Rola estrogenow w regulacji funkcji ukladu rozrodczego knura

• Autorzy: Zdunczyk S , Janowski T.

Warianty tytułu

EN

Role of oestrogens in the regulation of reproductive tract functions in the boar

• Języki publikacji: PL

Abstrakty

EN

This review article deals with the current knowledge on the role of oestrogens in the regulation of reproductive tract functions in the boar. Boars exhibit high amounts of oestrogens in blood plasma and semen. The predominant oestrogen is the conjugate and free oestrone. Oestrogens are synthesized in the boar only by Leydig cells, but not by Sertoli cells and germ cells. Oestrogen receptors are expressed in the testis (Leydig cells, Sertoli cells, peritubular myoid cells, and germ cells) and the epidydymis. These hormones influence the development and function of the reproductive tract and play an important role in the regulation of spermatogenesis. Environmental oestrogens, particularly mycotoxin zearalenone, may cause reproductive disturbances in boars. Seminal oestrogens seem to influence reproductive functions in the female pig, such as sperm transport in the genital tract and the occurrence of ovulation. Further investigations are needed to clarify the role of oestrogens in the reproductive tract of the boar.

Słowa kluczowe

PL

trzoda chlewna; knury; rozrod zwierzat; uklad rozrodczy; regulacja; estrogeny; funkcje biologiczne; stezenie hormonow

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2009
• Tom: 65
• Numer: 08
• Opis fizyczny: s.521-525,tab.,bibliogr.

Twórcy

autor

Zdunczyk S

• Uniwersytet Warminsko-Mazurski w Olsztynie, ul.Oczapowskiego 14, 10-178 Olsztyn

autor

Janowski T.

