Protective effects of hydrogen on oxidative stress and liver function during CO2 pneumoperitoneum in dogs

• Autorzy: Zhang J. , Zheng X. , Jiang L. , Tao Z. , Liu T.
• Języki publikacji: EN

Abstrakty

EN

The purpose of this study was to investigate the protective effects of hydrogen reducing ischemia-reperfusion injury during CO2 pneumoperitoneum on oxidative stress and liver function. Eighteen healthy Beagle dogs were divided into three groups. Dogs in the control group were subjected only to anesthesia for 90 min. The pneumoperitoneum group was subjected to the pressure of CO2 pneumoperitoneum with 12 mmHg intraabdominal pressure for 90 min. The hydrogen group was subjected to the pressure of CO2 pneumoperitoneum with 12 mmHg intra-abdominal pressure for 90 min after a subcutaneous injection of hydrogen gas (0.2 mL/kg) for 10 min. Blood samples were collected before the induction of pneumoperitoneum, as well as 2 h and 6 h after deflation, to evaluate oxidative stress and liver function in serum. Liver tissue samples were taken 6 h after deflation for histopathological examination. In comparison with group P, a milder histopathological change was found in group H2, and the levels of hepatic function and anti-oxidation in group H2 were higher. Hydrogen gas reduced liver ischemia-reperfusion injury due to CO2 pneumoperitoneum by reducing oxidative stress and improving liver function. Hydrogen gas therapy can be considered as a way to reduce liver ischemiareperfusion injury in laparoscopic surgery.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2020
• Tom: 76
• Numer: 10
• Opis fizyczny: p.589-592,fig.,ref.

Twórcy

autor

Zhang J.

• College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
• China and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Harbin 150030, China

autor

Zheng X.

• College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
• China and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Harbin 150030, China

autor

Jiang L.

• College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
• China and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Harbin 150030, China

autor

Tao Z.

• College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
• China and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Harbin 150030, China

autor

Liu T.

• College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
• China and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Harbin 150030, China

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Identyfikatory

DOI

10.21521/mw.6459