renner JB, Villaveces A, Casteel C, Jordan JM (2011) Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms? Arthritis Rheum 63: 2276-2283.
• Goranov NV (2007) Serum markers of lipid peroxidation, antioxidant enzymatic defense, and collagen degradation in an experimental (Pond-Nuki) canine model of osteoarthritis. Vet Clin Pathol 36: 192-195.
• Hayashi K, KIM SY, Lansdowne JL, Kapatkin A, Dejardin LM (2009) Evaluation of a collagenase generated osteoarthritis biomarker in naturally occurring canine cruciate disease. Vet Surg 38: 117-121.
• Hegemann N, Kohn B, Brunnberg L, Schmidt M (2002) Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders. Osteoarthritis Cartilage 10: 714-721.
• Hegemann N, Wondimu A, Ullrich K, Schmidt MF (2003) Synovial MMP-3 and TIMP-1 levels and their correlation with cytokine expression in canine rheumatoid arthritis. Vet Immunol Immunopathol 91: 199-204.
• Henrotin Y, Addison S, Kraus V, Deberg M (2007) Type II collagen markers in osteoarthritis: what do they indicate? Curr Opin Rheumatol 19: 444-450.
• Henrotin Y, Martel-Pelletier J, Msika P, Guillou G, Deberg M (2012) Usefulness of specific OA biomarkers, Coll2-1 and Coll2-1NO 2, in the anterior cruciate ligament OA canine model. Osteoarthritis Cartilage 20: 787-790.
• Hunter DJ, Li J, LaValley M, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D (2007) Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study. Arthritis Res Ther 9: R108.
• Hurlbeck C, Einspanier R, Pfeil I, Bondzio A (2014) Evaluation of biomarkers for osteoarthritis caused by fragmented medial coronoid process in dogs. Res Vet Sci 96: 429-435.
• Innes JF, Little CB, Hughes CE, Caterson B (2005) Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early-and late-stage osteoarthritis. Am J Vet Res 66: 1679-1685.
• Iovu M, Dumais G, Du Souich P (2008) Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 16: S14-S18.
• Jay GD, Elsaid KA, Zack J, Robinson K, Trespalacios F, Cha CJ, Chichester CO (2004) Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis. J Rheumatol 31: 557-564.
• Johnson KA, Hart RC, Chu Q, Kochevar D, Hulse DA (2001) Concentrations of chondroitin sulfate epitopes 3B3 and 7D4 in synovial fluid after intra-articular and extracapsular reconstruction of the cranial cruciate ligament in dogs. Am J Vet Res. 62: 581-587.
• Johnson KA, Hay CW, Chu Q, Roe SC, Caterson B (2002) Cartilage-derived biomarkers of osteoarthritis in synovial fluid of dogs with naturally acquired rupture of the cranial cruciate ligament. Am J Vet Res 63: 775-781.
• Jones AR, Chen S, Chai DH, Stevens AL, Gleghorn JP, Bonassar LJ, Grodzinsky AJ, Flannery CR (2009) Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum 60: 133-142.
• Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank S, Edwards DR, Parker AE, Clark IM (2004) Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis Rheum. 50: 131-141.
• Konttinen YT, Mandelin J, Li TF, Salo J, Lassus J, Liljestrom M, Hukkanen M, Takagi M, Virtanen I, Santavirta S (2002) Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. Arthritis Rheum 46: 953-960.
• Kosinska MK, Ludwig TE, Liebisch G, Zhang R, Siebert HC, Wilhelm J, Kaesser U, Dettmeyer RB, Klein H, Ishaque B (2015) Articular joint lubricants during osteoarthritis and rheumatoid arthritis display altered levels and molecular species. PLoS One 10: e0125192.
• Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, Gardiner J, Garnero P, Hardin J, Henrotin Y (2011) Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage 19: 515-542.
• Li Z, Cao L, Wang S (2009). Effect of moxibustion in treating knee joint osteoarthritis and its relation with contents of hyaluronic acid in serum and synovial fluid. Zhongguo Zhong Xi Yi Jie He Za Zhi 29:883-885.
• Lindhorst E, Vail T, Guilak F, Wang H, Setton L, Vilim V, Kraus V (2000) Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis. J Orthop Res 18: 269-280.
• Little CB, Hughes CE, Curti CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otternes IG, Flannery CR (2002) Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix Biol 21: 271-288.
