Protein C-mannosylation: facts and questions

• Autorzy: Furmanek A. , Hofsteenge J.
• Języki publikacji: EN

Abstrakty

EN

Among the posttranslational modifications of proteins, glycosylation is probably the most abundant one. Two main types of protein glycosylation have been known for several years, namely N-glycosylation and O-glycosylation. Their biochemical properties, structure and biosynthesis, have been described extensively. Their biological functions are also known for a number of proteins, although in many cases the function remains speculative despite continuous efforts. A few years ago, a new type of protein glycosylation was found, which is different from the above-mentioned ones. It was called C-glycosylation, since the sugar is linked to the protein through a carbon-carbon bond. This article reviews the biochemistry of C-glycosylation, the biosynthetic pathway and structural requirements. Possible biological functions of this modification are also discussed.

Słowa kluczowe

EN

endoplasmic reticulum; C-mannosylation; interleukin; biological function; structure; biochemical property; glycosylation; ribonuclease; biosynthesis; N-glycosylation; protein; O-glycosylation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 3
• Opis fizyczny: p.781-789,fig.

Twórcy

autor

Furmanek A.

• Friedrich Miescher-Institut, Basel, Switzerland

autor

Hofsteenge J.

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