Wplyw karotenoidow na zdrowie czlowieka

• Autorzy: Szpetnar M , Pasternak K.
• Języki publikacji: PL

Abstrakty

PL

Carotenoids comprise a group of natural pigments, which commonly occur in plants con­sumed by human. Structurally these pigments are terpenoids derived from condensation of prenyl pyrophosphates. Carotenoids with cyclic ß-ionone end groups are precursors of vitamin A. Epidemiological studies have shown many associations between diets rich in carotenoids and a reduced risk of different forms of cancer, cardiovascular diseases and increased action of immune system. However, at higher doses or under certain con­dition of the organism may exert toxic prooxidant activities of these compounds.

EN

Karotenoidy obejmują grupę naturalnych barwników, występujących powszechnie w ro­ślinach spożywanych przez ludzi. Strukturalnie są terpenoidami pochodzącymi z kon­densacji grupy prenylowej z pirofosforanami. Karotenoidy z pierścieniem b-jonowym na jednym ze swoich końców są prekursorami witaminy A. Badania epidemiologiczne wyka­zały wiele związków między dietą bogatą w karotenoidy a zmniejszeniem ryzyka róż­nych nowotworów, chorób sercowo-naczyniowych i polepszeniem funkcjonowania sys­temu odpornościowego. Jednak ich wysokie dawki w połączeniu z obniżoną kondycją organizmu mogą powodować prooksydacyjną aktywność tych związków.

Słowa kluczowe

PL

nowotwory; zdrowie czlowieka; promieniowanie ultrafioletowe; barwniki naturalne; uklad odpornosciowy; barwniki roslinne; choroby serca; karotenoidy; oddzialywanie na czlowieka

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2003
• Tom: 49
• Numer: 3-4
• Opis fizyczny: s.427-436,bibliogr.

Twórcy

autor

Szpetnar M

• Alademia Medyczna, ul.Staszica 4, 20-081 Lublin

autor

Pasternak K.

