Galanin affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in haemorrhaged rats

• Autorzy: Ciosek J. , Cisowska A. , Dabrowski R.
• Języki publikacji: EN

Abstrakty

EN

The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats. Gal i.c.v. treatment did not alter vasopressin and oxytocin content both in the hypothalamus and neurohypophysis as well as their concentration in blood plasma of not haemorrhaged rats. Haemorrhage decreased the hypothalamic and neurohypophysial vasopressin and oxytocin storage but increased the neurohormones plasma level in animals injected with vehicle solution. During the haemorrhage, the increase in plasma vasopressin and oxytocin was inhibited in rats previously treated i.c.v. with galanin. The hypothalamic and neurohypophysial vasopressin as well as oxytocin content significantly increased in animals treated with galanin and subsequently haemorrhaged. These results suggest that galanin may have a regulatory role in the hypothalamo-neurohypophysial function especially under condition of hypovolemia.

Słowa kluczowe

EN

neuropeptide galanin; hypovolemia; galanin; hypothalamo-neurohypophysial system; blood plasma; vasopressin; hemorrhage; amino acid; central nervous system; peripheral tissue

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2003
• Tom: 54
• Numer: 2
• Opis fizyczny: p.233-246,fig.

Twórcy

autor

Ciosek J.

• Medical University of Lodz, Narutowicza 60, 90-136 Lodz, Poland

autor

Cisowska A.

autor

Dabrowski R.