Parvalbumin containing neurons of the piriform cortex in open field stress - a developmental study in the rat

• Autorzy: Badowska-Szalewska E , Klejbor I. , Ludkiewicz B. , Luczynska A. , Domaradzka-Pytel B. , Dziewiatkowski J. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

In our study we used c-Fos protein (as a marker of cellular activity) to identify whether cells containing parvalbumin (PV) in the piriform cortex (PC) are engaged in the response to stress stimulation and to discover how this expression changes during maturation. The material consisted of Wistar rats of postnatal (P) ages between 0 and 120 days divided into 9 groups: P0, P4, P7, P10, P14, P21, P30, P90, P120. Each group consisted of 5 experimental and 3 control animals. Rats of the experimental groups were exposed to the “open field test” throughout 10 minutes. The control animals were kept in a home cage. Our results showed that c-Fos activity in the open field test was observed in layers II and III of PC after birth. It then increased and stabilised on P30. In the second week of life PV-positive cells were also observed in those layers. These achieved maturity in the 4th week of life. After this time basket-like structures appeared but the level of PV/c-Fos co-localisation was low. Only small differences were observed between the anterior and posterior parts of PC. In the anterior part a higher number of PV-positive neurons, neuropil threads, and basket-like structures and a larger degree of PV/c-Fos co-localisation were observed. Our results suggested that during maturation PV cells are not directly activated in response to stress stimuli but PV neurons via their numerous endings influence the activation of c-Fos-positive cells predominantly in the anterior part of PC.

Słowa kluczowe

EN

piriform cortex; parvalbumin; c-Fos protein; open field test; maturation; stress; rat

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2004
• Tom: 63
• Numer: 4
• Opis fizyczny: p.367-372,fig.,ref.

Twórcy

autor

Badowska-Szalewska E

• Medical University, Debinki 1, 80-211 Gdansk, Poland

autor

Klejbor I.

autor

Ludkiewicz B.

autor

Luczynska A.

autor

Domaradzka-Pytel B.

autor

Dziewiatkowski J.

autor

Morys J.

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