• Liu W, Burton-Wurster N, Glant TT, Tashman S, Sumner DR, Kamath RV, Lust G, Kimura JH, Cs-Szabo G (2003) Spontaneous and experimental osteoarthritis in dog: similarities and differences in proteoglycan levels. J Orthop Res 21: 730-737.
• Long DL, Willey JS, Loeser RF (2013) Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments. Arthritis Rheum 65: 1561-1568.
• Lorenz H, Wenz W, Ivancic M, Steck E, Richter W (2005) Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading. Arthritis Res Ther 7: R156-R165.
• Luther JK, Cook CR, Cook JL (2009) Meniscal release in cruciate ligament intact stifles causes lameness and medial compartment cartilage pathology in dogs 12 weeks postoperatively. Vet Surg 38: 520-529.
• Matsukawa S, Tanimura M, Toyosaki-Maeda T, Noda A, Kobayashi M, Yamauchi A, Onoda J, Tsuji T, Takahashi T, Matsuo Y (2013) CIINE Reflects Collagenase-Specific CII Breakdown in Cartilage Explant and Whole Body of Canine. Biomark Insights 8: 77-83.
• Matyas JR, Atley L, Ionescu M, Eyre DR, Poole AR (2004) Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis. Arthritis Rheum 50: 543-552.
• Matyas JR, Huang D, Chung M, Adams ME (2002) Regional quantification of cartilage type II collagen and aggrecan messenger RNA in joints with early experimental osteoarthritis. Arthritis Rheum 46: 1536-1543.
• Misumi K, Vilim V, Carter SD, Ichihashi K, Oka T, Sakamoto H (2002) Concentrations of cartilage oligomeric matrix protein in dogs with naturally developing and experimentally induced arthropathy. Am J Vet Res 63: 598-603.
• Miyamoto K, Sugihara K, Abe Y, Nobori T, Tokita M, Komai T (2002) Novel plasma-separation dilayer gellan-gellan-sulfate adsorber for direct removal of extra domain A containing fibronectin from the blood of rheumatoid arthritis patients. Int J Biol Macromol 30: 197-204.
• Moreau M, Rialland P, Pelletier JP, Martel-Pelletier J, Lajeunesse D, Boileau C, Caron J, Frank D, Lussier B, Del Castillo J (2011) Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis Res Ther 13: R98.
• Musumeci G, Castrogiovanni P, Trovato F, Imbesi R, Giunta S, Szychlinska M, Loreto C, Castorina S, Mobasheri A (2015) Physical activity ameliorates cartilage degeneration in a rat model of aging: A study on lubricin expression. Scand J Med Sci Sports 25: e222-e230.
• Musumeci G, Trovato FM, Loreto C, Leonardi R, Szychlinska MA, Castorina S, Mobasheri A (2014) Lubricin expression in human osteoarthritic knee meniscus and synovial fluid: A morphological, immunohistochemical and biochemical study. Acta Histochem 116: 965-972.
• Nagase H, Kashiwagi M (2003) Aggrecanases and cartilage matrix degradation. Arthritis Res Ther 5: 94-103.
• Nganvongpanit K, Itthiarbha A, Ong-Chai S, Kongtawelert P (2008) Evaluation of serum chondroitin sulfate and hyaluronan: biomarkers for osteoarthritis in canine hip dysplasia. J Vet Sci 9: 317-325.
• Nia HT, Ortiz C, Grodzinsky A (2015) Aggrecan: approaches to study biophysical and biomechanical properties. Methods Mol Biol 1229: 221-237.
• Nusgens B (2010) Hyaluronic acid and extracellular matrix: a primitive molecule? Ann Dermatol Venereol 137: S3-8.
• Oliviero F, Sfriso P, Baldo G, Dayer J, Giunco S, Scanu A, Bernardi D, Ramonda R, Plebani M, Punzi L (2009) Apolipoprotein AI and cholesterol in synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Clin Exp Rheumatol 27: 79-83.
• Pelletier JP, Boileau C, Boily M, Brunet J, Mineau F, Geng C, Reboul P, Laufer S, Lajeunesse D, Martel-Pelletier J (2005) The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Res Ther 7: R1091-102.
• Pelletier JP, Boileau C, Brunet J, Boily M, Lajeunesse D, Reboul P, Laufer S, Martel-Pelletier J (2004) The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone 34: 527-538.
