Morphological and immunological characterization of immunostimulatory complexes based on glycoglycerolipids from Laminaria japonica

• Autorzy: Lee I. A. , Popov A.M. , Sanina N.M. , Kostetsky E.Y. , Novikova O.D. , Reunov A.V. , Nagorskaya V.P. , Shnyrov V.L.
• Języki publikacji: EN

Abstrakty

EN

Some physicochemical properties of glycoglycerolipids (monogalactosyldiacyl- glycerol, digalactosyldiacylglycerol and sulfoquinovosyldiacylglycerol) from the sea algae Laminaria japonica, as well as their ability to become incorporate into immunostimulating complexes (ISCOMs), used as a delivery system of microbial and tumor antigens in vesicular form, were studied. These glycolipids were found to dif­fer essentially in fatty acid composition, unsaturation index and thermotropic behav­ior. The possibility of ISCOM modification by embedding the glycolipids studied in­stead of a phospholipid component in vesicles was shown. A preliminary research of the immunogenicity of the pore-forming protein from Yersinia pseudotuberculosis in modified (by monogalactosyldiacylglycerol) and typical (egg phosphatidylcholine) ISCOMs did not reveal a significant enhancement of immune response in compari­son with that of isolated protein.

Słowa kluczowe

EN

Laminaria japonica; physicochemical property; glycoglycerolipid; sea alga; immunostimulatory complex; pore-forming protein

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 1
• Opis fizyczny: p.263-272,fig.,ref.

Twórcy

autor

Lee I. A.

• Pacific Institute of Bioorganic Chemistry FEBRAS, pr.100 let Vladivostoku, 690022 Vladivostok, 159, Russia

autor

Popov A.M.

autor

Sanina N.M.

autor

Kostetsky E.Y.

autor

Novikova O.D.

autor

Reunov A.V.

autor

Nagorskaya V.P.

autor

Shnyrov V.L.

