Multiple drug resistance in Candida albicans

• Autorzy: Prasad R. , Murthy S.K. , Gupta V. , Prasad R.
• Języki publikacji: EN

Abstrakty

EN

By functional complementation of a PDR 5 (pleiotropic drug resistance) null mutant of S. cerevisiae, we have recently cloned and sequenced a multidrug resistance gene CDR1 (Candida Drug Resistance). Transformation by CDR1 of a PDR 5 disrupted host hypersensitive to cycloheximide and chloramphenicol resulted in resistance to these as well as other unrelated drugs. The nucleotide sequence of CDR 1 revealed that, like PDR 5, it encodes a putative membrane pump belonging to the ABC superfamily. CDR 1 encodes a protein of 169.9 kDa whose predicted structural organisation is characte­rised by two homologous halves, each comprising a hydrophobic region, with a set of six transmembrane stretches, preceded by a hydrophilic binding fold. We now have evidence to suggest that there are several PDR homologues present in C. albicans which display multidrug resistance and a collateral sensitivity pattern different from PDR 5 and CDR 1. The functions of such genes and their products in the overall physiology of C. albicans is not yet established.

Słowa kluczowe

EN

pleiotrophic drug resistance; human pathogen; Candida albicans; multiple drug resistance; Saccharomyces cerevisiae

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 4
• Opis fizyczny: p.497-504,fig.

Twórcy

autor

Prasad R.

• Jawaharlal Nehru University, New Delhi-110067, India

autor

Murthy S.K.

autor

Gupta V.

autor

Prasad R.

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