Farmakokinetyka oraz utrzymywanie sie fenbendazolu i jego metabolitow w mleku

• Autorzy: Szprengier-Juszkiewicz T , Jankuszew W. , Semeniuk S.
• Języki publikacji: PL

Abstrakty

EN

Ten lactating healthy cows received single oral doses of Fenbesan (7,6 mg kg⁻¹ b.w. of fenbendazole). Blood samples were collected at 0, 2, 4, 8, 12, 24, 36, 48, 60, 72, 84, 96, 108 and 120 h. Milk samples were taken twice daily from day 0 to 6 after drug administration. Fenbendazole (FBZ), oxfendazole (OXZ) and FBZ sulfone were analysed by HPLC with UV detection. The detection limit was 0,01 µg ml⁻¹ of FBZ and 0,005 µg ml⁻¹ of OXZ and FBZ-sulfone. The highest residues of FBZ, expressed as the sum of parent drug and metabolites were found after 24 and 36 h levels of 0,077 ± 0,01 µg ml⁻¹ and 0,114 ± 0,03 µg ml⁻¹ in milk and plasma respectively. The data show that the parent drug was present in measured quantities in plasma samples collected 8, 12 and 24 h after drug administration (Cmax 0,028 ± 0,008 µg ml⁻¹, Tmax 17,6 ± 0,4 h). In milk, FBZ was detected only 24 h after treatment (0,014 ± 0,006 µg ml⁻¹). This proves that metabolites (OXZ and FBZ-sulfone) dominate in milk and plasma residues. The total residues of FBZ in milk and plasma were below the detection limit by day 5 following a single oral administration of the drug.

Słowa kluczowe

PL

pozostalosci lekow weterynaryjnych; krew; bydlo; farmakokinetyka; leki przeciwpasozytnicze; mleko; zwalczanie pasozytow zwierzat; metabolity; fenbendazol; okres karencji

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 1998
• Tom: 54
• Numer: 12
• Opis fizyczny: s.833-837,rys.,tab.,bibliogr.

Twórcy

autor

Szprengier-Juszkiewicz T

• Panstwowy Instytut Weterynaryjny, Al.Partyzantow 57, 24-100 Pulawy

autor

Jankuszew W.

autor

Semeniuk S.

Bibliografia

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