Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer - the DNA microarray assay

• Autorzy: Stojcev Z. , Banasiewicz T. , Kaszuba M. , Sikorski A. , Szczepkowski M. , Bobkiewicz A. , Paszkowski J. , Krokowicz L. , Biczysko M. , Szmeja J. , Jurkowska M. , Majewski P. , Mackiewicz A. , Lamperska K. , Drews M. , Wojciechowicz J.
• Języki publikacji: EN

Abstrakty

EN

 Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.

Słowa kluczowe

EN

development; diagnostics; genetic screening; hereditary colorectal cancer; DNA microarray; colon cancer; high-risk group; patient

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 2
• Opis fizyczny: p.195-198,ref.

Twórcy

autor

Stojcev Z.

• Regional Specialistic Hospital, Slupsk, Department of General, Vascular and Oncologic, Surgery, Slupsk, Poland
• Department of Oncologic Surgery, Gdansk Medical University, Gdansk, Poland

autor

Banasiewicz T.

• Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland

autor

Kaszuba M.

• Medical Genetic Laboratory, DNA Research Center Ltd., Poznan, Poland

autor

Sikorski A.

• Medical Genetic Laboratory, DNA Research Center Ltd., Poznan, Poland

autor

Szczepkowski M.

• Department of Rehabilitation, Jozef Pilsudski University of Physical Education in Warsaw, Warsaw, Poland
• Clinical Department of General and Colorectal Surgery, Bielanski Hospital in Warsaw, Warsaw, Poland

autor

Bobkiewicz A.

• Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland

autor

Paszkowski J.

• Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland

autor

Krokowicz L.

• Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland

autor

Biczysko M.

• Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland

autor

Szmeja J.

• Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland

autor

Jurkowska M.

• Medical Genetic Laboratory, DNA Research Center Ltd., Poznan
• Institute of Rheumatology, Department of Biochemistry and Molecular Biology, Warsaw, Poland

autor

Majewski P.

• Department of Clinical Pathomorphology, Poznan University of Medical Sciences, Poznan, Poland

autor

Mackiewicz A.

• Department of Cancer Immunology, Poznan University of Medical Sciences, Greater Poland Cancer Center, Poznan, Poland

autor

Lamperska K.

• Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland

autor

Drews M.

• Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland;

autor

Wojciechowicz J.

• Medical Genetic Laboratory, DNA Research Center Ltd., Poznan, Poland

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