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2020 | 76 | 09 |
Tytuł artykułu

Utility of urinary markers in the assessment of renal dysfunction in dogs with chronic kidney disease

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Chronic kidney disease is a common and clinically significant disease. This complication leads to a decrease of the glomerular filtration rate and in consequence causes azotaemia and uraemia. The objective of this study was to assess the localization and extent of renal damage in dogs with stage-3 chronic kidney disease using a urinary marker for glomerular dysfunction, proximal tubular dysfunction and distal tubular dysfunction (uIgG, uRBP and uTHP, respectively). The examination was performed in twelve dogs affected in stage-3 chronic kidney disease and ten clinically healthy dogs (female and male of comparable age). The levels of urinary biomarkers were measured by commercially available ELISA-tests. In the infected animals a significant renal excretion of HMW protein uIgG and LMW protein uRBP was observed, indicating a dysfunction of the glomerular and tubular regions of the kidneys. Lower levels of uTHP in dogs with CKD was noticed, which may suggest impaired distal tubular regions of the kidneys.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
76
Numer
09
Opis fizyczny
p.525-528,ref.
Twórcy
  • Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland
Bibliografia
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Typ dokumentu
Bibliografia
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