Cytokines in canine inflammatory bowel disease

• Autorzy: Kolodziejska-Sawerska A. , Rychlik A. , Depta A. , Wdowiak M. , Nowicki M. , Kander M.
• Języki publikacji: EN

Abstrakty

EN

Canine inflammatory bowel disease is a group of chronic enteropathies characterized by persistent or recurring gastric symptoms with an unknown etiology which are related to histopathological changes in the mucosa of the small and large bowel in the form of cellular infiltration in the mucosal lamina propria. Recent years have witnessed a growing number of investigations into the role of the immune system and, in particular, cytokines in the development of IBD. In this article, the expression of pro-inflammatory (IL-1, IL-2, IL-5, IL-6, IL-12, IL-18, IFN-γ, TNF-α) and anti-inflammatory cytokines (IL-4, IL-10) was compared in canine patients with IBD based on clinical presentation, breed, lamina propria cell infiltrate and histopathological grade. Only selected studies confirmed higher mRNA expression levels of cytokines IL-2, IL-4, IL-5, IL-12p40, IFN-γ, TNF-α and TGF-β in dogs with IBD in comparison with healthy subjects. GSD were strongly represented in most study populations. Dogs with LPE were characterized by elevated levels of IL-1α, IL-1β, IL-2, IL-5, IL-6, IL-12, TNF-α, TGF-β. The present studies of canine patients with LPC revealed the mRNA expression of cytokines IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p35, IL-12p40, IFN-γ, TNF-α, TGF-β. In the reviewed studies, the progression of IBD was not accompanied by changes in the mRNA expression of IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-18, TNF-α, IFN-γ or TGF-β.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2013
• Tom: 16
• Numer: 1
• Opis fizyczny: p.165-171,ref.

Twórcy

autor

Kolodziejska-Sawerska A.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland

