The influence of cyclosporin A on the eosinophils, mast cells, B lymphocytes and plasma cells during the course of the muscular phase of trichinellosis in mice

• Autorzy: Karmanska K , Bulla M. , Mista D. , Stefaniak E.
• Języki publikacji: EN

Abstrakty

EN

The influence of Cyclosporin A (CyA) on the course of the muscular phase of trichinellosis in mice was investigated. The animals were infected with 200 Trichinella spiralis larvae and were treated with CyA between the 14th-18th day after infection. The drug was administered at a dose of 50 mg/kg/day. An increase in the number of eosinophils and В lymphocytes was observed relative to the control group. Our results indicate that CyA elicited the secretion of Th2 cell cytokines. At the same time more granulomas and a lower number of muscle larvae were observed in mice treated with CyA.

Słowa kluczowe

EN

plasma cell; B lymphocyte; mouse; mice; cell; trichinellosis; mast cell; eosinophil; muscular phase; cyclosporin A; larva; Trichinella spiralis

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1995
• Tom: 40
• Numer: 1
• Opis fizyczny: p.58-61,fig.

Twórcy

autor

Karmanska K

autor

Bulla M.

autor

Mista D.

autor

Stefaniak E.

Bibliografia

• Bolas-Fernandez F., Grencis R. K., Wakelin D. 1988. Cyclosporin A and Trichinella spiralis: anthelmintic effects in immunosuppressed mice. Parasite Immunology, 10, 111-116.
• Fidelius R. K., Ferguson R. M., Widmer M. B., Wee S. L., Bach F. H., Orosz C. G. 1982. Effect of cyclosporin A on murine and human T helper cell clones. Transplantation, 34, 308-311.
• Finkelman F. D., Pearce E. J., Urban J. F., Jr., Sher A. 1991. Regulation and biological function of helminth-induced cytokine responses. Parasitology Today (Immunoparasitology Today), 7(3), A62-A66.
• Foxwell B. M., Ruffel В. 1990. The mechanisms of action of cyclosporine. Cardiologia Clinics, 8, 107-117.
• Grencis R. K., Bolas-Fernandez F., Wakelin D. 1989. Analysis of cellular immune responses during intestinal infection by Trichinella spiralis in mice treated with Cyclosporin A. Proceedings of the 7th International Conference on Trichinellosis, October 2-6, 1988, Alicante (Spain), 165-170.
• Herold K. C., Lanchi D. W., Moldwin R. L., Fith F. W. 1986. Immunosuppressive effects of Cyclosporine A on cloned T cells. Journal of Immunology, 136, 1315-1321.
• House R., Dean J. H. 1988. Trypanosoma musculi: characterization of the T-lymphocyte dependency of immunity by selective immunomodulation of the mouse, Mus musculus. Experimental Parasitology, 67, 104-115.
• Karmańska K., Houszka M. 1994. Wpływ cyclosporyny A na przebieg mięśniowej fazy włośnicy u myszy. Wiadomości Parazytologiczne, 40, 133-140.
• Karmańska K., Kozar Z. 1969. Occurrence of cells containing globulins in the course of Trichinella spiralis infection in mice. Wiadomości Parazytologiczne, 15, 406-409.
• Karmańska K., Michalska Z. 1985. Rola komórek tucznych w przebiegu włośnicy u myszy. Wpływ surowicy sporządzonej przeciwko mastocytom otrzewnowym i surowicy przygotowanej przeciwko ziarnistościom mastocytów jelitowych. Wiadomości Parazytologiczne, 31, 299-308.
• Karmańska K., Michalska Z., Mielczarek J., Ślaska B. 1987. Dynamika zmian immunopatologicznych w mięśniowej fazie włośnicy. Wiadomości Parazytologiczne, 33, 509-515.
• Kasaian M. T., Brion C. A. 1990. Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus. Journal of Immunology, 144, 299-306.
• Kozar Z., Kozar M. 1972. Diagnostyka chorób pasożytniczych człowieka. PZWL, Warszawa.
• Lane Petter W., Pearson A. E. G. 1971. The laboratory animal - principles and practice. Academic Press, London-New York.
• Leiro J., Santamarina M. T., Sernandez L., Sanmartin M. L., Ubeira F. M. 1989. The effect of cyclosporine A on murine trichinellosis. Parasitology Research, 75, 330-332.
• McKenna R. M., Rush D. N.. Bakkestad-Legare P., Jeffery J. R. 1988. Interleukin 2, interferon, and lymphotoxin in renal transplant recipients. Transplantation, 45, 76-81.
• Metzger J. M., Peterson L. B. 1988. Cyclosporin A enhance the pulmonary granuloma response induced by Schistosoma mansoni eggs. Immunopharmacology, 15, 103-116.
• Nilsson L. A., Lindblad R., Olling S., Ouchterlony O.1985. The effect of cyclosporine A on the course of murine infection by Schistosoma mansoni. Parasite Immunology, 7, 19-27.
• Pearce E. J., Caspar P., Grzych J. M., Lewis F. A., Sher A. 1992. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. Journal of Experimental Medicine, 173, 159-166.
• Pereira G.M., Miller J. F., Shevach E. M. 1990. Mechanism of action of cyclosporine A in vivo. II T cell priming in vivo to alloantigen can be mediated by an IL-2-independent cyclosporine A - resistant pathway. Journal of Immunology, 144, 2109-2116.
• Thomson A. W., Smith S. W. G., Chappell L. H. 1986. Cyclosporine A: immune suppressant and antiparasitic agent. Parasitology Today, 2, 288-290.