• Plickert H, Bondzio A, Einspanier R, Tichy A, Brunnberg L (2013) Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis. Res Vet Sci 94: 728-734.
• Pond M, Nuki G (1973) Experimentally-induced osteoarthritis in the dog. Ann Rheum Dis 32: 387-8.
• Poole AR, Ionescu M, Fitzcharles M, Billinghursta RC (2004) The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases. J Immunol Methods 294: 145-153.
• Pothacharoen P, Teekachunhatean S, Louthrenoo W, Yingsung W, Ong-Chai S, Hardingham T, Kongtawelert P (2006) Raised chondroitin sulfate epitopes and hyaluronan in serum from rheumatoid arthritis and osteoarthritis patients. Osteoarthritis Cartilage 14: 299-301.
• Prink A, Hayashi K, KIM SY, Kim J, Kapatkin A (2010) Evaluation of a collagenase generated osteoarthritis biomarker in the synovial fluid from elbow joints of dogs with medial coronoid disease and unaffected dogs. Vet Surg 39: 65-70.
• Przybysz M, Borysewicz K, Kątnik-Prastowska I (2009) Differences between the early and advanced stages of rheumatoid arthritis in the expression of EDA-containing fibronectin. Rheumatol Int 29: 1397-1401.
• Qi C, Changlin H (2006) Effects of moving training on histology and biomarkers levels of articular cartilage. J Surg Res 135: 352-363.
• Qi C, Changlin H (2007) Levels of biomarkers correlate with magnetic resonance imaging progression of knee cartilage degeneration: a study on canine. Knee Surg Sports Traumatol Arthrosc 15: 869-878.
• Rabillard M, Danger R, Doran I, Niebauer G, Brouard S, Gauthier O (2012) Matrix metalloproteinase activity in stifle synovial fluid of cranial cruciate ligament deficient dogs and effect of postoperative doxycycline treatment. Vet J 193: 271-273.
• Reesink HL, Watts AE, Mohammed HO, Jay GD, Nixon AJ (2016) Lubricin/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis. Osteoarthritis Cartilage 25: 128-137.
• Rifai N, Gillette MA, Carr SA (2006) Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 24: 971-983.
• Sasaki E, Tsuda E, Yamamoto Y, Iwasaki K, Inoue R, Takahashi I, Sawada K, Fujita H, Umeda T, Nakaji S (2013) Serum hyaluronan levels increase with the total number of osteoarthritic joints and are strongly associated with the presence of knee and finger osteoarthritis. Int Orthop 37: 925-930.
• Scanzello CR, Markova DZ, Chee A, Xiu Y, Adams SL, Anderson G, Zgonis M, Qin L, An HS, Zhang Y (2015) Fibronectin splice variation in human knee cartilage, meniscus and synovial membrane: observations in osteoarthritic knee. J Orthop Res 33: 556-562.
• Schoenherr WD, MacLeay JM, Yamka RM (2010) Evaluation of body composition and cartilage biomarkers in large-breed dogs fed two foods designed for growth. Am J Vet Res 71: 934-939.
• Settle S, Vickery L, Nemirovskiy O, Vidmar T, Bendele A, Messing D, Ruminski P, Schnute M, Sunyer T (2010) Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes. Arthritis Rheum 62: 3006-3015.
• Šimáneka V, Křenb V, Ulrichováa J, Galloc J (2005) The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: are these saccharides drugs or nutraceuticals? Biomed Pap 149: 51-56.
• Skoumal M, Haberhauer G, Feyertag J, Kittl E, Bauer K, Dunky A (2006) Serum levels of cartilage oligomeric matrix protein (COMP): a rapid decrease in patients with active rheumatoid arthritis undergoing intravenous steroid treatment. Rheumatol Int 26: 1001-1004.
• Spector T, Woodward L, Hall G, Hammond A, Williams A, Butler M, James I, Hart D, Thompson P, Scot D (1992) Keratan sulphate in rheumatoid arthritis, osteoarthritis, and inflammatory diseases. Ann Rheum Dis 51: 1134-1137.
• Steffey MA, Miura N, Todhunter RJ, Nykamp SG, Freeman KP, Scarpino V, Vernier-Singer MA, Erb HN, MacLeod JN, Lust G (2004) The potential and limitations of cartilage- specific (V+ C)-fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid. Osteoarthritis Cartilage 12: 818-825.
