Utility of urinary markers in the assessment of renal dysfunction in dogs with chronic kidney disease

• Autorzy: Winiarczyk D.
• Języki publikacji: EN

Abstrakty

EN

Chronic kidney disease is a common and clinically significant disease. This complication leads to a decrease of the glomerular filtration rate and in consequence causes azotaemia and uraemia. The objective of this study was to assess the localization and extent of renal damage in dogs with stage-3 chronic kidney disease using a urinary marker for glomerular dysfunction, proximal tubular dysfunction and distal tubular dysfunction (uIgG, uRBP and uTHP, respectively). The examination was performed in twelve dogs affected in stage-3 chronic kidney disease and ten clinically healthy dogs (female and male of comparable age). The levels of urinary biomarkers were measured by commercially available ELISA-tests. In the infected animals a significant renal excretion of HMW protein uIgG and LMW protein uRBP was observed, indicating a dysfunction of the glomerular and tubular regions of the kidneys. Lower levels of uTHP in dogs with CKD was noticed, which may suggest impaired distal tubular regions of the kidneys.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2020
• Tom: 76
• Numer: 09
• Opis fizyczny: p.525-528,ref.

Twórcy

autor

Winiarczyk D.

• Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland

Bibliografia

• 1. Bachmann S., Dawnay A. B, Bouby N., Bankir L.: Tamm-Horsfall protein excretion during chronic alteration in urinary concentration and protein intake in the rat. Ren. Physiol. Biochem. 1991, 14, 236-245.
• 2. Bang L. E., Holm J., Svendsen T.: Retinol-Binding Protein and Transferrin in urine. New markers of renal function in essential hypertension and white coat hypertension? Am. J. Hypertens. 1996, 9, 1024-1028.
• 3. Bernard A. M., Vyskocil A. A., Mahieu P.: Assessment of urinary retinol-binding protein as an index of proximal tubular injury. Clin. Chem. 1987, 33, 775-779.
• 4. Burbure C. de, Buchet J. P., Bernard A., Leroyer A., Nisse C., Haguenoer J. M., et al.: Biomarkers of renal effects in children and adults with low environmental exposure to heavy metals. J. Toxicol. Environ. Health. 2003, 66, 783-798.
• 5. Cairns H. S., Dawnay A., Woolfson R. G., Unwin R. J.: Evaluation of therapy for cast nephropathy: failure of colchicine to after urinary Tamm-Horsfall glycoprotein excretion in normal subjects. Exp. Nephrol. 1994, 2, 257-258.
• 6. Camara N. O., Silva M. S., Nishida S., Pereira A. B., Pacheco-Silva A.: Proximal tubular dysfunction is associated with chronic allograft nephropathy and decreased long-term renalgraft survival. Transplantation 2004, 78, 269-275.
• 7. Cowgill L. D., Langston C.: Acute kidney insufficiency, [in:] Bartges J., Polzin D. J. (eds.): Nephrology and Urology of Small Animals. Wiley-Blackwell 2011, p. 472-523.
• 8. D’Amico G., Bazzi C.: Pathophysiology of proteinuria. Kidney Int. 2003, 63, 809-825.
• 9. Dawnay A. B., Thornley C., Cattle W. R.: An improved radioimmunoassay for urinary Tamm-Horsfall glycoprotein. Investigation and resolution of factors affecting its quantification. Biochem. J. 1982, 206, 461-465.
• 10. Finco D. R.: Kidey function, [in:] Kaneko J. J., Harvey J. W., Bruss M. L. (eds.): Clinical Biochemistry of Domestic Animals. San Diego, CA 1995, 441-484.
• 11. Forterre S., Raila J., Schweigert F. J.: Protein profiling of urine from dogs with disease using Protein Chip analysis. J. Vet. Invest. 2004, 16, 271-277.
• 12. Gekle M.: Renal tubule albumin transport Annu. Rev. Physiol. 2005, 67, 573-594.
• 13. Gruer A. M., Neuberger A.: The development of a radioimmunoassay for the measurement of urinary Tamm-Horsfall glycoprotein in the presence of sodium dodecyl sulphate. Clin. Sci. 1973, 44, 163-179.
• 14. Haraldsson B., Nyström J., Deen M. W.: Properties of the Glomerular Barrier and Mechanisms of Proteinuria. Physiol. Rev. 2003, 88, 451-487.
• 15. Horton J. K., Davies M., Woodhead J. S., Weeks I.: A new and rapid immunochemiluminometric assay for the measuremnt of Tamm-Horsfall glycoprotein. Clin. Chim. Acta. 1998, 174, 225-237.