Bibliografia

• 1.At-Taras E. E., Berger T., McCarthy M. J., Conley A. J., Nitta-Oda B. J., Roser J. F.: Reducing estrogen synthesis in developing boars increases testis size and total sperm production. J. Androl. 2006, 27, 552-559.
• 2.At-Taras E. E., Conley A. J., Berger T., Roser J. F.: Reducing estrogen synthesis does not affect gonadotropin secretion in the developing boar. Biol. Reprod. 2006, 74, 58-66.
• 3.Attardi B. J., Pham T. C., Radler L. M., Burgenson J., Hild S. A., Reel J. R.: Dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-dimethyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase. J. Steroid Biochem. Molec. Biol. 2008, 110, 214-222.
• 4.Benzoni E., Minervini F., Giannoccaro A., Fornelli F., Vigo D., Visconti A.: Influence of in vitro exposure to mycotoxin zearalenone and its derivates on swine sperm quality. Reprod. Toxicol. 2008, 25, 461-467.
• 5.Berger T., McCarthy M., Pearl C. A., At-Taras E., Roser J. F., Conley A.: Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production and postpuberal boars. Anim. Reprod. Sci. 2008, 109, 218-235.
• 6.Booth W. D.: A study of some major testicular steroids in the pig in relation to their effect on the development of male characteristics in the prepubertally castrated boar. J. Reprod. Fertil. 1980, 59, 155-162.
• 7.Booth W. D.: Development of some male characteristics supported by oestrone but not dehydroepiandrosterone in the boar. J. Reprod. Fert. 1983, 68, 9-16.
• 8.Booth W. D.: In vitro metabolism of unconjugated androgens, oestrogens and the sulphate conjugates of androgens and oestrone by accessory sex organ of the mature domestic boar. J. Endocrinol. 1983, 96, 457-464.
• 9.Claus R.: Physiological role of seminal components in the reproductive tract of the female pig. J. Reprod. Fertil. 1990, Suppl. 40, 117-131.
• 10.Claus R., Hoffmann B.: Oestrogens, compared to other steroids of testicular origin in blood plasma of boars. Acta Endocrinol. 1980, 94, 404-411.
• 11.Claus R., Schopper D., Hoang-Vu C.: Contribution of individual compartments of the genital tract to oestrogen and testosterone concentrations in ejaculates of the boar. Acta Endocrinol. 1985, 109, 281-288.
• 12.Claus R., Schopper D., Wagner H. G.: Seasonal effect on steroids in blood plasma and seminal plasma of boars. J. Steroid Biochem. 1983, 19, 725-729.
• 13.Conley A. J., Corbin C. J., Hinshelwood M., Liu Z., Simpson E. R., Ford J. J., Harada N.: Functional aromatase expression in porcine adrenal glands and testis. Biol. Reprod. 1996, 54, 497-505.
• 14.Diekman M. A., Green M. L.: Myctoxins and reproduction in domestic livestock. J. Anim. Sci. 1992, 70, 1615-1627.
• 15.Elsaesser F., Parvizi N., Ellendorff F.: Steroid feedback on luteinizing hormone secretion during sexual maturation in the pig. J. Endocrinol. 1978, 78, 329-342.
• 16.Ford J. J.: Serum estrogen concentrations during postnatal development in male pigs. Proceed. Soci. Exp. Biol. Med. 1983, 174, 160-164.
• 17.Frączek B., Kotula-Balak M., Wojtusik A., Pierściński A., Bilińska B.: Cytochrome P450 in the testis of immature and mature boar testis. Reprod. Biol. 2000, 1, 51-59.
• 18.Hess R. A., Bunick D., Bahr J.: Oestrogen, its receptors and function in the male reproductive tract - a review. Mol. Cell. Endocrinol. 2001, 178, 29-38.
• 19.Lamanna C., Assisi L., Botte V., Di Fiore M. M.: Involvement of D-Asp in P450 aromatase activity and estrogen receptors in boar testis. Amino Acids 2007, 32, 45-51.
• 20.Lekhota O., Brehm R., Claus R., Wagner A., Bohle R. M., Bergmann M.: Cellular localization of estrogen receptor-alpha (ERα) and estrogen receptor beta (ERβ) mRNA in the boar testis. Histochem. Cell Biol. 2005, 25, 1-6.
• 21.Ljungvall K., Veeramachaneni D. N. R., Hou M., Hultén F., Magnusson U.: Morphology and morphometry of the reproductive organs in prepubertal and postpubertal male pigs exposed to di(2-ethylhexyl) phtalate before puberty: Precocious development of bulbourethral glands. Theriogenology 2008, 70, 984-991.
• 22.Lubbers L. S., Hileman S. M., Kuehl D. E., Ferreira S. A., Jackson G. L.: Temporal effects of estradiol (E) on luteinizing hormone on luteinizing hormone-releasing hormone (LHRH) on LH release in castrated male sheep. Dom. Anim. Endocrinol. 1998, 15, 511-524.
• 23.Luconi M., Forti G., Baldi E.: Genomic and nongenomic effects of estrogens: Molecular mechanisms of action and clinical implications for male reproduction. J. Steroid Biochem. Molec. Biol. 2002, 80, 369-381.
• 24.Mariscal D. V., Wolfe P. L., Bergfeldt E. G., Cupp A. S., Kojima F. N., Fike K. E., Sánchez T., Wehrman M. E., Johnson R. K., Kittok R. J., Ford J. J., Kinder J. E.: Comparison of circulating concentrations of reproductive hormones in boars of lines selected for size of testes or number of ovulations and embryonal survival to concentrations in respective control lines. J. Anim. Sci. 1996, 74, 1905-1914.
• 25.McCarthy M. J., Pearl Ch. A., At-Taras E. E., Nitta-Oda B. J., Roser J. F., Conley A. J., Berger T.: Suppression of endogenous estrogen during development affects porcine epididymial sperm maturation. Mol. Reprod. Dev. 2006, 73, 1122-1128.