Bibliografia

• 1. SANDMANN G.: Genetic manipulation of carotenoid biosynthesis: strategies, problems and achievements. Trends Plant Sei. 2001, 6, 14.
• 2. GIULIANO G., AQUIUANI R., SRIDHAR D.: Metabolic engineering of plant carotenoids. Trends Plant Sei. 2000, 5, 406.
• 3. VAN HET HOF K.H., BROUWER I.A., WEST C.E. i wsp.: Bioavailability of lutein, from vegetable five times higher than that of ß-carotene. Am. J. Clin. Nutr. 1999, 70, 261.
• 4. OLSON J.A., HAYAISHI 0.: The enzimatic cleavage of ß-karotene into vitamin A by soluble en­zymes of rat liver and intestine. Natl. Acad. Sei. USA 1965, 54, 1364.
• 5. HANDELMAN G.: The evolving role of carotenoids in human biochemistry. Nutrition 2001, 17, 818.
• 6. BARNA A.B., OLSON J.A.: ß-Carotene is converted primarily to retinoids in rats in vivo. J. Nutr. 2000, 130, 1996.
• 7. TORBERGSEN A.C., COLLINS A.R.: Recovery of human lymphocytes from oxidative DNA dama­ge; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant efTect. Eur. J. Nutr. 2000, 39, 80.
• 8. MURATA T., TAMAI H., MORINOBU T. i wsp.: EfTect of long-term administration of beta-carote­ne on lymphocyte subsets in humans. Am. J. Clin. Nutr. 1994, 60, 597.
• 9. SANTOS M.S., LEKA L.S., RIBAYA-MERCADO J.D. i wsp.: Natural killer cell activity in elderly men isenhanced by beta-carotene supplementation. Am. J. Clin. Nutr. 1996, 64, 772.
• 10. BURRI B.J.: Carotenoids and gene expression. Nutrition 2000, 16, 577.
• 11. BURRI B.J.: Retinoids and the cancer prevention: crossing the line between food and drug. Nu­trition 2000, 16, 1100.
• 12. ME HTA P.P., BERTRAM J.S, LOWENSTEIN W.R.: Growth inhibition of transformed cells córrelates with their junctional communication and singlet oxygen quenching. Carcinogenesis 1991, 12, 671.
• 14. LOTAN R.: Lung cancer promotion by ß-carotene and tobacco smoke: relationship to suppression of retinoic acid receptor-ß and increased activator protein-l.J. Natl. Cancer Inst. 1999, 91, 7.
• 15. WANG X.D., LIU C., BRONSON R.T. i wsp.: Retinoid signaling and activator protein-1 expression in ferrets given ß-carotene supplements and exposed to tobacco smoke. J. Natl. Cancer Inst. 1999, 91, 60.
• 16. BJELKE E.: Dietary vitamin A and human lung cancer. Int. J. Cane. 1975, 15, 561.
• 17. NOMURA A.M., STEMMERMANN C.N., HEILBURN L.K. i wsp.: Serum vitamin levels and the risk of cancer of specific sites in men of Japanese ancestry in Hawaii. Cancer Res. 1985, 45, 2369.
• 18. LEE I.M., COOK N.R., MANSONJ.E. i wsp.: Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J. Natl. Cancer Inst. 1999. 91, 2102.
• 19. THE ALPHA-TOCOPHEROL beta carotene cancer prevention study group: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 1994, 330, 1029.
• 20. ALBANES D„ HE1NONEN O.P., HUTTUNEN J.K. i wsp.: Effect of alpha-tocopherol and beta-caro- tene supplements on cancer incidence in the alpha-tocopherol, beta-carotene cancer preven­tion study. Am. J. Clin. Nutr. 1995, 62, 1427S.
• 21. ROHAN T.E., JAIN M„ HOWE G.R., MILLER A.B.: A cohort study of dietary carotenoids and lung cancer risk in women (Canada). Cancer Causes. Control. 2002, 155, 622.
• 22. ALBERTINI R„ MORATTI R., DE LUCA G.: Oxidation of low-density lipoprotein in atherosclero­sis from basic biochemistry to clinical studies. Curr. Mol. Med. 2002, 2, 579.
• 23. OMENN G.S., GOODMAN G.E., TRONQUIST M.D. i wsp.: EfTects of a combination of beta caro­tene and vitamin A on lung cancer and cardiovascular disease. N. Engl. Med. 1996, 334, 1150.
• 24. BAKER D.L, KROL E.S., JACOBSON N., LIEBLER D.C.: Reactions of beta-carotene with cigarette smoke oxidants. Identification of carotenoid oxidation products and evaluation of the prooxi- dant/antioxidant effect. Chem. Res. Toxicol. 1999, 12, 535.
• 25. PALOZZA P., CALVIELLO G., BARTOLI G.M.: Reactions of beta-carotene with cigarette smoke oxidants. Identification of carotenoid oxidation products and evaluation of the prooxidant/an- tioxidant effect. Free. Rad. Biol. Med. 1995, 19, 887.
• 26. HOLICK C.N., MICHAUD D.S., STOLZENBERG-SOLOMON R. i wsp.: Dietary carotenoids, serum beta-carotene, and retino! and risk of lung cancer in the alpha-tocopherol, beta-carotene co­hort study. Am. J. Epidemiol. 2002, 156, 536.
• 27. GIOVANNUCC1 E.: Tomatoes, tomato-based products, lycopene, and cancer: review of the epi­demiologic literature. J. Natl. Cancer Inst. 1999, 91, 317.
• 28. LINDSEY H.: Consuming tomato products may reduce prostate-cancer risk. Lancet Oncol. 2002, 3: 198.
• 29. MILLER E.C., GIOVANNUCCI E„ ERDMAN J.W.JR i wsp.: Tomato products, lycopene, and pro­state cancer risk. Urol. Clin. North Am. 2002, 29, 83.
• 30. VOGTT.M., MAYNE S.T., GRAUBARD B.l. i wsp.: Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. Am. J. Epidemiol. 2002, 155, 1023.
• 31. HE1NONEN O.P., ALBANES D„ VIRTAMO J. i wsp.: Prostate cancer and supplementation with al­pha-tocopherol and beta-carotene: incidence and morality in a controlled trial. J Natl. Cancer. Inst. 1998, 90, 440.
• 32. STAHL W., SIES H.: Carotenoids and protection against solar UV radiation. Pharmacol. Appl. Skin. Physiol. 2002, 15, 291.
• 33. FULLER C.J., FAULKNER H„ BENDICH A. i wsp.: Effect of beta-carotene supplementation on photosuppresion of delayed-type hypersensitivity in normal young men. Am. J. Clin. Nutr. 1992, 56, 684.
• 34. HERRAIZ L.A., HSIEH W.C., PARKER R.S. i wsp.: Effect of UV exposure and beta-carotene sup-
• plementation on delayed-type hypersensitivity response in healthy older men. J. Am. Coll. Nutr. 1998, 17, 617
• 35. KROMHOUT D.: Diet and cardiovascular diseases. Nutr. Health Aging. 2001, 5, 144.
• 36. MARCHIOLI R., SCHWEIGER C., LEVANTESI G. i wsp.: Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data. Lipids 2001, 36 Suppl, 53.
• 37. KLIPSTEN G., GROBUSCH K., LAUNER L.J. i wsp.: Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis 2000, 148, 49.
• 38. RAO A.V.: Lycopene, tomatoes and the prevention of coronary heart disease. Exp. Biol. Med. 2002, 227, 908.
• 39. RISSANEN T., KOUT1LAINEN S., NYYSSONEN K„ SALONEN J.T.: Lycopene, atherosclerosis, and coronary heart disease. Exp. Biol. Med. 2002, 227, 900.
• 40. EICHHOLZER M., STAHELIN H.B., GEY K.P.: Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respec­tively: 12-year follow-up of the Prospective Basel Study. EXS. 1992, 62, 398. '9
• 41. FUKAO A., TSUBONO Y., KAWAMURA M. i wsp: The independent association of smoking and drinking with serum beta-carotene levels among males in Miyagi, Japan. Int. Epidemiol. 1996, 25, 300.
• 42. S1NGHAL S., GUPTA R., GOYLE A.: Comparision of antioxidant efficaly of vitamin E, vitamin C, vitamin A and fruits in coronary heart disease: a controlled trial. J. Assoc. Physicans. India 2001, 49, 327.
• 43. CHOPRA M., O'NEILL M.E., KEOGH N. i wsp.: Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. Clin. Chem. 2000, 46, 1818.
• 44. AGARWAL S., RAO A.V.: Tomato lycopene and low density lipoprotein oxidation: a human die­tary intervention study. Lipids 1998, 33, 981.
• 45. DUGAS T.R., MOREL D.W., HARRISON E.H.: Dietary supplementation with ß-carotene but not with lycopene, inhibits endothelial cell-mediated oxidation of low-density lipoprotein. Free Radie. Biol. Med. 1999, 26, 1238.
• 46. CARROLL Y.L., CORR1DAN B.M., MORRISSEY P.A.: Lipoprotein carotenoid profiles and the su­sceptibility of low density lipoprotein to oxidative modification in healthy elderly volunteers. Eur. J. Clin. Nutr. 2000, 54, 500.
• 47. BRAMELY P.M.: Regulation of carotenoid formation during tomato fruit ripening and deve­lopment. J. Exp. Bot. 2002, 53, 2107.