The effect of wortmannin and promoting phorbol ester [TPA] on migration of ovary carcinoma cells

• Autorzy: Miloszewska J. , Szaniawska B. , Kowalczyk D. , Janik P.
• Języki publikacji: EN

Abstrakty

EN

The purpose of the present study was to determine the role of PI 3 kinase in tumor cell migration. The migration of ovary carcinoma cells (OVP10) was strongly inhibited by wortmannin to the same extent as by TPA treatment. The strongest additive inhibitory effect was noted after cell treatment with wortmannin and TPA together. Western blotting studies showed activation / partial down regulation of PKC after TPA treatment and decreased amount of the enzyme following wortmannin exposure. Altogether, it looks like wortmannin inhibits migration of studied cells.

Słowa kluczowe

EN

carcinoma cell; migration; tumour cell; wortmannin; promoting phorbol ester; ovarian carcinoma; cell migration; cell culture

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1999
• Tom: 04
• Numer: 2
• Opis fizyczny: p.175-180,fig.

Twórcy

autor

Miloszewska J.

• Maria Sklodowska-Curie Institute of Oncology, 5,W.K.Roentgen str., 02-781 Warsaw, Poland

autor

Szaniawska B.

autor

Kowalczyk D.

autor

Janik P.

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