Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems

• Autorzy: Zielenkiewicz U. , Ceglowski P.
• Języki publikacji: EN

Abstrakty

EN

The stable inheritance of bacterial plasmids is achieved by a number of different mechanisms. Among them are resolution of plasmid oligomers into monomers, active plasmid partitioning into dividing cells and selective killing of plasmid-free segre- gants. A special focus is given to the last mechanism. It involves a stable toxin and an unstable antidote. The antidotes neutralize their cognate toxins or prevent their syn­thesis. The different decay rates of the toxins and the antidotes underlie molecular mechanisms of toxin activation in plasmid-free cells. By eliminating of plasmid-free cells from the population of plasmid-bearing ones the toxin-antidote couples therefore act as plasmid addiction systems.

Słowa kluczowe

EN

chromosome; cell; partition; post-segregational killing; plasmid; plasmid addiction; multimer resolution

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1003-1023,fig.

Twórcy

autor

Zielenkiewicz U.

• Polish Academy of Sciences, A.Pawinskiego 5a, 02-106 Warsaw, Poland

autor

Ceglowski P.

Bibliografia

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