Bibliografia

• Adamus G, Mulczyk M, Witkowska D, Romanowska E. (1980) Protection against keratoconjunctivitis shigellosa induced by immunization with outer membrane proteins of Shigella spp. Infect Immun.; 30: 321-4.
• Bakouche O, Gerlier D. (1986) Enhancement of immunogenicity of tumour virus antigen by liposomes: the effect of lipid composition. Immunology.; 58: 507-13.
• Buchanan TM, Arko RJ. (1977) Immunity to gonococcal infection induced by vaccination with isolated outer membranes of Neisseria gonorrhaeae in guinea pigs. J Infect Dis.; 135: 879-87.
• Ennis FA, Cruz J, Jameson J, Klein M, Burt D, Thipphawong J. (1999) Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carries (ISCOMs). Virology.; 259: 256-61.
• Folch J, Lees M, Sloane Stanley GH. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem.; 226: 497-509.
• Fujii S, Shimizu K, Smith C, Bonifaz L, Steinman RM. (2003) Activation of natural killer T cells by alpha- galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med.; 198: 267-79.
• Gustafson KR, Cardellina JH, Fuller RW, Weislow OS, Kiser RF, Shader KM, Patterson GM, Boyd MR. (1998) AIDS- antiviral sulfolipids from cyanobacteria blue-green algae. J Natl Cancer Inst.; 81: 1254-8.
• Karch H, Nixdorff K. (1981) Antibody-producing cell responses to an isolated outer membrane protein and to complexes of this antigen with lipopolysaccharide or with vesicles of phospholipids from Proteus mirabilis. Infect Immun.; 31: 862-7.
• Kersten GFA, Teerlink T, Derks HJGM, Verkleij AJ, van Wezel TL, Crommelin DJA, Beuvery EC. (1988) Incorporation of the major outer membrane protein of Neisseria gonorrhaeae in saponin-lipid complexes (Iscoms): chemical analysis, some structural features and comparison of their immunogenicity with three other antigen delivery systems. Infection Immunity.; 56: 432-8.
• Kersten GFA, Crommelin DJA. (1995) Liposomes and ISCOMs as vaccine formulations. Biochim Biophys Acta.; 1241: 117-38.
• Kersten GFA, Crommelin DJA. (2003) Liposomes and ISCOMs. Vaccine.; 21: 915-20.
• Khotimchenko SV. (1993) Fatty acids and polar lipids of sea grasses from the Sea of Japan. Photochemistry.; 33: 369-72.
• Lowry OH, Rosebrough OH, Farr NJ, Randall RJ. (1951) Protein measurements with Folin phenol reagent. J Biol Chem. ; 193: 265-75.
• Lovgren K, Morein B. (1988) The requirement of lipids for the formation of immunostimulating complexes (ISCOMs). Biotechnol Appl Biochem.; 10: 161-72.
• Loya S, Reshef V, Mizrachi E, Silberstein C, Rachamim YCS, Hizi A. (1998) The inhibition of the reverse transcriptase of HIV-1 by the natural sulfoglycolipids from cyanobacteria: contribution of different moieties to their high potency. J Nat Prod.; 61: 891-5.
• Lychatskaya GN, Novikova OD, Solovjeva TF, Ovodov YuS. (1985) Isolation pore-forming protein from outer membrane Yersinia pseudotuberculosis and study its effects on conductivity of bilayer membranes. Biol Membr.; 2: 1219-24.
• Matsumoto G, Nagai S, Muta M, Tsuruta K, Okamoto A, Toi M. (2003) Survival benefit of KRN7000 immune therapy in combination with TNP470 in hamster liver metastasis model of pancreatic cancer. Oncol Rep.; 10: 1201-06.
• Mohamedi SA, Heath AW, Jenings RA. (2001) Comparison of oral and parenteral routes for therapeutic vaccination with HSV-2 ISCOMs in mice; cytokine profiles, antibody responses and protection. AntivirRes.; 49: 83-99.
• Morein B, Hu K&-F. (2000) Biological aspects and prospects for adjuvants and delivery systems. In New Vaccine Technologies. Ronald W, ed, pp 274-91.
• Morein B, Sundquist B, Hoglund S, Dalsgaard K, Osterhaus A. (1984) Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature.; 308: 457-60.
• Morimoto T, Nagatsu A, Murakami N, Sakakibara J, Tokuda H, Nishino H, Iwashima A. (1995) Antitumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris. Photochemistry.; 40: 1433-7.
• Novikova OD, Frolova GM, Vakorina TN, Tarankova ZA, Glazunov VP, Solovjeva TF, Ovodov YS. (1989) Conformational stability and immunochemical properties of yersinin — the basic protein external membrane pseudo- tubercular microbe. Bioorg Khim.; 15: 763-8.
• Novikova OD, Vostrikova OP, Portnyagina OY, Khomenko VA, Solovjeva TF, Ovodov YS. (1996) Antigenic properties of pore protein of outside membrane genus Yersinia. Biull Eksp Biol Med.; 121: 657-60.
• Ohta K, Mizushina Y, Hirata N, Takemura M, Sugawara F, Matsukage A, Yoshida S, Sakaguchi K. (1998) Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella. Chem Pharm Bull (Tokyo).; 46: 684-6.
• Pinxteren van LAH, Bruce MG, Campbell I, Wood A, Clarke CJ, Bellman A, Morein B, Snodgrass DR. (1999) Effect of oral rotavirus/iscom vaccines on immune responses in gnotobiotic lambs. Vet Immunol Immunopathol.; 71: 53-67.
• Portnyagina OY, Novikova OD, Vostrikova OP, Solovjeva TF. (1999) Dynamics of immune response to pore protein from Yersinia pseudotuberculosis outside membrane. Biull Eksp Biol Med.; 128: 437-40.
• Sanina NM, Forster G, Hubner W, Blume A. (2002) Phase behavior of glycolipids from marine macrophytes. Chem Phys Lipids.; 118: 63-4.
• Sanina NM, Goncharova SN, Kostetsky EY. (2003) Seasonal changes in thermotropic behavior of phospho&- and glycolipids from Laminaria japonica. In Advanced Research on Plant Lipids. Murata et al, eds, pp 385-8. Kluwer Academic Publishers, Dordrecht.
• Singleton WS, Gray MS, Brown MZ, White GZ. (1965) Chromatographically homogenous lecithin from egg phospholipids. J Am Oil Chem Soc.; 42: 53-6.
• Vaskovsky VE, Khotimchenko SV. (1982) HPTLC of polar lipids of algae and other plants. J High Resol Chromatogr.; 5: 635-6.