• 26.Mutembei H. M., Pesch S., Schuler G., Hoffmann B.: Expression of oestrogen receptors α and β and of aromatase in the testis of immature and mature boars. Reprod. Dom. Anim. 2005, 40, 228-236.
• 27.Opałka M., Kamińska B., Dusza L.: Oddziaływanie fitoestrogenów na oś regulacyjną podwzgórze-przysadka-gonady u samców ssaków. Medycyna Wet. 2008, 64, 142-144.
• 28.Paziewska A., Biliñska B.: Estrogeny i ich rola w regulacji spermatogenezy. Postępy Biologii Komórki 2003, 30, 461-481.
• 29.Pearl Ch. A., At-Taras E. E., Conley A. J., Berger T., Roser J. F.: Estrogen and androgen receptor expression in relation to steroid concentrations in the adult boar epididymis. Dom. Anim. Endocrinol. 2007, 33, 451-459.
• 30.Pearl Ch. A., At-Taras E. E., Conley A. J., Berger T., Roser J. F.: Reduced endogenous estrogen delays epididymal development but has no effect on efferent duct morphology in boars. Reproduction 2007, 134, 593-604.
• 31.Pearl Ch. A., Roser J. F.: Expression of lactoferrin in the boar epididymis: Effects of reduced estrogen. Dom. Anim. Endocrinol. 2008, 34, 153-159.
• 32.Raeside J. I., Christie H. L., Renaud R. L.: Androgen and estrogen metabolism in the reproductive tract and accessory sex glands of the domestic boar (Sus scrofa). Biol. Reprod. 1999, 61, 1242-1248.
• 33.Raeside J. I., Renaud R. L.: Estrogen and androgen production by purified Leydig cells of mature boars. Biol. Reprod. 1983, 28, 727-733.
• 34.Raeside J. I., Renaud R. L, Friendship R. M.: Aromatization of 19-norandrogens by porcine Leydig cells. J. Steroid Biochem. 1989, 32, 729-735.
• 35.Raeside J. I., Renaud R. L., Friendship R. M.: Differences in aromatase activity between Leydig cells from the scrotal and abdominal testis in the naturally unilateral-cryptorchid boar. Biology of Reprod. 1988, 39, 566-572.
• 36.Raeside J. I., Wilkinson C. R., Farkas G.: Ontogenesis of estrogen secretion by porcine fetal testes. Acta Endocrinol. 1993, 128, 549-554.
• 37.Rago V., Maggiolini M., Vivacqua A., Palma A., Carpino A.: Differential expression of estrogen receptors (ERá/ERâ) in testis of mature and immature pigs. Anatomical Record – Part A 2004, 281, 1234-1239.
• 38.Ramesh R., Pearl C. A., At-Taras E., Roser J. F., Berger T.: Ontogeny of androgen and estrogen receptor expression in porcine testis: Effect of reducing testicular estrogen synthesis. Anim. Reprod. Sci. 2007, 102, 286-299.
• 39.Rostalski A., Hoffmann B., Riesenbeck A., Schuler G.: Investigations on the testicular production of free and conjugated oestrogens in the boar. Andrologia 2000, 32, 193.
• 40.Schinckel A. P., Johnson R. K., Kittok R. J.: Relationships among measures of testicular development and endocrine function in boars. J. Anim. Sci. 1984, 58, 1255-1261.
• 41.Schwarzenberger F., Toole G. S., Chrstie H. L., Raeside J. I.: Plasma level of several androgens and estrogens from birth to puberty in male domestic pigs. Acta Endocrinol. 1993, 128, 173-177.
• 42.Stein T., Ball B., Conley A., Bhatnagar A., Roser J.: The effects of an aromatase inhibiotor (Letrozole) on hormone and sperm production in the stallion. Theriogenology 2002, 58, 381-383.
• 43.Strzeżek J.: Wybrane aspekty poznawcze i aplikacyjne fizjologii reprodukcyjnej knura, [w:] Strzeżek J. (red.): Biologia rozrodu zwierząt. Biologiczne uwarunkowania wartości rozwodowej samca. Wyd. UWM w Olsztynie 2007, 159-201.
• 44.Terman A., Kmieć M., Polasik D.: Estrogen receptor gene (ESR) and semen characteristics of boars. Arch. Tierzucht 2006, 49, 71-76.
• 45.Waberski D., Soares J. A. G., Bandeira de Arruda E., Weitze K.: Effects of transcervical infusion of seminal plasma prior to insemination on the fertilizing competence of low numbers of boar spermatozoa at controlled AI-ovulation intervals. Anim. Reprod. Sci. 1996, 44, 165-173.
• 46.Wagner A., Messe N., Bergmann M., Lekhota O., Claus R.: Effects of estradiol infusion in GnRH immunized boars on spermatogenesis. J. Androl. 2006, 27, 880-889.
• 47.Weiler U., Claus R.: Endocrine aspects of testicular function, especially hormones in the seminal plasma and their fate in the female reproductive tract: testicular steroids and their relevance for male and reproductive functions. Reprod. Dom. Anim. 1991, Suppl. 1, 41-61.
• 48.Willmen T., Rabeler L., Everwand A., Waberski D., Weitze K. F.: Influence of seminal plasma and oestrogens in the inseminate on fertilization rate, sperm transport and ovulation time. Reprod. Dom. Anim., Suppl. 1: 379-383.
• 49.Winter P., Nau H., Lampen A., Kamphues J.: Detection of estrogenically active substances in diets for sows by an in vitro bioassay supported by HPLC analysis. J. Anim. Physiol. Anim. Nutr. 2008, 92, 337-344.
• 50.Zamaratskaia G., Rydhmer L., Chen G., Andersson H. K., Lundström K.: Boar taint is related to endocrine and anatomical changes at puberty but not to aggressive behaviour in entire male pigs. Reprod. Dom. Anim. 2005, 40, 500-506.