Effect of long-term cadmium intoxication on selected biochemical parameters in experimental animals

• Autorzy: Kowalczyk E , Jankowski A. , Niedworok J. , Smigielski J. , Tyslerowicz P.
• Języki publikacji: EN

Abstrakty

EN

Cadmium (Cd) is a dangerous occupational and environmental toxin. Exceeding its permissible weekly uptake in meals is a disturbing phenomenon. The aim of this study is to assess the effect of long-term uptake of cadmium chloride on selected biochemical parameters and oxidative stress biomarkers in animal models. Long-term intoxication with cadmium chloride elevated blood serum concentration of urea, creatinine, glucose, AspAT and AlAT activity as well as TBARS and protein carbonyl group concentrations; TBARS concentration in erythrocytes was also elevated as well as 8-hydroxy-2’-deoxyguanosine excretion with urine.

Słowa kluczowe

EN

human activity; environmental toxin; occupational toxin; economic activity; oxidative stress; animal; cadmium; experimental animal; intoxication; biochemical parameter; heavy metal

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2002
• Tom: 11
• Numer: 5
• Opis fizyczny: p.599-601

Twórcy

autor

Kowalczyk E

• Military Medical University in Lodz, Plac Hallera 1, 90-647 Lodz, Poland

autor

Jankowski A.

autor

Niedworok J.

autor

Smigielski J.

autor

Tyslerowicz P.

Bibliografia

• 1. KLOS A. Lead, cadmium and mercury content in meals planned for consumption in selected kindergartens in War saw. IV International Scientific - Technical Conference Warsaw 4-5 X 2001.
• 2. BARROUILLET M.P., MOIRET A., CAMBAR J. Protective effects of polyphenols against cadmium - induced glomerular mesangial cell myocontracture. Arch. Toxicol. 8-9 (73) 485, 1999.
• 3. CAI Y.Q, TERANISHI H., AOSHIMA K., KATOH T., ARAI Y., KASUYA N. Development of the fluorometric ELISA method for determination of alpha (1) - micro- globulinuria in a cadmium - polluted area in Japan. Int. Arch. Occup. Environ. Health 7 (74), 514, 2001.
• 4. LIU J., LIU Y.P., HABEEBU S.M., WAALKES M.P., KLAASSEN CD. Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein I/II null mice. Toxicology 147, 157, 2000.
• 5. SHAIKH Z.A., VU T.T., ZAMAN K. Oxidative stress as a mechanism of chronic cadmium- induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol. Appl. Pharmacol. 154 (3), 256, 1999.
• 6. STOHS S.J., BAGCHI D., HASSOUN E., BAGCHI M. Oxidative mechanisms in the toxicity of chromium and cadmiumions. J. Environ.Pathol. Toxicol. Oncol. 20 (2), 77, 2001.
• 7. RICE-EVANS C.A., DIPLOCK A.T., SYMONS M.C.R. Techniques in free radicals. In: Biological basis of detoxication. Ed: Caldwell J., Jacoby W.B.: Acad. Press, New York - Toronto pp 181-211, 1983.
• 8. LEVINE R.L., GARLAND D, OLIVER C.N., AMICI A., CLIMENT J..LENZ A., AHN B.M., SHALTEIL S., STA- DTMAN E.R. Determination of carbonyl content of oxidatively modified proteins. Methods. Enzymol. 186, 464, 1990.
• 9. REZNIK A. Z., PACKER L. Oxidative damage to proteins: Spectrophotometric method for carbonyl assay. Methods. Enzymol. 233, 357, 1994.
• 10. NGUYEN Q.H., CHIEN P.K. Cadmium uptake kinetics in human erythrocytes. Biol. Trace. Elem. Res. 22, 119, 1989.
• 11. THEOCHARIS S.E., MARGELI A.P, VASSILIKI A., VARONOS D. Thimidyne kinase activity in liver and serum of rats after cadmium administration. Toxicol. Lett. 71, 1, 1994.
• 12. URIU K., KAIZU K., QIE Y.L., ITO A., TAKAGI I., SUZUKA K., INADA Y., HASHIMOTO O, ETO S. Long term oral intake of low dose cadmium exacerbates age related impairment of renal functional reserve in rats. Toxi col. Appl. Pharmacol. 169, 151, 2000.
• 13. YIIN S.J, CHERN C.L., SHEU J.Y., TSENG W.C., LIN T.H. Cadmium induced renal lipid peroxidation in rats and protection by selenium. J. Toxicol. Environ. Health. 57 (6), 403, 1999.
• 14. RIKANS L.E., YAMANO T. Mechanisms of cadmium mediated acute hepatotoxicity. J. Biochem. 14,110, 2000.
• 15. ZIKIC R.V., STAJN A.S., PAVLOVIC S.Z., OG- NJANOVIC B.I., SAICI Z.S. Activities of superoxide dismutase and catalase in erythrocytes and plasma transaminases of goldfish (Carassius auratus gibelio Bloch) exposed to cadmium. Physiol. Res. 50 (1), 105, 2001.
• 16. CASALINO E, CALZARETTI G., SBLANO C, LAND­RISCINA C. Cadmium - dependent enzyme activity alteration is not imputable to lipid peroxidation. Arch. Biochem. Biophys. 383 (2), 288, 2001.
• 17. POURAHMAD J, BRIEN O. Contrasting role of Na(+) ions in modulating Cu(+2) or Cd(+2) induced hepatocyte toxicity. Chem. Biol. Interact. 126 (2), 159, 2000.
• 18. LOPEZ- ORTAL P., SOUZA V., BUCIO L, GOZALEA E., GUTIERREZ RUIZ M.C. DNA damage produced by cadmium in human fetal hepatic cell line. Mutat. Res. 19, 301, 1999.
• 19. MOURON S.A., GOLIJOW CD, DULOUT F.N. DNA damage by cadmium and arsenic salts assessed by the single ell gel electrophoresis assay. Mutat. Res. 498, 47, 2001.
• 20. CERDA S, WEITZMAN S.A. Influence of oxygen radical injury on DNA methylation. Mutat. Res. 386 (2), 141, 1997.
• 21. JOSEPH P, MUCHNOK T.K, KLISHIS M.L., ROBERTS JR., ANTONINI J.M, WHONG W.Z, ONG T.M. Cadmium induced cell transformation and tumorogenesis are asociated with transcriptional activation of c-fos, c-jun, and c-myc protooncogenes. Role of cellular calcium and reactive oxygen species. Toxicol. Sci. 61, 295, 2001.
• 22. SAPLAKOGLU U, ISCAN M, ISCAN M. DNA single strand breakage in rat lung, liver and kidney after single and combined treatments of nickel and cadmium. Mutat. Res. 394 (1-3), 133, 1997.