• 16. Liu D. X. J., Meyer E., Broeckx B. J. G., Daminet S., Delanghe J. R., Stock E., et al.: Variability of Serum Concentrations of Cystatin C and Urinary RetinolBinding Protein, Neutrophil Gelatinase-Associated Lipocalin, Immunoglobulin G, and C-reactive Protein in Dogs. J. Vet. Intern. Med. 2018, 32, 1659-1664.
• 17. Kanals J. J., Hopfer U.: Effect of TGF-beta 1 and TNF-alpha on the plasminogen system of rat proximal tubular epithelial cells. J. Am. Soc. Nephrol. 1997, 8, 184-192.
• 18. Kirsztajn G. M., Nishida S. K., Silva M. S., Azjen H., Pereira A. B.: Urinary retinol binding protein as a prognostic marker in the treatment of nephrotic syndrome. Nephron 2000, 86, 109-114.
• 19. Kovarikova S.: Urinary biomarkers of renal function in dogs. Veterinarni Medicina 2015, 60, 589-602.
• 20. Lynn K. L., Marshall R. D.: Excretion of Tamm-Horsfall glycoprotein in renal disease. Clin. Nephrol. 1984, 22, 253-257.
• 21. Maack T., Park C. H., Camargo M. J. F.: Renal filtration, transport, and metabolism of proteins, [in:] Seldin D. W., Giebisch G. (eds.): The kidney: physiology and pathophysiology. New York 1992, p. 3005-3038.
• 22. Maddens B. E. J., Daminet S., Demeyere K., Demon D., Smets P., Meyer E.: Validation of immunoassays for the candidate renal markers C-reactive protein, immunoglobin G, thromboxane B2 and retinol binding protein in canine urine. Vet. Immunol. Immunopathol. 2010, 134, 259-264.
• 23. Marchewka Z.: Low molecular Weight Biomarkers in the Nephrotoxicity. Adv. Clin. Exp. Med. 2006, 15, 1129-1138.
• 24. McKenzie J. K., Patel R., McQueen E. G.: The excretion rate of Tamm Horsfall Urinary mucoprotein in normals and in patients with renal disease. Aust. Ann. Med. 1964, 13, 13-39.
• 25. Moriguchi J., Ezaki T., Tsukahara T., Furuki K., Fukui Y., Okamoto S., et al.: Comparative evaluation of four urinary tubular dysfunction markers with special references of aging and correction for creatinine concentration. Toxicol. Lett. 143, 279-290.
• 26. Nabity M. B., Lees G. E., Cianciolo R., Boggess M. M., Steiner J. M., Suchodolski J. S.: Urinary biomarkers of renal disease in dogs with X-linked hereditary nephropathy. J. Vet. Intern. Med. 2012, 26, 282-293.
• 27. Nabity M. B., Lees G. E., Dangott L. J., Cianciolo R., Suchodolski J. S.: Proteomic analysis of urine from male dogs during early stages of tubulointerstitial injury in a canine model of progressive glomerular disease. Vet. Clin. Pathol. 2011, 40, 222-236.
• 28. Nguyen M. T., Devarajan P.: Biomarkers for the early detection of acute kidney injury. Pediatr. Nephrol. 2008, 23, 2151-2157.
• 29. Patel R., McKenzie J. K., McQueen E. G.: Tamm-Horsfall Urinary Mucoprotein and Tubular Obstruction by Casts in Acute Renal Failure, Lancet 1964, 1, 457-461.
• 30. Polzin D. J., Osborne C. A., Adams L. D., O’brien T. D.: Dietary management of canine and feline chronic renal failure. Vet. Clin. North. Am. Small Anim. Pract. 1989, 19, 539-560.
• 31. Raila J., Aupperle H., Raila G., Schoon A., Schweigert F. J.: Renal Pathology and urinary protein excretion in a 14-mont-old bernese mountain dog with chronic renal failure. J. Vet. Med. 2007, 54, 131-135.
• 32. Raila J., Brunnberg L., Schweigert F. J., Kohn B.: Influence of kidney function on urinary excretion of albumin and retinol-binding protein in dogs with naturally occuring renal disease. AJVR 2010, 71.
• 33. Raila J., Buchholz J., Aupperle H., Raila G., Schoon H., Schweigert F.: The distribution of vitamin A and Retinol Binding Protein in blood plasma, urine, liver and kidneys of carnivore. Vet. Res. 2002, 33, 299-311.
• 34. Raila J., Forterre S., Kohn B.: Effect of chronic renal disease on the transport of vitamin A in plasma and urine in dogs. Am. J. Vet. Res. 2003, 64, 874-879.
• 35. Raila J., Neumann U., Schweigert F. J.: Immunochemical localization of megalin, retinol-binding protein and Tamm-Horsfall Glycoprotein in the kidneys of dogs. Vet. Res. Commun. 2003, 27, 125-135.
