The influence of adriamycin on the CD4 and CD8 cells in the course of trichinellosis in mice

• Autorzy: Karmanska K , Houszka M. , Mista D. , Stefaniak E.
• Języki publikacji: EN

Abstrakty

EN

The effect of adriamycin on the behaviour of CD4⁺ and CD8⁺ cells in the course of trichinellosis in mice has been studied. The animals infected with 200 larvae per mouse were administered intraperitoneally adriamycin (Adriblastin from Farmitalia) at 1st and 28th day post infection (dpi), in a dosis of 0.2 mg. The mice were killed weakly for 6 weeks and then at the 60th dpi. The examinations were made on histologic sections from the spleen, mesenteric lymph node, jejunum and masseter muscle using immunofluorescent and immunoenzymatic methods with monoclonal antibody. The mice receiving adriamycin exhibited more CD8⁺ cells in the intestinal mucosa and by the end of the experiment also in the muscles in comparison with the control animals, which, however, did not affect the course of the infection.

Słowa kluczowe

EN

parasite; mouse; mice; cell; trichinellosis; adriamycin; histopathology

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 1994
• Tom: 40
• Numer: 4
• Opis fizyczny: p.363-367,fig.,ref.

Twórcy

autor

Karmanska K

• Polish Academy of Sciences, 50-337 Wroclaw, ul.Norwida 31, Poland

autor

Houszka M.

autor

Mista D.

autor

Stefaniak E.

Bibliografia

• DIAZ-SANCHEZ D., KEMENY D. M. 1991. Generation of a long-lived IgE response in high and low responder strains of rat by coadministration of ricin and antigen. Immunology 72: 297-303.
• -., LEE T. H., KEMENY D. M. 1993. Ricin enhances IgE responses by inhibiting a subpopulation of early-activated IgE regulatory CD8⁺ T cells. Ibid. 78: 226-236.
• EHRKE M. J., COHEN S. A., MIHICH E. 1982. Selective effects of adriamycin on murine host defense system. Immunol. Rev. 65: 55-78.
• FINKELMAN F. D. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev. Immun. 8: 303-333.
• KARMAŃSKA K.., HOUSZKA M., MIŚTA D., STEFANIAK E. CD4⁺ and CD8⁺ cells in Trichinella spiralis infection of mice. Acta Parasitol. (in press).
• KOZAR Z., KOZAR M. 1972. Diagnostyka chorób pasożytniczych człowieka. PZWL, Warszawa.
• LANE PETTER W., PEARSON A. E. G. 1971. The laboratory animal - Principles and practice. Academic Press, London - New York.
• LITWIN J. A. 1990. Metody immunoenzymatyczne. In: Immunocytochemia [M. ZABEL ed.] PWN, Warszawa: 65-91.
• MACCUBBIN D. L., WHITMAN J. A., TANIGUCHI N., MACE K. F., EHRKE M. J., MIHICH E. 1988. Comparison of adriamycin induced immunomodulation with that of the noncardiotoxic anthracycline 5-iminodaunorubicin. Int. J. Immunopharmac. 10: 317-323.
• MANTOVANI A., VECCHI A., TAGLIABUE A., SPREAFICO F. 1976. The effect of adriamycin and daunomycin on antitumoral immune effector mechanisms in an allogeneic system. Eur. J. Cancer 12: 371-379.
• ORSINI F., MIHICH E. 1975. Immunosuppression by adriamycin (AM) and daunorubicin (DM). Proc. Amer. Assoc. Cancer Res. 16: 130-136.
• -., PAVELIC Z., MIHICH E. 1977. Increased primary cell mediated immunity in culture subsequent to adriamycin of daunorubicin treatment of spleen donor mice. Cancer Res. 37: 1719-1726.
• SEDGWICK J. D., HOLT P. G. 1985. Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph node of rats in response to antigen inhalation. Cell Immunol. 94: 182-194.
• SCHWARTZ H. S., GRINDEY G. B. 1973. Adriamycin and daunorubicin: a comparison of antitumor activities and tissue uptake in mice following immunosuppression. Cancer Res. 33: 1837-1844.
• TUOMAZIC V., EHRKE M. J., MIHICH E. 1981. Augmentation of the development of immune responses of mice against allogeneic tumor cell after adriamycin treatment. Ibid. 44: 3370-3376.
• VECCHI A., MANTOVANI A., TAGLIABUE A., SPREAFICO F. 1976. A characterization of immunosuppressive activity of adriamycin and daunomycin on humoral antibody production and tumor allograft rejection. Ibid. 36: 1222-1227.
• ŻEROMSKI J. 1990. Metody immunofluorescencyjne. In: Immunocytochemia [M. ZABEL ed.] PWN, Warszawa: 92-120.