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2007 | 63 | 01 |

Tytuł artykułu

Przerost serca wyzwalany podaniem L-tyroksyny per os u rosnacych swin

Warianty tytułu

EN
Cardiac hypertrophy induced by administration oral of L-thyroxine in growing pigs

Języki publikacji

PL

Abstrakty

EN
The aim of the experiment was to evaluate the influence of oral administration of L-thyroxine on the heart. The research material included 8 pigs of the polska bia³a zwis³oucha breed. The experimental hyperthyroidism was induced by oral administration of L-thyroxine at a dose 20 µg/kg b.w. in 4 pigs. The echocardiography examination was carried out 3 times in each pig: before hyperthyroidism outset and twice in hyperthyroxinemia. Through echocardiographic examination a statistically significant increase in LWd was stated. An increase in IVSd, decrease in LVd and a statistically significant increase in relative wall thickness and left ventricular mass in the group of pigs administered L-tyroxine was observed. A statistically significant decrease in SF connected with an increase in the left ventricle wall thickness occurred as well. The performed autopsy revealed an increased thickness of the right and left heart ventricles in swine with the experimental hyperthyroidism. It was stated that hyperthyroxinemia induces heart muscle hypertrophy which concerns mainly the ventricular muscles. Observed secondary hypertrophic cardiomyopathy may be the consequence of hyperthyroxinemia.

Wydawca

-

Rocznik

Tom

63

Numer

01

Opis fizyczny

s.113-117,rys.,tab.,bibliogr.

Twórcy

  • Akademia Rolnicza, pl.Grunwaldzki 47, 50-366 Wroclaw
autor
autor
autor
autor

Bibliografia

  • 1. Basset A., Blanc J., Elghozi J.: Contribution of renin-angiotensin system to blood pressure variability in hyperthyroid rats. Arch. Mal. Coeur. Vaiss. 2000, 93, 905-910.
  • 2. Biondi B., Palmieri E., Lombardi G., Fazio S.: Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in regulation cardiac performance in human hyperthyroidism. J. Clin. Endocrin. Metab. 2002, 87, 968-974.
  • 3. Biondi B., Palmieri E., Tremalaterra R., Angellotti G., Bone F., Riccio G., Cittadini A., Lombardi G., Sacca L.: Effects of chronic subclinical hyperthyroidism from levothyroxine on cardiac morphology and function. Cardiologia 1999, 44, 443-449.
  • 4. Braunwald E., Zipes D., Libby P.: Heart Disease. Saunders W. B. Co., New York 2001, 659-774, 815-889, 2151-2171.
  • 5. Cheitlin M., Alpert J., Amstrong W.: ACC/AHA guidelines for the clinical application of echocardiography. Circulation 1997, 95, 1686-1774.
  • 6. Dorr M., Wolff B., Robinson D., John U., Ludemann J., Meng W., Felix S., Volzke H.: The association of thyroid function with cardiac mass and left ventricular hypertophy. J. Clin. Endocrinol. Metab. 2005, 90, 673-677.
  • 7. Foley C., McAllister R., Hasser E.: Thyroid status influences baroreflex function and autonomic contributions to arterial pressure and heart rate. Am. J. Physiol. Heart Circ. Physiol. 2001, 280, H2061-H2068.
  • 8. Harjai K., Licata A.: Effects of amiodarone on thyroid function. Ann. Intern. Med. 1997, 126, 63-73.
  • 9. Kahaly G. J., Dillmann W. H.: Thyroid hormone action in the heart. Endocrine Rev. 2005, 4, 1-47.
  • 10. Kobori H., Ichihara A., Miyashita Y., Hayashi M., Saruta T.: Local reninangiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy. J. Endocrinol. 1999, 160, 43-47.
  • 11. Kuncova J., Slavikova J.: Vasoactive intestinal polypeptide in rat atria: the effect of hyperthyroidism. Physiol. Res. 2000, 49, 427-434.
  • 12. Kobori H., Hayashi M., Saruta T.: Thyroid hormone stimulates renin gen expression throughgt the thyroid hormone response element. Hypertension 2001, 37, 99-110.
  • 13. Petretta M., Bonaduce D., Spinelli L., Vicario M., Nuzzo V., Marciano F., Camuso P., Sanctis V., Lupoli G.: Cardiovascular haemodynamics and cardiac autonomic control in patients with subclinical and overt hyperthyroidism. Eur. J. Endocrinol. 2001, 145, 691-696.
  • 14. Presti C. F., Hart R. G.: Thyrotoxicosis, atrial fibrillation, and embolism, revisited. Am. Heart J. 1989, 117, 996-997.
  • 15. Tracz W., Podolca P., Hoffmana P.: Echokardiografia praktyczna. Tom II. Medycyna Praktyczna, Warszawa 2005, s. 417-429.
  • 16. Yu Y., Bilezikian J.: Tachycardia-induced cardiomyopathy secondary to thyrotoxicosis: a young man with previously unrecognized Graves' disease. Thyroid. 2000, 10, 923-927.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-f13edc14-759d-4311-a8f7-bf7b6b532fd0
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