Objawy kliniczne, parametry hematologiczne i biochemiczne krwi u swin w przebiegu eksperymentalnej nadczynnosci tarczycy

• Autorzy: Noszczyk-Nowak A , Paslawska U. , Skrzypczak P. , Nicpon J. , Gajek J. , Zysko D.

Warianty tytułu

EN

Symptoms, biochemical and hematological blood parameters in pigs in the course of experimental hyperthyroidism

• Języki publikacji: PL

Abstrakty

EN

The aim of the study was to determine changes in the clinical image and biochemical and hematological blood parameters in pigs during the course of experimental hyperthyroidism. The research material included 10 pigs of the Wielka Bia³a Zwis³oucha breed. Experimental hyperthyroidism was produced by administering oral L-thyroxin at a dose of 20 µg/kg m.c. 1× day in 5 pigs for 8 weeks. The blood for biochemical and hematological investigations (AST, ALT, urea, creatinine, Na⁺, K⁺, Ca⁺⁺, Cal˙, Mg⁺⁺, TSH, FT₃, FT₄) was collected 4 times from the ear’s vein. Changes in swine behavior were observed: increase mobility, rapid tiredness and aggression. Hyperthyroidism caused a statistically significant increase in weight, temperature and heart rate and there was also a statistically significant increase in the amount of creatinine in blood plasma and thyroid hormone activity. There were no statistically significant biochemical and hematological blood parameters in either of the groups of swine.

Słowa kluczowe

PL

wskazniki biochemiczne; objawy chorobowe; trzoda chlewna; badania krwi; nadczynnosc tarczycy; wskazniki hematologiczne

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 02
• Opis fizyczny: s.219-223,rys.,tab.,bibliogr.

Twórcy

autor

Noszczyk-Nowak A

• Uniwersytet Przyrodniczy, pl.Grunwaldzki 47,50-366 Wroclaw

autor

Paslawska U.

autor

Skrzypczak P.

autor

Nicpon J.

autor

Gajek J.

autor

Zysko D.

Bibliografia

• 1. Burggraaf J., Tulen J., Lalezari S., Schoemaker R., de Meyer P., Meinders A., Cohen A., Pijl H.: Sympathovagal imbalance in hyperthyroidism. Am. J. Physiol. Endocrinol. Metab. 2001, 281, E190-E195.
• 2. Braunwald E., Zipes D., Libby P.: Heart Disease. Saunders W. B. Co., New York 2001, 659-774, 815-889, 2151-2171.
• 3. Colzani R. M., Emdin M., Conforti F., Passino C., Scarlattini M., Iervasi G.: Hyperthyroidism is assaciated with lengthening of ventricular repolarization. Clin. Endocrinol. 2001, 55, 27-32.
• 4. Dudley S. C., Baumgarten C. M.: Bursting of cardic sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine. Circ. Res. 1993, 73, 301-313.
• 5. Gajek J., Zięba I., Zyśko D.: Studies on the relationship between beta-adrenergic receptor density on cell wall lymphocytes, total serum catecholamine level and heart rate in patients with hyperthyroidism. Pol. Merkuriusz Lek. 2000, 9, 541-543.
• 6. Górnicki B., Pawlikowski T.: Endokrynologia kliniczna wieku rozwojowego. PZWL Warszawa 1974, 108-117.
• 7. Kahaly G. J., Dillmann W. H.: Thyroid hormone action in the heart. Endocrine Rev. 2005, 4, 1-47.
• 8. Morovat A., Dauncey M. J.: Regulation of porcine skeletal muscle nuclear 3,5,3'-tri-iodothyronine receptor binding capacity by thyroid hormones: modification by energy balance. J. Endocrinology 1995, 144, 233-242.
• 9. Moustaghfi A., Kharchafi A., Belmejdoub G., Chaari J., Ghafir D., Hda A., Ohayon V., Archane M.: Cardiothyrotoxicosis in young adult in Basedow disease: raport of 30 cases. Ann. Cardiol. Angiol. 2000, 49, 161-167.
• 10. Nicpoń J., Janeczko K., Popiel J., Kuryszko J.: Epifizjoliza u świń. Medycyna Wet. 1995, 51, 279-282.
• 11. Nicpoń J., Janeczko K., Popiel J., Kuryszko J., Kuropka P.: Próba wywołania epifizjolizy przy użyciu preparatu Thiamazol. Medycyna Wet. 1999, 55, 101-106.
• 12. Olshausen K., Bischoff S., Kahaly G.: Cardiac arrhythmias and heart rate in hyperthyroidism. Am. J. Cardiol. 1989, 63, 930-935.
• 13. Petretta M., Bonaduce D., Spinelli L., Vicario M., Nuzzo V., Marciano F., Camuso P., Sanctis V., Lupoli G.: Cardiovascular haemodynamics and cardiac autonomic control in patients with subclinical and overt hyperthyroidism. Eur. J. Endocrinol. 2001, 145, 691-696.
• 14. Shimoni Y., Severson D. L.: Thyroid status and potassium currents in rat ventricular myocyte. Am. J. Physiol. 1995, 268, H 576-583.
• 15. Suarez W., Van Hare G., Wexler I., Arnold J.: Atrial Flutter: an uncommon pediatric manifestation of hyperthyroidism. Pediatrics 1997, 100, 1-4.
• 16. Ślebodziński A.: Endokrynologia zwierząt domowych. PWN, Warszawa 1970, 80-97.
• 17. Queiroz M., Shao Y., Berkich D., Lanoue K., Ismail-Beigi F.: Thyroid hormone regulation of cardiac bioenergetics:role of intracellular creatine. Am. J. Physiol. Heart Circ. Physiol. 2002, 283, H2527-H2533.
• 18. Winnicka A.: Wartości referencyjne podstawowych badañ laboratoryjnych w weterynarii. SGGW, Warszawa 1997, 17-67.
• 19. Woeber K.: Thyrotoxicosis and the heart. N. Engl. J. Med. 1992, 327, 94-98.