Protective effect of pantothenic acid and related compounds against permeabilization of Ehrlich ascites tumour cells by digitonin

• Autorzy: Slyshenkov V. S. , Rakowska M. , Wojtczak L.
• Języki publikacji: EN

Abstrakty

EN

Preincubation of Ehrlich ascites tumour cells with millimolar concentrations of pantothenic acid, pantothenol or pantethine, but not with homopantothenic acid, at 22°C or 32°C, but not at 0°C, makes the plasma membrane more resistant to the damaging effect of submillimoiar concentrations of digitonin. It is proposed that this increased resistance is due to the increased rate of cholesterol biosynthesis. In fact, incorporation of [14C]acetate into cholesterol is by 45% increased in the cells preincubated with pantothenic acid; this probably reflects elevation of the content of CoA in such cells [Slyshenkov, V.S., Rakowska, M., Moiseenok, A.G. & Wojtczak, L. (1995) Free Radical Biol. Med. 19,767-772].

Słowa kluczowe

EN

Ehrlich ascites tumour; plasma membrane; cholesterol biosynthesis; pantothenic acid; digitonin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 2
• Opis fizyczny: p.407-410,fig.

Twórcy

autor

Slyshenkov V. S.

• M.Nencki Institute of Experimental Biology, L.Pasteura 3, 02-093 Warsaw, Poland

autor

Rakowska M.

autor

Wojtczak L.

Bibliografia

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