Fat resistin and adiponectin mRNA expression is modulated by glucocorticoids in mice

• Autorzy: Zubel J. , Pierzchala-Koziec K. , Oclon E. , Latacz A.
• Języki publikacji: EN

Abstrakty

EN

It is known that obesity is associated with a state of chronic low-level inflammation. Some data indicate that obesity- related stress could increase the hypothalamo-pituitary-adrenal axis activity. This leads to a rise in the plasma glucocorticoid level, which induces the development and differentiation of preadipocytes. Thus, the present study was performed to examine the effect of glucocorticoids on the expression of resistin and adiponectin mRNAs in adipose tissue during acute and chronic inflammation in mice. The results of the study showed an increase in the expression of resistin mRNA and a decrease in the expression of adiponectin mRNA during chronic inflammation (obese animals). Synthetic glucocorticoids changed the expression of both adipokines in a different manner according to the state of inflammation. To sum up, the action of glucocorticoids in adipose tissue depends on the immune system activity.

• Wydawca: -
• Czasopismo: Acta Biologica Cracoviensia. Series Zoologia
• Rocznik: 2012
• Tom: 54
• Opis fizyczny: p.29-32,fig.,ref.

Twórcy

autor

Zubel J.

• Department of Animal Physiology and Endocrinology, University of Agriculture, Al.Mickiewicza 24/28, 30-059 Krakow, Poland

autor

Pierzchala-Koziec K.

• Department of Animal Physiology and Endocrinology, University of Agriculture, Al.Mickiewicza 24/28, 30-059 Krakow, Poland

autor

Oclon E.

• Department of Animal Physiology and Endocrinology, University of Agriculture, Al.Mickiewicza 24/28, 30-059 Krakow, Poland

autor

Latacz A.

• Department of Animal Physiology and Endocrinology, University of Agriculture, Al.Mickiewicza 24/28, 30-059 Krakow, Poland

Uwagi

PL

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