Selectin glycoprotein ligands

• Autorzy: Zak I. , Lewandowska E. , Gnyp W.
• Języki publikacji: EN

Abstrakty

EN

Lectin selectins and their counter-receptors participate in discontinuous cell-cell interactions concurrent with leukocyte tethering and rolling on endothelium, which, in consequence, leads to leukocyte penetration to lymphatic organs and generation of inflammation sites. Counter-receptors are glycoproteins in which carbohydrate units, the direct selectin ligands, are built into the polypeptide framework. In this review, the distribution, structure and function of the main ligands and counter-receptors for P-, L- and E-selectins known so far, have been discussed. The common biosynthetic pathway of sialyl-Lewis x and sulpho-sialyl-Lewis x determinants of selectin ligands has been described.

Słowa kluczowe

EN

sulpho-sialyl Lewis[x] determinant; sialyl-Lewis[x] determinant; ligand; glycoprotein; cell-cell interaction; lymphatic organ; endothelium; leucocyte; selectin ligand

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 2
• Opis fizyczny: p.393-412,fig.

Twórcy

autor

Zak I.

• Silesian Medical Academy, Katowice, Poland

autor

Lewandowska E.

autor

Gnyp W.

Bibliografia

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