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2000 | 46 | 1 |

Tytuł artykułu

Efficacy of mebendazole in treatment of selected parasitoses - a retrospective study

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The efficacy of mebendazole was evaluated as a result of six-year experience in the treatment of patients of Outpatients Clinic and Clinic of Infectious, Parasitic and Tropical Diseases in Łódź. The treatment covered 6132 subjects infected with: Ascaris lumbricoides, Ancylostoma duodenale, Trichiuris trichiura, Enterobius vermicularis and Echinococcus granulosus. Nematode infections were diagnosed by coproscopic methods whereas echinococcosis with serologie tests and ultrasonographic examination of abdominal cavity. Mebendazole was administered in the dose of 200 mg per day: for 3 days in ascariasis, for 5 days in A. duodenale, T. trichiura and mixed infections. In enterobiosis was applied a pulsation therapy: 200 mg a day for 3 days, a week of break (three subsequent cycles). In echinococcosis the drug was administered in the daily dose of 600 mg for 30 days. Follow-up examinations were carried out 30, 60, 120 and 160 days after the treatment. In the case of inetfectiveness of the first course, the treatment was repeated. The efficacy of the therapy was as follows: ascariasis 97.1%, A. duodenale infection 100%, trichuriasis 92.1%, enterobiosis 93.3%, mixed infections 95.3%, echinococcosis 77.2%. No side effects were observed.

Wydawca

-

Rocznik

Tom

46

Numer

1

Opis fizyczny

p.127-139,fig.,ref.

Twórcy

autor
  • The Dr Wl.Bieganski Voivodeship Specialist Hospital, Kniaziewicza 1-5, 91-347 Lodz, Poland
autor

Bibliografia

  • ALBONICO M., RENGANATHAN E., BOSMAN A., KISUMBU U. M., ALAWI K. S., SAVIOLI L. 1994 a. Efficacy of a single dose of mebendazole on prevalence and intensity of soil-transmitted nematodes in Zanzibar. Trop. Geogr. Med. 46: 142-146.
  • ALBONICO M., SMITH P. G., HALL A., CHWAYA H. M., ALAWI K. S., SAVIOLI L. 1994 b. A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris and hookworm infections. Trans. R .. Soc. Trop. Med. Hyg. 88: 585-589.
  • BARTOLONI A., GUGUELMETTI P., CANCRINI G., GAMBOA H., R0SELLI M., NIC0LETTI A.et al. 1993. Comparative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections in children. Trop. Geogr. Med. 45: 114-116.
  • CHANG J. H., HUANG W. H., CHEN E. R., HU S. C. 1995. Results of school children with eneterobiasis in Tainan city, treated with mebendazole. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih. 11: 27-38.
  • CHRUŚCIEL T., GIBIŃSKI K. 1992. Anthelmintica In: Leksykon Leków [Drugs' Lexicon] 1st edn. PZWL, Warszawa [Warsaw, Poland] pp. 276-279.
  • DRUSCHKY K. F., NIEDERSTADT T., J0URDAN W., STOLTZE D., HECKL R. 1995. Hochgradiges Querschnittsyndrom durch Echinokkuszysten. Nervenarzt 66: 136-139.
  • ERSAHIN Y., MUTLUER S., GUZELBAG E. 1993. Intracranial hydatid cysts in children. Neurosurgery 33:219-225.
  • GOCMEN A., T0PPARE M. F., KIPER N. 1993. Treatment of hydatid disease in childhood with mebendazole. Eur. Respir. J. 6: 253-257.
  • JONGSUKSUNTIGUL P., JERADIT C., P0RNPATTANAKUL S., CHARANASRI u. 1993. A comparative study of the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis. Southeast. Asian. J. Trop. Med. Public. Health. 24: 724-729.
  • PAWŁOWSKI Z. 1996. Robaczyce tkankowe (Tissue helminthiasis) In: Choroby zakaźne i pasożytnicze (Parasitic and infectious diseases). 1st edn (ed. Z. Dziubek), PZWL, Warszawa (Warsaw, Poland), pp. 293 -304.
  • PETRI A., KARACSONYI S., KALMAR N. K., LEINDLER L. 1993. Surgical management of liver echinococcosis. Orv. Hetil. 134: 1465-1468.
  • PIWOWARCZYK K., KAMIŃSKA E., KARWAŃSKI M. et al. 1995. Leki (Drugs) In: Pharmindex Kompendium. 1st edn. (ed. K. Piwowarczyk) MediMedia International, Warszawa (Warsaw, Poland) pp. 53-638 (Mebendazol pp. 537-538).
  • RENGANATHAN E., ERCOLE E., ALBONICO M. et al. 1995. Evolution of operational research studies and development of a national control strategy against intestinal helminths in Pemba Island, 1988-1992. Bull. World Health Organ. 73:183-190.
  • ROUSHAM E. K., MASCIE-TA YLOR C. G. 1994. An 18-month study of the effect of periodic anthelminthic treatment on the growth and nutritional status of pre-school children in Bangladesh. Ann. Hum. Biol. 21: 315-324.
  • SINHA P. R., JAIPURIA N., AVASTHEY P. 1995. lntracardiac hydatid cyst and sudden death in a child. Int. J. Cardiol. 51: 293-295.
  • TEGGI A., LASTILLA M. G., DE ROSA F. 1993. Therapy of human hydatid disease with mebendazole and albendazole. Antimicrob. Agents Chemother. 37: 1679-1684.
  • WIRBEL R. J., MUES P. E., MUTSCHLER W. E., SALOMON-LOOIJEN M. 1995. Hydatid disease of the pelvis and the femur. A case report. Acta Orthop. Scand. 66: 440-442.
  • XIAO S., FENG J ., Y AO M. 1995. Effect of antihydatid drugs on carbohydrate metabolism of metacestode of Echinococcus granulosus. Chin. Med. J Engl. 108: 682-688.

Typ dokumentu

Bibliografia

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Identyfikator YADDA

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