Cd2plus-promoted mitochondrial permeability transition: a comparison with other heavy metals

• Autorzy: Belyaeva E. A. , Glazunov V.V. , Korotkov S.M.
• Języki publikacji: EN

Abstrakty

EN

We compared action of Cd2+, Hg2+, and Cu2+ on isolated rat liver mitochondria in the absence of added Ca2+ and Pi. The heavy-metal ions produced dose-dependently: (1) enhanced membrane permeabilizaton manifested in mitochondrial swelling and activation of basal respiration, (2) inhibition of uncoupler-stimulated respiration, and (3) membrane potential dissipation. Among the metals, Cu2+ exhibited maximal stimulatory effect on basal respiration and minimal inhibitory action on DNP-uncoupled respiration whilst Cd2+ promoted the strongest depression of uncoupled respiration and the largest swelling in NH4NO3 medium. Dithiothreitol induced a basal respiration release if added after high [Cd2+] and [Hg2+], and the stimulation was CsA-insensitive.

Słowa kluczowe

EN

mercury; mitochondrion; respiratory chain; cadmium; copper; metal ion; cytotoxicity; mitochondrial permeability transition; heavy metal

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 2
• Opis fizyczny: p.545-551,fig.,ref.

Twórcy

autor

Belyaeva E. A.

• Russian Academy of Sciences, Thorez pr.44, 194223, St.Petersburg, Russia

autor

Glazunov V.V.

autor

Korotkov S.M.

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