Determination of nitrofuran metabolite residues in eggs by liquid chromatography-mass spectrometry

• Autorzy: Sniegocki T , Posyniak A. , Zmudzki J.
• Języki publikacji: EN

Abstrakty

EN

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the determination of metabolites of furazolidone, furaltadone, nitrofurantoin, and nitrofurazone in eggs. The procedure requires an acid-catalysed release of protein-bound metabolites, followed by their in situ conversion into the 2- nitrobenzaldehyde (NBA) derivatives. The sample cleanup was performed on a solid phase extraction (SPE) cartridge. LC- MS/MS analysis was performed by positive electrospray ionisation (ESI) applying multiple reaction monitoring (MRM) of two transition reactions for each compound. The validation of the method was conducted following the European Union criteria for the analysis of veterinary drug residues in foods. The decision limits (CCα) were 0.16-0.24 µg/kg, and the detection capabilities (CCβ) 0.22-0.36 µg/ kg.

Słowa kluczowe

EN

mass spectrometry; nitrofuran; residue; food analysis; determination; liquid chromatography; egg; drug residue; veterinary drug; metabolite

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2008
• Tom: 52
• Numer: 3
• Opis fizyczny: p.421-425,fig.,ref.

Twórcy

autor

Sniegocki T

• National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Posyniak A.

autor

Zmudzki J.

Bibliografia

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