Aktualne poglady na budowe, funkcjonowanie i znaczenie receptorow glutaminianergicznych typu NMDA

• Autorzy: Kania B F , Cieciera M.

Warianty tytułu

EN

Current views on the structure, molecular function and role of the glutamate receptors NMDA

• Języki publikacji: PL

Abstrakty

EN

The paper reviews the terminology, molecular activity and role of the NMDA glutamate receptors. As excitatory aminoacid receptors these receptors are generally classified as ionotropic (NMDA, AMPA, KA) and metabotropic depending (mGluR₁₋₈) on whether they form ion channels or are coupled to G-proteins, respectively. Recent investigations indicated the essential role of the NMDA receptors in the nociceptive processus modulation. Recent progress has been made in the development of specific antagonists - such as MK-801, araxines, mementine, DL-AP-3, and others - for these receptors, and can siginicantly facilitate prophilaxy and therapy in different types of pain.

Słowa kluczowe

PL

dzialanie; fizjologia zwierzat; receptory NMDA; antagonisci receptorow NMDA; budowa

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 08
• Opis fizyczny: s.896-899,rys.,bibliogr.

Twórcy

autor

Kania B F

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Nowoursynowska 159, 02-776 Warszawa

autor

Cieciera M.

Bibliografia

• 1. Cartmell J., Schoepp D. D.: Regulation of neurotransmitter release by metabotropic glutamate receptors. J. Neurochem. 2000, 75, 889-907.
• 2. Coutinho S. V., Meller S. T., Gebhart G. F.: Intracolonic zymosan produces visceral hyperalgasia in rat that is mediated by spinal NMDA and non-NMDA receptors. Brain Res. 1996, 736, 7-15.
• 3. Czapiński P., Błaszczyk B., Czuczwar S. J.: Mechanisms of action of antiepileptic drugs. Curr. Top Med. Chem. 2005, 5, 3-14.
• 4. Danysz W., Parsons C. G.: Glycine and NMDA receptors - physiological significance and possible therapeutic applications. Pharmacol. Rev. 1998, 50, 597-664.
• 5. Danysz W., Frankiewicz T., Sopala M.: Receptory glutaminianergiczne, [w] Nowak J. Z., Zawilska J. B. (red.): Receptory i mechanizmy przekazywania sygnału. Wydawnictwo Naukowe PWN, Warszawa 2004, 382-412.
• 6. Dickenson A. H.: A cure of wind-up: NMDA receptor antagonists as potential analgesics. TIPS 1990, 11, 307-309.
• 7. Dinglendine R., Borges K., Bowie D., Traynelis S. F.: The glutamate receptor ion channels. Pharmacol. Rev. 1999, 51, 7-61.
• 8. Dolan S., Nolan A. M.: Behavioral evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep. Neuropharmacol. 2002, 43, 319-326.
• 9. Dubner R., Ruda M. A.: Activity-dependent plasticity following tissue injury and inflammation. Trends Neurosci. 1992, 15, 96-103.
• 10. Fundytus M. E., Yashpal K., Chabot J. G., Osborne M. G., Lefebvre C. D., Dray A., Henry J. L., Coderre T. J.: Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats. Br. J. Pharmacol. 2001, 132, 354-367.
• 11. Gaudreau G. A., Plourde V.: Involvement of N-methyl- D- asparate (NMDA) receptors in rat model of visceral hypersensitivity. Behav. Brain Res. 2003, 150, 185-189.
• 12. Harris E. W.: Subtypes of glutamate receptors: pharmacological classification, [w] Stones T. W. (red.): CNS Neurotransmitters and Neuromodulators: Glutamate. CRC Press, Boca Raton FL 1995, 95-125.
• 13. Holman M., Heinemann S.: Cloned glutamate receptors. Ann. Rev. Neurosci. 1999, 17, 31-108.
