Bifunctional inhibitors of protein kinases for intracellular applications

• Autorzy: Uri A , Viht K. , Pooga M.
• Języki publikacji: EN

Słowa kluczowe

EN

drug market; pharmaceutical company; intracellular application; drug target; bifunctional inhibitor; protein kinase

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 2A
• Opis fizyczny: p.564-565

Twórcy

autor

Uri A

• University of Tartu, Tartu, Estonia

autor

Viht K.

autor

Pooga M.

Bibliografia

• 1.Cohen, P. Protein kinases - the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 1 (2002) 309-315.
• 2.Parang, K. and Cole P.A. Designing bisubstrate analog inhibitors for protein kinases Pharmacol. Ther. 93 (2002) 145-157.
• 3.Loog, M., Uri, A., Raidaru, G., Jarv, J. and Ek, P. Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg. Med. Chem. Lett. 9,(1999) 1447-1452.
• 4.Shugar, D. The NTP phosphate donor in kinase reactions: is ATP a monopolist? Acta Biochim. Pol. 43 (1996) 9-23.
• 5.Uri, A., Raidaru, G., Subbi, J., Padari, K. and Pooga, M. Identification of the ability of highly charged nanomolar inhibitors of protein kinases to cross plasma membranes and carry a protein into cells. Bioorg. Med. Chem. Lett. 12 (2002) 2117-2120.