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2008 | 52 | 3 |

Tytuł artykułu

Ultrastructural evaluation of pancreatic parenchyma in the course of intoxication with ethanol

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The experiment was performed on rats that were given ethanol ad libitum for 4 weeks. After decapitation of the animals, pancreatic sections were prepared for an electron microscopy. A significant broadening of the rough endoplasmic reticulum cisterns in the vesicular cells was observed as well as the presence of nuclei with irregular outlines resulted from placation of the nuclear membrane, which is worth of attention. Such a picture suggests that the examined cells had a lowered metabolic ability.

Wydawca

-

Rocznik

Tom

52

Numer

3

Opis fizyczny

p.445-447,fig.,ref.

Twórcy

autor
  • Medical University of Lublin, 20-080 Lublin, Poland
autor
autor
autor
autor
autor

Bibliografia

  • 1. Conde de la Rosa L., Moshage H., Nieto N.: Hepatocyte oxidant stress and alcoholic liver disease. Rev Esp Enferm Dig 2008, 100, 156-163.
  • 2. De Minicis S., Brenner D.A.: Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol 2008, 23, S98- S103.
  • 3. Den X., Wang L., Elm M S., Gabazadeh D., Diorio G.J., Eagon P.K., Whitcomb D.C.: Chronic alcohol consumption accelerates fibrosis in response to cerulein - induced pancreatitis in rats. Am J Pathol 2005, 166, 93-106.
  • 4. Gukovsky I., Lugea A., Shahsahebi M., Cheng J.H., Hong P.P., Jung Y.J., Deng Q.G., French B.A., Lungo W., French S.W., Tsukamoto H., Pandol S.J.: A rat model reproducing key pathological responses of alcoholic chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 2008, 294, G68-G79.
  • 5. Gullo L.: Alcohol and chronic pancreatitis: leading or secondary etiopathogenetic role? JOP 2005, 6 (Suppl), 68-72.
  • 6. Kono H., Nakagami M., Rusyn I., Connor H.D., Stefanovic B., Brenner D.A., Mason R.P., Arteel G.E., Thurman R.G.: Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Am J Physiol Gastrointest Liver Physiol 2001, 280, G1178-G1186.
  • 7. Matsumoto H., Matsumoto I.: Alcoholism: protein expression profiles in a human hippocampal model. Expert Rev Proteomics 2008, 5, 321-331.
  • 8. Pedrycz A., Boratyński Z., Kot K., Mendocha J., Rubaj J., Cichacz B., Plaskota W.: Histomorphological evaluation of fibrogenesis in the pancreas after an experimental administration of ethanol. Bull Vet Inst Pulawy 2008, 52, 449-451.
  • 9. Rothman A., Proveribo T., Proveribo F.: Inhibitory effect of ethanol on the Na⁺-ATPase activity of rat kidney proximal tubular cell plasma membranes. Physiol Res 1996, 45, 205-211.
  • 10. Uesugi T., Froh M., Gabele E., Isayama F., Bradford B.U., Ikai I., Yamaoka Y., Arteel G.E.: Contribution of angiotensin II to alcohol-induced pancreatic fibrosis in rats. J Pharmacol Exp Ther 2004, 311, 921-928.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-f26dca1d-c142-4bb2-ad83-c448f092a109
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