Antifungal activity of thionated analogues of Nva-FMDP and Lys-Nva-FMDP

• Autorzy: Nowak-Jary J , Andruszkiewicz R.
• Języki publikacji: EN

Abstrakty

EN

The antifungal activity of synthetic endothiopeptdides, i.e. NvaΨ [CSNH]-FMDP and LysΨ [CSNH]-NvaΨ [CSNH]-FMDP was studied in medium containing blood serum, against selected Candida strains; Candida albicans Gu4 (fluconazole sensitive), C. albicans Gu5 (fluconazole resistant), C. albicans ATCC 10231, Candida krusei DSM 6128 and Candidaparapsilosis DSM 5784. Although thiopeptide bonds in the tested peptides increased their stability in blood serum, their antifungal activity, however, drastically decreased in comparison with the peptides containing non-modified peptide bonds. Moreover, the inhibitory activity towards glucosamine-6-phosphate synthase of thionated synthetic analogue of FMDP was performed. The thiopeptdide bond also influenced its inhibitory properties against enzyme from C. albicans.

Słowa kluczowe

EN

Candida krusei; Candida albicans; glucosamine-6-phosphate synthase inhibitor; antifungal activity; antifungal compound; thiopeptide; synthetic endiothiopeptide; peptide cleavage; peptide; Candida parapsilosis; endothiopeptide

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2009
• Tom: 58
• Numer: 4
• Opis fizyczny: p.295-299,fig.,ref.

Twórcy

autor

Nowak-Jary J

• Gdansk University of Technology, Narutowicza Street 11/12, 80-952 Gdansk, Poland

autor

Andruszkiewicz R.

Bibliografia

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