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2006 | 62 | 02 |

Tytuł artykułu

Wplyw acetazolamidu na parametry rownowagi kwasowo-zasadowej oraz elektrolitowej u psow

Warianty tytułu

Języki publikacji

PL

Abstrakty

EN
The aim of study was estimate the effects of acetazolamid administration on arterial acid-base equilibrium and electrolyte concentrations and electrocardiograms in dogs. The study was carried out on 10 mixed-breed dogs, which were administered acetazolamid over 3 days in doses of 30 mg/kg b.w. twice a day. Administration of acetazolamid caused a decrease in pH levels, partial pressure of carbon oxide, bicarbonates in the blood and ions of potassium in the serum. An increase of chloride and sodium concentration in serum was also observed. These results indicate hypochloremic metabolic acidosis associated with hypokalemia. Electrocardiography recordings in the examined dogs were abnormal. Prolonged QT intervals, depression of ST segments and the appearance of a paroxysmal, polymorphous type of ventricular tachycardia were also recorded.

Wydawca

-

Rocznik

Tom

62

Numer

02

Opis fizyczny

s.223-226,rys.,tab.,bibliogr.

Twórcy

  • Uniwersytet Warminsko-Mazurski, ul. Oczapowskiego 14, 10-957 Olsztyn
autor
autor
autor

Bibliografia

  • 1.Akita M., Kuwahara M., Tsubone H., Sugano S.: ECG changes during furosemide-induced hypokalemia in the rat. J. Electrocardiol. 1998, 31, 45-49.
  • 2.Agre P., King L. S., Yasui M., Guggino W. M., Ottersen O. P., Fujiyoshi Y., Engel A., Nielsen S.: Aquaporin water channels from atomic structure to clinical medicine. J. Physiol. 2002, 542, 3-16.
  • 3.Cardenas V. Jr., Heming T., Bidani A.: Kinetics of CO2 excretion and intravascular pH disequilibria during carbonic anhydrase inhibition. J. Appl. Physiol. 1998, 84, 683-694.
  • 4.Chvilicek J. P., Hurlbert B. J., Hill G. E.: Diuretic-induced hypokalemia inducing torsades de pointes. Can. J. Anaesth. 1995, 42, 1137-1139.
  • 5.Doyle D. A., Cabral J. M., Pfuetzner R. A., Kuo A., Gulbis J. M., Cohen S. L., Chait B. T., MacKinnon R.: The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 1998, 280, 69-77.
  • 6.Finley M. R., Lillich J. D., Gilmour R. F., Freeman L. C.: Structural and functional basis for the long QT syndrom: relevance to veterinary patiens. J. Vet. Int. Med. 2003, 17, 473-488.
  • 7.Foglia P. E., Bettinelli A., Tosetto C., Cortesi C., Crosazzo L., Edefonti A., Bianchetti M. G.: Cardiac work up in primary renal hypokalaemia-hypomagne-saemia (Gitelman syndrome). Nephrol. Dial. Transplant. 2004, 19, 1398-1402.
  • 8.Gai X., Taki K., Kato H., Nagaishi H.: Regulation of hemoglobin affinity for oxygen by carbonic anhydrase. J. Lab. Clin. Med. 2003, 142, 414-420.
  • 9.Gelatt K. N., MacKay E. O.: Changes in intaocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. Vet. Ophtalmol. 2001, 4, 61-67.
  • 10.Haskins S. C., Munger R. J., Helphrey M. G., Gilroy B. A., Patz J. D., Steele M. D., Shapiro W.: Effects of acetazolamide in blood acid-base and electrolyte values in dogs. J. Am. Vet. Med. Assoc. 1981, 179, 792-796.
  • 11.Hohne C., Krebs M. O., Seiferheld M., Boemke W., Kaczmarczyk G., Swenson E. R.: Acetazolamide prevents hypoxic pulmonary vasoconstriction in consious dogs. J. Appl. Physiol. 2004, 97, 515-521.
  • 12.Itoh T., Nishimura R., Matsunaga S., Kadosawa T., Mochizuki M., Sasaki N.: Syrigomyelia and hydrocephalus in dog. J. Am. Vet. Med. Assoc. 1996, 209, 934-936.
  • 13.Javaheri S.: Acetazolamide and cerebrospinal fluid ions in dogs with normal acid-base balance. Respir. Physiol. 1987, 69, 257-266.
  • 14.Kohshi K., Kinoshita Y., Fukata K.: Brain pH responses to acetazolamide and hypercapnia in cats. Neurol. Med. Chir. 1997, 37, 313-318.
  • 15.Langberg H., Hartman A., Kiil F.: Inhibitory effect of acetazolamide on renal tubular reabsorpion of NaHCO3 and NaCl in dogs varies invesely with plasma pH. J. Pharmacol. Exp. Ther. 1985, 234, 747-753.
  • 16.Lehtonen J. M., Parkkila S., Vullo D., Casini A., Scozzafava A., Supuran C. T.: Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design. Bioorg. Med. Chem. Lett. 2004, 14, 3757-3762.
  • 17.Maren T. H.: Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol. Rev. 1967, 47, 597-765.
  • 18.Ozaki J., Tanimoto N., Kuse H., Hori M.: Comparison of arterial blood gases and acid-balance in young and aged beagle dogs, with regard to postprandial alkaline tide. J. Toxicol. Sci. 2000, 25, 205-211.
  • 19.Pomianowski A., Kuleta Z., Stopyra A., Sobiech P.: Badania parametrów równowagi kwasowo-zasadowej i składu jonowego we krwi tętniczej, żylnej i włośniczkowej psów zdrowych. Medycyna Wet. 2004, 60, 519-522.
  • 20.Poole-Wilson P. A.: Acidosis and contractility of heart muscle. Ciba Found. Symp. 1982, 87, 58-76.
  • 21.Spitzer K. W., Skolnick R. L., Peercy B. E., Keener J. P., Vaughan-Jones R. D.: Faclitation of intracellular H+ ion mobility by CO2 /HCO3 in rabbit ventricular myocytes is regulated by carbonic anhydrase. J. Physiol. 2002, 541, 159-167.
  • 22.Stokke E. S., Naess P. A., Ostensen J., Langberg H. C., Kiil F.: Plasma potassium concentration as a determinant of proximal tubular NaCl and NaHCO3 reabsorption in dog kidneys. Acta Physiol. Scand. 1993, 148, 45-54.
  • 23.Teppema L. J., Dahan A., Olievier C. N.: Low-dose acetazolamide reduces CO2 -O2 stimulus interaction within the peripheral chemoreceptors in the anaesthetised cat. J. Physiol. 2001, 537, 221-229.
  • 24.Vera Z., Janzen D., Desai J.: Acute hypokalemia and inducibility of ventricular tachyarrhytmia in a nonischemic canine model. Chest. 1991, 100, 1414-1420.
  • 25.Xiang Y., Ma B., Li T., Gao J., Yu H., Li X.: Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis. Acta Pharmacol. Sin. 2004, 25, 812-816.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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