• 14. Johnson J. W., Ascher P.: Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 1987, 325, 5529-5531.
• 15. Karim F., Bhave G., Gereau R. W.: Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics. Mol. Psychiatry 2001, 6, 615-617.
• 16. Kolhekar R., Gebhart G. F.: NMDA and quisqualate modulation of visceral nociception in the rat. Brain Res. 1994, 651, 215-226.
• 17. Kolhekar R., Gebhart G. F.: Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat. J. Neurophysiol. 1996, 75, 2344-2351.
• 18. Kotlińska-Lemieszek A., Bączyk E., Łuczak J.: Podstawy patofizjologii i diagnostyki bólów nowotworowych. Zespoły bólowe najczęściej występujące u pacjentów w zaawansowanym okresie choroby nowotworowej. Nowa Medycyna 1999, 8, 15-25.
• 19. Laird J. M. A., Garcia de la Rubia P., Cervero F.: Excitability changes of somatic and viscero- somatic nociceptive reflexes in the decerebrate spinal rabbit: role of NMDA receptors. J. Physiol. 1995, 489, 545-555.
• 20. Lerma J., Zukin R. S., Bennett M. V.: Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses. Proc. Nat. Acad. Sci. USA 1990, 87, 2354-2358.
• 21. Liebeskind J. C., Yirmiya R., Marek P.: Neurochemical laterality of the analgesic effect of PAG stimulation in the mouse. Proc. Neurosci. Abstr. 1988, 14, 857.
• 22. Marek P., Mogil J. S., Sternberg W. F., Panocka I., Liebeskind J. S.: N-methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stressinduced analgesia. II. Comparison across three swim stress paradigms in selectively bred mice. Brain Res. 1992, 578, 197-203.
• 23. Marek P.: Rola receptora kwasu N-metyl-D-asparaginowego (NMDA) w procesach analgetycznych i rozwoju zawa³u mózgu. Praca hab., Wydz. Med. Wet. SGGW, Warszawa 2002, 1-22.
• 24. Neugebauer V.: Metabotropic glutamate receptors: novel targets for pain relief. Expert Rev. Neurother. 2001, 1, 207-224.
• 25. Neugebauer V.: Metabotropic glutamate receptors - important modulators of nociception and pain behavior. Pain 2002, 98, 1-8.
• 26. Neugebauer V., Carlton S. M.: Peripheral metabotropic glutamate receptors as drug targets for pain relief. Expert Opin. 2002, 6, 1-13.
• 27. Ozawa S., Kamiya H., Tsuzuki K.: Glutamate receptors in the mammalian central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 1998, 54, 581-618.
• 28. McRoberts J. A., Coutinho S. V., Marvizon J. C. G., Grady E. F., Tognetto M., Sengupta J. N., Ennes H. S., Chaban V. S., Creminon C., Lanthorn T., Geppetti P., Bunnett N. W., Mayer E. A.: Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 2001, 120, 7, 1737-1748.
• 29. Rosenmud C., Stern-Bach Y., Stevens C. F.: The tetrameric structure of a glutamate receptor channel. Science 1998, 280, 1547-1548.
• 30. Urban L., Thompson S. W. N., Dray A.: Modulation of spinal excitability: cooperation between neurokinin and excitatory amino acid neurotransmitters. Trends in Neurosci. 1994, 17, 432-438.
• 31. Weawer C. E. Jr., Marek P., Park-Chuny M., Tam S. W., Farb D. H.: Neuroprotective activity of a new class of steroid inhibitors of the N-methyl-D-aspartate receptor. Proc. Nat. Acad. Sci. USA 1997, 94, 10450-10454.
• 32. Wlaź P.: Przeciwdrgawkowe działanie ligandów miejsca glicynowego w kompleksie receptora NMDA. Praca hab., Wydz. Med. Wet. AR, Lublin 1999, 1-4.
• 33. Yakamura T., Shimoji K.: Subunit and site specific pharmacology of the NMDA receptor channel. Progr. Neurobiol. 1999, 59, 279-298.