Expression and activity of superoxide dismutase isoenzymes in colorectal cancer

• Autorzy: Skrzycki M. , Majewska M. , Podsiad M. , Czeczot H.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was an evaluation of changes in protein level and activity of SOD isoenzymes, and the participation of AP-1 and NF-κB in subsequent stages of colorectal cancer development. Studies were conducted on 65 colorectal cancers. Controls were unchanged colon regions. Activity of SOD isoenzymes, lipid peroxidation level (TBARS), and protein level of SOD1, SOD2, AP-1 and NF-κB were determined. We found that the protein level and activity of SOD isoenzymes and protein level of AP-1 and NF-κB change in subsequent stages of clinical advancement of colorectal cancer, according to UICC (I-IV), and in grades of tumor cells differentiation (G1-G3). These results indicate adaptation of colorectal cancer cells to oxidative stress, and show that the observed changes of SOD activity and protein level depend on gradual progression of colorectal cancer, and suggest an impairment of processes regulated by AP-1 and NF-κB which are critical for tumor progression (proliferation, differentiation and apoptosis).

Słowa kluczowe

EN

ulcerative colitis; meat; reactive oxygen species; diet; smoking; Polish population; risk factor; colon inflammatory disease; hereditary genetic predisposition; colorectal cancer; age; superoxide dismutase; fat; transcription factor; colorectal adenocarcinoma; mortality

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2009
• Tom: 56
• Numer: 4
• Opis fizyczny: p.663-670,fig.,ref.

Twórcy

autor

Skrzycki M.

• Warsaw Medical University, St.Banacha 1, 02-097 Warsaw, Poland

autor

Majewska M.

autor

Podsiad M.

autor

Czeczot H.

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