PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 54 | 2 |

Tytuł artykułu

Copper content in neoplastic and healthy mammary glands in dogs

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the investigation was to confirm the hypothesis put forward in human research that copper is cumulated in the neoplastic tumours of the mammary gland. The research material included the post mortem collected healthy mammary glands of bitches and mammary gland neoplastic tumours obtained during routine surgical treatments. The histopathological examinations revealed that among tumours of epithelial origin, the most frequent were adenocarcinomas, which comprised 64% of all neoplastic lesions. The second group included carcinomas - 26%, whereas 10% were the tumours of mesenchymal origin. The lowest copper content was observed in healthy mammary glands. In the tissues with neoplastic lesions, the content of copper was at a much higher level. Statistical analysis revealed a significant difference (P≤0.05) in the copper content between the investigated groups. The performed analyses showed that mammary gland neoplasms cumulate copper ions, and a much higher concentration of this element is observed in the tumours of epithelial origin.

Wydawca

-

Rocznik

Tom

54

Numer

2

Opis fizyczny

p.269-272,fig.,ref.

Twórcy

  • Warsaw University of Life Sciences - SGGW, 02-786 Warsaw, Poland
autor

Bibliografia

  • 1. Brewer G.J.: Copper lowering therapy with tetrathiomolybdate as an antiangiogenic strategy in cancer. Curr Cancer Drug Targets 2005, 5, 195-202.
  • 2. Branson R.T.: Variation in age at death of dogs of different sexes and breeds. Am J Vet Res 1982, 43, 2057-2059.
  • 3. Cadieu E., Ostrander E.A.: Canine genetics offers new mechanisms for the study of human cancer. Cancer Epidemiol Biomarkers Prev, 2007, 16, 2181-2183.
  • 4. Carvahlo M.L., Magalhães T., Becker M., von Bohlen A.: Trace elements in human cancerous and healthy tissues: a comparative study by EDXRF, TXRF, synchrotron radiation and PIXE. Spec Acta 2007, 62, 1004-1011.
  • 5. Cunzhi H., Jiexian J., Xianwen Z., Jingang G., Shumin Z., Lili D.: Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervival cancer and uterine myoma. Biol Trace Elem Res 2003, 94, 113-122.
  • 6. Dincer Z., Jasani B., Haywood S., Mullins J.E., Fuentealba I.C.: Metallothionein expression in canine and feline mammary and melanotic tumors. J Comp Path 2001, 125, 130-136.
  • 7. Egenvall A., Bonett B.N., Ohagen P., Olson P., Hedhammar A., von Euler H.: Incidence of and survival after mammary tumors in a population of over 80,000 insured female dogs in Sweden from 1995 to 2002. Prev Vet Med 2005, 69, 109-127.
  • 8. Finney L., Vogt S., Fukai T., Glesne D.: Copper and angiogenesis: unraveling a relationship key to cancer progression. Clin Exp Pharm Phys 2009, 36, 88-94.
  • 9. Floriańczyk B., Grzybowska L.: Concentration of metallothionein and microelements in breast cancer. Polish J Environ Stud 2006, 15, 69-71.
  • 10. Hermo G.A., Torres P., Ripoll G.V., Scursoni A.M., Gomez D.E., Alonso D.F., Gobello C.: Perioperative desmopressin prolongs survival in surgically treated bitches with mammary gland tumors: a pilot study. Vet J 2007, 178, 103-108.
  • 11. Kent M.S., Madewell B.R., Dank G., Dick R., Merajver S.D., Brewer J.: An anticopper antiangiogenic approach for advanced cancer in spontaneously occurring tumors using tetrathiomolybdate: a pilot study in a canine animal model. J Trace Elem Exp Med 2004, 17, 9-20.
  • 12. Kubala-Kukuś A., Banaś D., Braziewicz J., Góźdź S., Majewska U., Pajek M.: Analysis of elemental concentration censored distribution in breast malignant and breast benign neoplasm tissues. Spec Acta 2007, 62, 695-701.
  • 13. Lowndes S.A., Harris A.L.: The role of copper in tumor angiogenesis. J Mammary Gland Biol Neoplasia 2005, 10, 299-310.
  • 14. Magalhaes T., Becker M., Carvalho M.L., von Bohlen A.: Study of Br, Zn, Cu and Fe concentration in healthy and cancer breast tissues by TXRF. Spec Acta 2008, 63, 1473-1479.
  • 15. Mandigers P.J.J., Bode P., van Wees A.M.T.C., van den Brom W.E., van den Ingh T.S.G.A.M., Rothuizen J.: Hepatic 64 Cu excretion in Dobermanns with subclinical hepatitis. Res Vet Sci 2007, 83, 204-209.
  • 16. Naga-Raju G.J., Sarita P., Ravi-Kumar M., Ramana- Murty G.A.V., Reddy B.S., Lakshminarayana S., Vijayan V., Rama-Lakshmi P.V.B., Gavarasana S., Bhuloka-Reddy S.: Trace element correlation study in malignant and normal breast tissue by PIXE technique. Nucl Inst Meth Phys Res 2006, 247, 361-367.
  • 17. Nasulewicz A., Mazur A., Opolski A.: Role of copper in tumor angiogenesis-clinical implications. J Trace Element in Med Biol 2004, 18. 1-8.
  • 18. Ostrander E.A., Wayne R.K.: The canine genome. Genom Res 2005, 15, 1706-1716.
  • 19. Schneider R.: Comparison of age, sex, and incidence rates in human and canine breast cancer. Cancer 1970, 26, 419-426.
  • 20. Semela D., Dufour J.F.: Angiogenesis and hepatocellular carcinoma. J Hepatol 2004, 41, 864-880.
  • 21. Siddiqui M.K.J., Jyoti S.S., Mehrotra P.K., Singh K., Sarangi R.: Comparison of some trace element concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study. Environ Intern 2006, 32, 630- 637.
  • 22. Tapiero H., Townsend D.M., Tew K.D.: Trace elements in human physiology and pathology. Copper. Biomed Pharmacother 2003, 57, 386-398.
  • 23. Vail D.M., McEwen E.G.: Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest 2000, 18, 781-792.
  • 24. Wąsowicz W., Gromadzińska J.: Potential role of selected antioxidants and trace elements in cancer development. Żyw Człow Metab 2005, 32, 34-41.
  • 25. Zatloukal J., Lorenzova J., Tichy F., Nečas A., Kecova H., Kohout P.: Breed and age as risk factors for canine mammary tumours. Acta Vet Brno 2005, 74, 103-109.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-e4188264-2c25-4949-a042-be7b0fb717b5
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.