• 36. Rash R., Torffvit O., Bachmann S., Jensen P. K., Jacobsen N. O.: TammHorsfall glycoprotein in streptozotocin diabetes rats: a study of kidney in situ hybridization, immunohistochemistry, and urinary excretion. Daibetologia 1995, 38, 525-535.
• 37. Romero M. C., Zanaro N., Gonzales L., Trigo P., Imventarza O., Nesse A.: Tamm-Horsfall protein excretion to predict the onset of renal insufficiency. Clin. Biochem. 2002, 35, 65-68.
• 38. Schrier R. W., Wang W., Poole B., Mitra A.: Acute renal failure: definition, diagnosis, pathogenesis, and therapy. J. Clin. Invest. 2004, 114, 5-14.
• 39. Smets P. M. Y., Meyer E., Maddes B. E. J., Duchateau L., Daminet S.: Urinary markers in Healthy young and aged dogs and dogs with chronic kidney disease. J. Vet. Intern. Med. 2010, 24, 65-72.
• 40. Storch S., Saggi S., Megyesi J., Price P. M., Safirstein R.: Ureteral obstruction decreases renal preproepidermal growth factor and Tamm-Horsfall expression. Kidney Int. 1992, 42, 89-94.
• 41. Sundaram M., Aalten D., Findlay J., Sivaprasadarao A.: The transfer of transthyretin and receptor-binding properties from the plasma retinol-binding protein to the epididymal retinoic acid-binding protein. Biochem. J. 2002, 362, 265-269.
• 42. Tarek M., El-Achkar M. D., Xue-Ru Wu M. D.: Uromodulin in kidney injury: an instigator, bystander, or protector? Am. J. Kidney Dis. 2012, 59, 452-461.
• 43. Thornley C., Dawnay A., Cattel W. R.: Human Tamm-Horsfall glycoprotein: urinary and plasma levels in normal subjects and patients with renal disease determined by fully validated radioimmunoassay. Clin. Sci. (Lond.) 1985, 68, 529-535.
• 44. Thulesen J., Jorgensen P. E., Torffvit O., Nexo E., Poulsen S. S.: Urinary excretion of epidermal growth factor and Tamm-Horsafll protein in three rat models with increased renal excretion of urine. Regul. Pept. 1997, 7292, 179-186.
• 45. Torffvit O., Jorgensen P. E., Kamper A. L., et al.: Urinary excretion of TammHorsfall protein and epidermal growth factor in chronic nephropathy. Nephron 1998, 79, 167-172.
• 46. Torffvit O., Melander O., Hulten U. L.: Urinary excretion rate of Tamm-Horsfall protein in related to salt intake in humans. Nephron Physiol. 2004, 97, 31-36.
• 47. Trof R. J., Di Maggio F., Leemreis J., Groeneveld A. B. J.: Biomarkers of acute renal injury and renal failure. Shock 2006, 26, 245-253.
• 48. Vinge L., Lees G. E., Nielsen R., et al.: The effect of progressive glomerular disease on megalin-mediated endocytosis in the kidney. Nephrol. Dial. Transplant. 2010, 25, 2458-2467.
• 49. Westhuyzen J., Endre Z. H., Reece G., Reith G. M., Saltissi D, Morgan T. J.: Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit. Nephrol. Dial. Transplant. 2003, 18, 543-551.
• 50. Yalcin, Cetin M.: Electrophoretic separation of urine proteins of healthy dogs and dogs with nephropathy and detection of some urine proteins of dogs using immunoblotting. Revue Med. Vet. 2004, 155, 104-112.
• 51. Yamada K., Matsuoka Y., Yamamoto A., Kawana T., Ishii K., Ishimi Y., Ikegami S.: Elevation of plasma retinol binding protein concentration in experimental acute renal failure. Nutr. Res. 1997, 17, 1555-1567.
• 52. Ying W. Z., Sanders P. W.: Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats. Kidney Int. 1998, 54, 1150-1156.
• 53. Zaragoza C., Barrera R., Centeno F. et al.: Canine pyometra: a study of the urinary proteins by SDS-PAGE and Western blot. Theriogenology 2004, 61, 1259-1272.
• 54. Zaragoza C., Barrera R., Centeno F.: Characterization of renal damage in canine leptospirosis by sodium dodecyl sulphatepolyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting of the urinary proteins. J. Comp. Pathol. 2003, 129, 169-178.
• 55. Zaragoza C., Barrera B., Centeno F.: SDS-PAGE and Western blot of urinary proteins in dogs with leishmaniasis. Vet. Res. 2003, 34, 137-151.
• 56. Zini E., Bonfanti U., Zatelli A.: Diagnostic relevance of qualitative proteinuria evaluated by use of sodium dedecyl sulfate-agarose gel electrophoresis and comparison with renal histologic finding in dogs. Am. J. Vet. Res. 2004, 65, 694-971.

Identyfikatory

DOI

10.21521/mw.6449