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2010 | 70 | 3 |
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Lithium enhances cortical mRNA expression in ovariectomized C57BL/6J mice

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Języki publikacji
The hippocampus and cortex of the mammalian brain are regions involved in learning and long-term memory. Estrogen and lithium affect similar learning and memory molecular processes. We hypothesized that in ovariectomized mice lithium treatment will enhance genetic factors in the brain that are involved in neuroprotection, learning and memory. Our study used bilaterally ovariectomized (bOVX) C57BL/6J mice treated for one month with 14.2 mM LiCl in their drinking water. Results indicate that LiCl-treated bOVX mice show enhanced cortical increases in mRNA expression of ER-α, NR1, Bcl-2, BDNF, and CaMkII-α; hippocampal mRNA showed no changes. Our results indicate that in bOVX C57BL/6J mice, lithium enhances the expression of specific cortical genes coded for proteins involved in learning, memory and neuroprotection.
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  • Department of Biological Sciences, Florida International University, Florida, USA
  • Department of Biological Sciences, Florida International University, Florida, USA
  • Department of Biological Sciences, Florida International University, Florida, USA
  • Department of Biological Sciences, Florida International University, Florida, USA
  • Angelucci F, Aloe L, Jimenez-Vasquez P, Mathe AA (2003) Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression. Int J Neuropsychopharmacol 6: 225-231.
  • Blanquet PR, Mariani J, Derer P (2003) A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic amp-responsive transcription factor in the rat hippocampus. Neuroscience 118: 477-490.
  • Bodo C, Rissman EF (2006) New roles for estrogen receptor beta in behavior and neuroendocrinology. Front Neuroendocrinol 27: 217-232.
  • Celano E, Tiraboschi E, Consogno E, D'Urso G, Mbakop MP, Gennarelli M, de Bartolomeis A, Racagni G, Popoli M (2003) Selective regulation of presynaptic calcium/ calmodulin-dependent protein kinase II by psychotropic drugs. Biol Psychiatry 53: 442-449.
  • Chuang DM (2005) The antiapoptotic actions of mood sta­bilizers. Ann NY Acad Sci 1053: 195-204.
  • Clement-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssiere Ba, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G (2005) Lrp5-independent activation of Wnt signaling by lithium chloride increases bone for­mation and bone mass in mice. Proc Natl Acad Sci USA 102: 17406-17411.
  • Fugger HN, Foster TC, Gustafsson JA, Rissman EF (2000) Novel effects of estradiol and estrogen receptor a and p on cognitive function. Brain Res 883: 258-264.
  • Galeeva A, Tuohimaa P (2001) Analysis of mouse plus-maze behavior modulated by ovarian steroids. Behav Brain Res 119: 41-47.
  • Garcia-Segura LM, Azcoitia I, DonCarlos LL (2001) Neuroprotection by estradiol. Prog Neurobiol 63: 29-60.
  • Grimes CA, Jope RS (2001) CREB DNA binding activity is inhibited by glycogen synthase kinase-3p and facilitated by lithium. J Neurochem 78: 1219-1232.
  • Gunin AG, Emelianov VU, Mironkin IU, Morozov MP, Tolmachev AS (2004) Lithium treatment enhances estradiol-induced proliferation and hyperplasia formation in the uterus of mice. Eur J Obstet Gynecol Reprod Biol 114: 83-91.
  • Harwood AJ (2004) Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited. Mol Psychiatry 10: 117-126.
  • Henderson VW (2009) Menopause, cognitive ageing and dementia: practice implications. Menopause International 15: 41-44.
  • Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A (2001) Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neu­rons. J Neurosci Res 64: 466-475.
  • Hongisto V, Smeds N, Brecht S, Herdegen T, Courtney MJ, Coffey ET (2003) Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Mol Cell Biol 23: 6027-6036.
  • Horner KC (2009) The effect of sex hormones on bone metabolism of the otic capsule - an overview. Hear Res 252: 56-60.
  • Jakobsen SN, Wiborg O (1998) Selective effects of long- term lithium and carbamazepine administration on G-protein subunit expression in rat brain. Brain Res 780: 46-55.
