Effect of prenatal cadmium and ethanol exposure on the duration of ethanol - induced sleep in female and male rats

• Autorzy: Szkilnik R. , Felinska W. , Brus R.
• Języki publikacji: EN

Abstrakty

EN

Female adult Wistar rats were given tap warter (control), 10% (v/v) water solution of ethanol and/or cadmium (5 or 50 ppm) in tap water or in 10% ethanol ad libitum throughout their pregnacies. As soon as the offspring were born, the administration of all above solutions was discontinued and all females began drinking water only. Adult female and male offspring from each group were challenged with a single hypnotic dose of ethanol (3.5 g/kg IP) in the form of 20% (v/v) water solution. The latency from the time of injection until the loss of the righting reflex, as well as the latency for recovery of the reflex was recorded. The results showed that female rats exposed to cadmium after ethanol 3.5 g/kg IP challenge lose the righting reflex rapidly and recovery of it was later as compared to control animals. In female rats exposed during intrauteral development to cadmium jointly with ethanol measured parameters return to values as in the control group. No statistically significant differences in loss and recovery of the righting reflex in all groups of male rats after the ethanol 3.5 g/kg IP challenge was recorded.

Słowa kluczowe

EN

Wistar rat; ethanol; prenatal exposure; male; cadmium; righting reflex; rat; female

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1994
• Tom: 03
• Numer: 3
• Opis fizyczny: p.25-28,ref.

Twórcy

autor

Szkilnik R.

• Silesian Academy of Medicine, H.Jordana 38, 41-808 Zabrze, Poland

autor

Felinska W.

autor

Brus R.

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