Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures

• Autorzy: Zalewska A. , Brzoska M.M. , Marciniak J. , Karaszewska K. , Zwierz K. , Moniuszko-Jakoniuk J.
• Języki publikacji: EN

Abstrakty

EN

Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "envi­ronmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of ß-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, ß-N-acetylhexosa- minidase showed the highest activity. The activities of a-mannosidase and ß-galacto- sidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.

Słowa kluczowe

EN

glycoprotein; alpha-mannosidase; exoglycosidase; beta-N-acetylhexosaminidase; tooth; submandibular gland; salivary gland; rat; beta-galactosidase; occupational exposure; proteoglycan; man; oral mucosa; cadmium; cigarette smoking; glycolipid; toxic metal

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 3
• Opis fizyczny: p.831-837,fig.,ref.

Twórcy

autor

Zalewska A.

• Medical University of Bialystok, Adama Mickiewicza 2a, 15-222 Bialystok, Poland

autor

Brzoska M.M.

autor

Marciniak J.

autor

Karaszewska K.

autor

Zwierz K.

autor

Moniuszko-Jakoniuk J.

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