  • Jope RS (1999) A bimodal model of the mechanism of action of lithium. Mol Psychiatry 4: 21-25.
  • Jope RS (2003) Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci 24: 441-443.
  • Lenox RH, Watson DG (1994) Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness. Clin Chem 40: 309-314.
  • Leranth C, Shanabrough M, Redmond Jr. DE (2002) Gonadal hormones are responsible for maintaining the integrity of spine synapses in the CA1 hippocampal sub- field of female nonhuman primates. The Journal of Comparative Neurology 447: 34-42.
  • Lerer B, Macciardi F (2002) Pharmacogenetics of antide­pressant and mood-stabilizing drugs: a review of candi­date-gene studies and future research directions. Int J Neuropsychopharmacol 5: 255-275.
  • Manji HK, Moore GJ, Chen G (2001) Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers. Br J Psychiatry 178: s107- 119.
  • Masuda H, Tsujimura A, Yoshioka M, Arai Y, Kuboki Y, Mukai T, Nakamura T, Tsuji H, Nakagawa M, Hashimoto- Gotoh T (1997) Bone mass loss due to estrogen defi­ciency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1. Biochem Biophys Res Commun 238: 528-533.
  • McEwen BS (2001) Genome and hormones: gender differ­ences in physiology: invited review. Estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol. 91: 2785-2801.
  • Murray C, Stone G (1989) Delayed response of the mouse uterus to progesterone and oestradiol. Reprod Fertil Dev 1: 107-115.
  • Natale V, Albertazzi P, Missiroli N, Pedrini D, Salgarello M (2004) Effects of raloxifene on mood, sleep, libido and cognitive function in postmenopausal healthy women: a pilot study. Maturitas 48: 59-63.
  • Newcomer LM, Newcomb PA, Potter JD, Yasui Y, Trentham- Dietz A, Storer BE, Longnecker MP, Baron JA, Daling JR (2003) Postmenopausal hormone therapy and risk of breast cancer by histologic type United States. Cancer Causes Control 14: 225-233.
  • Ozaki N, Chuang D-M (1997) Lithium Increases Transcription Factor Binding to AP-1 and Cyclic AMP-Responsive Element in Cultured Neurons and Rat Brain. J Neurochem 69: 2336-2344.
  • Palmer J, Trotter T, Joy A, Carlson L (2008) Cognitive effects of tamoxifen in pre-menopausal women with breast cancer compared to healthy controls. J Cancer Surviv 2: 275-282.
  • Rushlow WJ, Seah C, Sutton LP, Bjelica A, Rajakumar N (2009) Antipsychotics affect multiple calcium calmodulin dependent proteins. Neuroscience 161: 877-886.
  • Sadeghipour-Roudsari HR, Farahani M, Shokrgozar A, Farsam H, Dehpour AR (1998) Decrease in erythrocyte: plasma lithium ratio by concurrent administration of psy­chotropic drugs and lithium in mice. Gen Pharmacol 31: 63-66.
  • Sherwin BB (2005) Estrogen and memory in women: how can we reconcile the findings? Horm Behav 47: 371.
  • Sierra A (2004) Neurosteroids: the StAR protein in the brain. J Neuroendocrinol 16: 787-793.
  • Simpkins J, Green P, Gridley K, Singh M, de Fiebre N, Rajakumar G (1997) Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. Am J Med 103: 19S-25S.
  • Solum DT, Handa RJ (2002) Estrogen regulates the develop­ment of brain-derived neurotrophic factor mRNA and pro­tein in the rat hippocampus. J Neurosci 22: 2650-2659.
  • Suda S, Segi-Nishida E, Newton SS, Duman RS (2008) A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation. Biol Psychiatry 64: 311-319.
  • Wheeler DG, Cooper E (2004) Weak synaptic activity induces ongoing signaling to the nucleus that is enhanced by BDNF and suppressed by low-levels of nicotine. Mol Cell Neurosci 26: 50-62.
  • Wise PM (2002) Estrogens and neuroprotection. Trends Endocrinol Metab 13: 229-230.
  • Zamani A, Omrani GR, Nasab MM (2009) Lithium's effect on bone mineral density. Bone 44: 331-334.
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