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1989 | 40 | 4 |

Tytuł artykułu

Inhibition of ethanol-induced changes in rats by Padma 28

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EN

Abstrakty

EN
Wójcicki, J. Samochowiec, L. and Kadłubowska D.: Inhibition of ethanol- -induced changes in rats by Padma 28. Acta physiol, pol., 1989, 40 (4): 387-392. In male Wistar rats the protective effect of Padma 28 against changes induced by prolonged treatment with ethyl alcohol was investigated. Exposure of the animals to prolonged ethyl alcohol consumption caused a significant liner ease in AspAT (by 32%) AlAT (by 50%) and alkaline phosphatase (by 372%) activities as well as ian increase in the levels of bilirubin (by 98%) and lipids in the blood serum and lipids in the liver homogenate. Padma 28 administration was found to exert a protective action against these changes: a significant reduction of blood total lipid, triacylglycerol, total cholesterol and bilirubin concentrations as well as in the activity of the liver enzymes was observed.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

40

Numer

4

Opis fizyczny

p.387-392,ref.

Twórcy

autor
  • Institute of Pharmacology and Toxicology, School of Medicine, Szczecin, Poland
  • Institute of Pharmacology and Toxicology, School of Medicine, Szczecin, Poland
  • Institute of Pharmacology and Toxicology, School of Medicine, Szczecin, Poland

Bibliografia

  • 1. Badmajew, P. Jr., Badmajew, V. Jr., Park, L. (1982) Healing Herbs, Berkeley, Lotus Press.
  • 2. Barboriak, J. J. (1974) Hyperlipidemia in alcoholics. Quart. J. Stud. Alc. 35. 15-19.
  • 3. Błaszczyszyn, M. (1970) Precise and simple determination of cholesterol in serum (in Polish). Wiad. Lek. 16. 1413-1417.
  • 4. Brzosko, W. J., Badmajew, W., Plachcińska, J., Beraud, M., Golonko, L., Dąbrowa, A., Krzysztofik, R., Matacz, D. (1983) Laboratory and clinical studies on Padma 28 (in Polish). Immun. Pol. 8. 216.
  • 5. Brzosko, W. J., Badmajew, V. Jr., Plachcińska, J., Loch, T., Krzysztofik, R., Matacz, D., Beroud, M., Golonko, L. (1983) Padma 28, a new drug for patients with HBsAG positive or negative chronic aggressive hepatitis. Hepatology, Rapid Liter Rev. 13. 22.
  • 6. Das, M. Р., Sothy, S. Р. (1971) Studies on flavonoid metabolism. Biochem. J. 125. 417-423.
  • 7. Eggstein, M., Kreutz, F. H. (1966) Eine neue Bestimmung der Neutralfette in Blutserum und Gewebe. Klin. Wschr. 44. 262-267.
  • 8. Krawczyński, J. (1967) Laboratory Diagnostic Methods (in Polish). PZWL, Warszawa.
  • 9. Krygier, В. (1963) Fast and precise methods of determination of glucose level in the blood and cerebrospinal fluid by means of o-toluidine (in Polish). Wiad. Lek. 16. 1133-1136.
  • 10. Lieber, C. S. (1973) Liver adaptation and injury in alcoholism. N. Engl. J. Med. 288. 356-362.
  • 11. Lieber, C. S., Schmid, R. (1961) The effect of ethanol on fatty acid metabolism: stimulation of hepatic fatty acid synthesis in vitro. J. Clin. Invest. 40. 394-399.
  • 12. Pimstone, N. R., French, S. W. (1984) Alcoholic liver disease. Med. Clin. North. Amer. 68. 39-56.
  • 13. Reitman, S., Frankel, S. (1957) A colorimetric method for determination of serum glutamic exalacetic and glutamic pyruvic transaminases. Amer. J. Clin. Path. 28. 56-62.
  • 14. Samochowies, L. (1983) Theoretical, chemical and pharmacodynamical examinations of Padma 28. First International Convention on Tibetan Medicine. Venice, April 1983.
  • 15. Samochowiec, L., Janiec, W., Wójcicki, J. (1986) Influence of Padma 28 on the oxidation of palmitic acid-l-¹⁴C to ¹⁴CO₂. Herba Polon. 32. 183-4186.
  • 16. Samochowiec, L., Wójcicki, J. (1987) Effect of Padma 28 on lipid endoperoxides formation. Herba Polon. 33. 219-222.
  • 17. Thaler, H. (1977) Alcohol consumption and diseases of the liver. Nutr. Metab. 21. 186-193.
  • 18. Zöllner, N., Kirsch, K. M. (1962) Uber die quantitative Bestimmung von Lipoiden mittels der vielen naturlichen Lipoiden (allen bekannten Plasmolipoiden), gemain- samen Sulphosphovanillin Reaction. Z. Ges. Exp. Med. 135. 545-561.

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Bibliografia

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