autor

Rychlik A.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland

autor

Depta A.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland

autor

Wdowiak M.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland

autor

Nowicki M.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland

autor

Kander M.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland

Bibliografia

• Allenspach K, House A, Smith K, McNeill FM, Hendricks A, Elson-Riggins J, Riddle A, Steiner JM, Werling D, Garden OA, Catchpole B, Suchodolski JS (2010) Evaluation of mucosal bacteria and histopathology, clinical disease activity and expression of Toll-like receptors in German shepherd dogs with chronic enteropathies. Vet Microbiol 146: 326-335.
• Allenspach K, Wieland B, Grone A, Gaschen F (2007) Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med 21: 700-708.
• Batt RM, Needham JR, Carter MW (1983) Bacterial overgrowth associated with a naturally occurring enteropathy in the German shepherd dog. Res Vet Sci 35: 42-46.
• Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 98: 1010-1020.
• Bhatia V, Tandon RK (2005) Stress and the gastrointestinal tract. J Gastroenterol Hepatol 20: 332-339.
• Chojnacki J, Wichan P (2004) Pathogenetic background and principles of the conservative treatment of inflammatory bowel diseases. Pediatria Współczesna 6: 441-447.
• Chrząstowska M (2009) The evaluation of the efficacy of potentially probiotic bacteria Enterococcus in the treatment of inflammatory bowel disease. Doctoral thesis. University of Warmia and Mazury, Faculty of Veterinary Medicine, Department of Clinical Diagnostics, Olsztyn, Poland.
• Craven M, Simpson JW, Ridyard AE, Chandler ML (2004) Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). J Small Anim Pract 45: 336-342.
• Day MJ, Bilzer T, Mansell J, Wilcock B, Hall EJ, Jergens A, Minami T, Willard M, Washabau R (2008) Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standarization Group. J Comp Pathol 138: s1-43.
• De Majo M, Pugliese M, Galia S, Mazzullo G, La Camera E, Fera MT (2008) Cytokine mRNA quantification in gastro-intestinal biopsies of dogs with idiopathic chronic enteropathies by real-time RT-PCR: preliminary results. Vet Res Commun 32: s275-277.
• Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, Yang Z, Exley M, Kitani A, Blumberg RS, Mannon P, Strober W (2004) Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 113: 1490-1497.
• Fuss IJ, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, Fiocchi C, Strober W (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157: 1261-1270.
• German AJ, Hall EJ, Day MJ (2003) Chronic intestinal inflammation and intestinal disease in dogs. J Vet Intern Med 17: 8-20.
• German AJ, Hall EJ, Day MJ (2001) Immune cell populations within the duodenal mucosa of dogs with enteropathies. J Vet Intern Med 15: 14-25.
• German AJ, Helps CR, Hall EJ, Day MJ (2000) Cytokine mRNA expression in mucosal biopsies from German shepherd dogs with small intestinal enteropathies. Dig Dis Sci 45: 7-17.
• Hall EJ (2007) Mucosal immunology – why it’s important; immune-mediated intestinal disease. Proceedings of the 32nd Annual WSAVA Congress. Sydney, 19-23. 08. 2007. http://www.vin.com/proceedings/Proceedings.plx?&CID =WSAVA2007&PID=pr18137&O=Generic
• Holtta V, Klemetti P, Sipponen T, Westerholm-Ormio M, Kociubinski G, Salo H, Rasanen L, Kolho KL, Farkkila M, Savilahti E, Vaarala O (2008) IL-23/IL-17 immunity as a hallmark of Crohn’s disease. Inflamm Bowel Dis 14: 1175- 1184.
• Jergens AE, Schreiner CA, Frank DE, Niyo Y, Ahrens FE, Eckersall PD, Benson TJ, Evans R (2003) A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med 17: 291-297.
• Jergens AE, Simpson KW (2012) Inflammatory bowel disease in veterinary medicine. Front Biosci (Elite Ed) 4: 1404-1419.
• Jergens AE, Sonea IM, O’Connor AM, Kauffman LK, Grozdanic SD, Ackermann MR, Evans RB (2009) Intestinal cytokine mRNA expression in canine inflammatory bowel disease: a meta-analysis with critical appraisal. Comp Med 59: 153-162.
• Jump RL, Levine AD (2004) Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease. Inflamm Bowel Dis 10: 462-478.
• Littler RM, Batt RM, Lloyd DH (2006) Total and relative deficiency of gut mucosal IgA in German shepherd dogs demonstrated by faecal analysis. Vet Rec 158: 334-341.
• Malewska K (2010) The effectiveness of natural and synthetic immunomodulators in the treatment of inflammatory bowel disease (IBD) in dogs. PhD Thesis. University of Warmia and Mazury, Faculty of Veterinary Medicine, Department of Clinical Diagnostics, Olsztyn, Poland.
• McCann TM, Ridyard AE, Else RW, Simpson JW (2007) Evaluation of disease activity markers in dogs with idiopathic inflammatory bowel disease. J Small Anim Pract 48: 620-625.
• Naito Y, Takagi T, Uchiyama K, Kuroda M, Kokura S, Ichikawa H, Yanagisawa R, Inoue K, Takano H, Satoh M, Yoshida N, Okanoue T, Yoshikawa T (2004) Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. Int J Mol Med 14: 191- 196.
• Owczarek D, Cibor D, Szczepanek M, Mach T (2009) Biological therapy of inflammatory bowel disease. Polskie Archiwum Medycyny Wewnętrznej 119: 84-89.
• Peters IR, Helps CR, Calvert EL, Hall EJ, Day MJ (2005) Cytokine mRNA quantification in duodenal mucosa from dogs with chronic enteropathies by real-time reverse transcriptase polymerase chain reaction. J Vet Intern Med 19: 644-653.
• Polińska B, Matowicka-Karna J, Kemona H (2009) The cytokines in inflammatory bowel disease. Postępy Higieny Medycyny Doświadczalnej 63: 389-394.
• Powrie F, Leach MW, Mauze S, Caddle LB, Coffman RL (1993) Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 5: 1461-1471.
• Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL (1994) Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1: 553-562.
• Ridyard AE, Nuttall TJ, Else RW, Simpson JW, Miller HR (2002) Evaluation of Th1, Th2 and immunosuppressive cytokine mRNA expression within the colonic mucosa of dogs with idiopathic lymphocytic-plasmacytic colitis. Vet Immunol Immunopathol 86: 205-214.
• Rogler G, Andus T (1998) Cytokines in inflammatory bowel disease. World J Surg 22: 382-389.
• Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto--Furusho JK (2008) Role of cytokines in inflammatory bowel disease. World J Gastroenterol 14: 4280-4288.
• Sandborn WJ, Targan SR (2002) Biologic therapy of inflammatory bowel disease. Gastroenterology 122: 1592-1608.
• Sartor RB (1995) Insights into the pathogenesis of inflammatory bowel diseases provided by new rodent models of spontaneous colitis. Inflamm Bowel Dis 1: 64-75.
• Sartor RB (2006) Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3: 390-407.
• Sauter SN, Allenspach K, Blum JW (2007) Cytokine mRNA abundance in intestinal biopsies from dogs with chronic diarrhea. Vet Med 52: 353-364.
• Shanahan F (2002) Crohn’s disease. Lancet 359: 62-69. Simpson KW, Jergens AE (2011) Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet Clin North Am Small Anim Pract 41: 381-398.
• Xavier RJ, Podolsky DK (2007) Unraveling the pathogenesis of inflammatory bowel disease. Nature 448: 427-434.
• Xenoulis PG, Palculict B, Allenspach K, Steiner JM, Van House AM, Suchodolski JS (2008) Molecular-phylogenetic characterization of microbial communities imbalances in the small intestine of dogs with inflammatory bowel disease. FEMS Microbiol Ecol 66: 579-589.
• Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116: 1310-1316.

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