• Stoffels JM, Zhao C, Baron W (2013) Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build. Cell Mol Life Sci 70: 4243-4253.
• Stone AV, Loeser RF, Vanderman K, Long D, Clark SC, Ferguson CM (2014) Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis. Osteoarthritis Cartilage 22: 264-274.
• Struglics A, Larsson S, Pratta MA, Kumar S, Lark M, Lohmander L (2006) Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase-and matrix metalloproteinase- generated aggrecan fragments. Osteoarthritis Cartilage 14: 101-113.
• Szychlinska M, Leonardi R, Al-Qahtani M, Mobasheri A, Musumeci G (2016) Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches. Ann Phys Rehabil Med 59: 149-56
• Taguchi M, Sun YL, Zhao C, Zobitz ME, Cha CJ, Jay GD, An KN, Amadio PC (2009) Lubricin surface modification improves tendon gliding after tendon repair in a canine model in vitro. J Orthop Res 27: 257-263.
• Tesche F, Miosge N (2004) Perlecan in late stages of osteoarthritis of the human knee joint. Osteoarthritis Cartilage 12: 852-862.
• Valiyaveettil M, Mort JS, McDevitt CA (2005) The concentration, gene expression, and spatial distribution of aggrecan in canine articular cartilage, meniscus, and anterior and posterior cruciate ligaments: a new molecular distinction between hyaline cartilage and fibrocartilage in the knee joint. Connect. Tissue Res 46: 83-91.
• Venable RO, Stoker AM, Cook CR, Cockrell MK, Cook JL (2008) Examination of synovial fluid hyaluronan quantity and quality in stifle joints of dogs with osteoarthritis. Am J Vet Res 69: 1569-1573.
• Vilar JM, Rubio M, Spinella G, Cuervo B, Sopena J, Cugat R, Garcia-Balletbó M, Dominguez JM, Granados M, Tvarijonaviciute A (2016) Serum Collagen Type II Cleavage Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis. PLoS One 11: e0149472.
• Wakitani S, Nawata M, Kawaguchi A, Okabe T, Takaoka K, Tsuchiya T, Nakaoka R, Masuda H, Miyazaki K (2007) Serum keratan sulfate is a promising marker of early articular cartilage breakdown. Rheumatology (Oxford) 46: 1652-1656.
• Wei L, Fleming BC, Sun X, Teeple E, Wu W, Jay GD, Elsaid KA, Luo J, Machan JT, Chen Q (2010) Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model. J Orthop Res 28: 900-906.
• Westwood R, Scott RC, Somers RL, Coulson M, Maciewicz RA (2009) Characterization of fibrodysplasia in the dog following inhibition of metalloproteinases. Toxicol Pathol 37: 860-872.
• Wilke VL, Robinson DA, Evans RB, Rothschild MF, Conzemius MG (2005) Estimate of the annual economic impact of treatment of cranial cruciate ligament injury in dogs in the United States. J Am Vet Med Assoc 227: 1604-1607.
• Young AA, McLennan S, Smith MM, Smith SM, Cake MA, Read RA, Melrose J, Sonnabend DH, Flannery CR, Little CB (2006) Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Res Ther 8: R41.
• Yun S, Ku SK, Kwon YS (2016) Adipose-derived mesenchymal stem cells and platelet-rich plasma synergistically ameliorate the surgical-induced osteoarthritis in Beagle dogs. J Orthop Surg Res 11: 9.
• Zack MD, Arner EC, Anglin CP, Alston JT, Malfait AM, Tortorella MD (2006) Identification of fibronectin neoepitopes present in human osteoarthritic cartilage. Arthritis Rheum 54: 2912-2922.
• Zack MD, Malfait AM, Skepner AP, Yates MP, Griggs D.W, Hall T, Hills RL, Alston JT, Nemirovskiy OV, Radabaugh MR (2009) ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala271. Arthritis Rheum 60: 2704-2713.
• Zhao C, Wei Z, Reisdorf RL, Thoreson AR, Jay GD, Moran SL, An KN, Amadio PC (2014) The Effects of Biological Lubricating Molecules on Flexor Tendon Reconstruction in a Canine Allograft Model In Vivo. Plast Reconstr Surg 133: 628e-637e.

Identyfikatory

DOI

10.1515/pjvs-2017-0024