Ultrasonic vocalization (USV) in calbindin D-28k mutant mice

• Autorzy: Grabowska M. , Slugocka A. , Barski J. J.
• Języki publikacji: EN

Abstrakty

EN

Mice similarly to some other rodent species communicate with specialized sounds in the ultrasonic range called ultrasonic vocalizations (USV). Evaluation of this behavioral activity enables estimation of the social interactions in animal models of diseases involving psychiatric manifestations related to the social environment like autistic spectrum disorders (ASD). Because of the growing evidence for involvement of cerebellum in ethiology of ASD, we decided to change physiological properties of Purkinje cells and look for signs of alterations in USV activity of newborns. In our experiments we switched off expression of the major protein calcium buffer (calbindin D-28k) in these neurons by means of the Cre/loxP technology. It is known from previous reports (1), that the lack of calbindin D-28k in cerebellar cortex results in motor coordination deficits due to disturbed processing of calcium signaling in Purkinje cells. Because coordination of the vocal apparatus depends on the cerebellar input we were curious if altered Purkinje cells function results in altered USV calling.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.46

Twórcy

autor

Grabowska M.

• Center for Experimental Medicine, Medical University of Silesia, Katowice, Poland

autor

Slugocka A.

• Center for Experimental Medicine, Medical University of Silesia, Katowice, Poland

autor

Barski J. J.

• Center for Experimental Medicine, Medical University of Silesia, Katowice, Poland
• Department of Physiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland