Binding of the basic fibroblast growth factor [bFGF] by soluble components of human umbilical cord

• Autorzy: Sobolewski K. , Bankowski E. , Palka J. , Jaworski S.
• Języki publikacji: EN

Abstrakty

EN

Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the umbilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an important role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic new­borns demonstrated that both the umbilical cord arterial wall and Wharton's jelly con­tain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associated with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF re­leased from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulating them to produce collagen and sulphated glycosaminoglycans.

Słowa kluczowe

EN

insulin-like growth factor; cell growth; glycosaminoglycan; man; Wharton's jelly; cord tissue; umbilical cord artery; growth factor; fibroblast

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 4
• Opis fizyczny: p.999-1004,fig.

Twórcy

autor

Sobolewski K.

• Medical Academy of Bialystok, A.Mickiewicza 2, 15-230 Bialystok, Poland

autor

Bankowski E.

autor

Palka J.

autor

Jaworski S.

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