Opposite influence of MPEP, an mGluR5 antagonist, on the locomotor hyperactivity induced by PCP and amphetamine

• Autorzy: Pietraszek M. , Rogoz Z. , Wolfarth S. , Ossowska K.
• Języki publikacji: EN

Abstrakty

EN

Potential antipsychotic effects of a selective non-competitive antagonist of metabotropic glutamate receptor 5 (mGluR5), 2-methyl-6-phenylethynylpyridine (MPEP), was examined in two commonly used screening tests: (1) the hyperactivity induced by an NMDA receptor antagonist phencyclidine (PCP), and (2) the hyperactivity induced by an indirect dopamine agonist, D-amphetamine. PCP was administered at a dose of 2.5 mg/kg s.c. and D-amphetamine was given at a dose of 1 mg/kg s.c. MPEP (5 mg/kg i.p.) significantly enhanced the locomotor activity increased by PCP, but inhibited amphetamine-induced hyperactivity. The opposite effect of MPEP in the two above-mentioned models questions significance of the blockade of mGluR5 receptors to antipsychotic effects.

Słowa kluczowe

EN

dopaminergic system; metabotropic glutamate receptor 5; phencyclidine; 2-methyl-6-phenylethynylpyridine; locomotor activity; D-amphetamine; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 3
• Opis fizyczny: p.587-593,fig.,ref.

Twórcy

autor

Pietraszek M.

• Polish Academy of Sciences, 12 Smetna Str., 31-343 Krakow, Poland

autor

Rogoz Z.

autor

Wolfarth S.

autor

Ossowska K.