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2007 | 51 | 3 |

Tytuł artykułu

Influence of tamoxifen on sexual impulse and semen biological values in male dogs

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The study was conducted on 12 male dogs (5 to 10 years of age). The animals were divided into 2 groups: the experimental one (6 tamoxifen-treated dogs) and the control one (6 clinically healthy dogs). Besides, a clinical examination evaluating the overall state of health and sexual impulse, the examination of testosterone level in the blood serum was performed as well as the examination of semen (spermatozoa concentration, percentage of dead spermatozoa, evaluation of spermatozoa morphology, and evaluation of spermatozoa cell membrane activity - HOS test). It was found that tamoxifen had a negative influence on the function of the reproductive system in the dogs and caused, already in the first week of the treatment, the worsening of most of the evaluated characteristics of the semen and later, after the second week of the treatment, it produced aspermia with the complete loss of male fertility. The loss of fertility turned out to be periodical and lasted for about 60 d. After that time, the dogs regained the ability to produce ejaculate, though of much weakened quality, but later it was gradually improving.

Wydawca

-

Rocznik

Tom

51

Numer

3

Opis fizyczny

p.383-391,fig.,ref.

Twórcy

autor
  • Agricultural University in Lublin, 20-612 Lublin, Poland
autor
autor
autor

Bibliografia

  • 1. Anapliton M., Evagellon E., Kostanies I., Iparaki M., Prasa P., Goulandris N.: Effect of cotreatment with human chorionic gonadotropin in testicular steroidogenesis and seminal insulin-like growth factor-1 in oligozoospermia. Fertil Steril 1996, 66, 305-311.
  • 2. Arnesen K., Gamlem H., Glattre E., Moe L., Nordstoga K.: Registration of canine cancer. Tidsskr Nor Laegeroren 1995, 28, 714-717.
  • 3. Blom E.: Morfological assessment of sperm defects in a bull. Proposal of the new sperm defect classification. Medycyna Wet 1981, 37, 239-242.
  • 4. Bowen R. H., Olson P.N., Young S., Wihrow S.J.: Efficacy and toxicity of tamoxifen citrate for prevention and termination of pregnancy in bitches. Am J Res 1998, 49, 27-31.
  • 5. Bramswig J.H., Heimes U., Heiermann E., Schlegel W., Niesche E., Schellong G.: The effects of different cumulative doses of chemotherapy on testicular function. Results in 75 patients treated for Hodgkin's disease during childhood or adolescence. Cancer 1990, 65, 1298- 1302.
  • 6. Breier B., Vickers M., Gravance C., Casey P.: Growth hormone therapy markedly increases the motility of spermatozoa and the concentration of insulin-like growth factor - I in seminal vesicle fluid in the male dwarf rat. Endocrinology 1996, 137, 4061-4064.
  • 7. Doshi M.B., Derashri H.J., Mehta V.M., Kodagali S.B.: Effects of clomiphene on blood testosterone and quality of ejaculates in bulls. Indian vet J 1994, 71, 246-249.
  • 8. Dubiel A.: Fizjologia i anatomia narządów rozrodczych psa. Magazyn Wet 1997, 6, 336-339.
  • 9. Dynarowicz I.: Chemioterapia chorób nowotworowych zwierząt. I Konferencja Naukowa Onkologia weterynaryjna, postępy w diagnostyce i terapii. Olsztyn, 1997, pp. 69-77.
  • 10. England G.C.W.: Effect of progestagens and androgens upon spermatogenesis and steroidogenesis in dogs. Theriogenology 1997, 51, 123-138.
  • 11. England G.C.W.: Rozród i położnictwo psów według Allena. Ed. SIMA WLW, Warszawa, 1998.
  • 12. Feldman E.C., Nelson R.W.: Canine and feline endocrinology and reproduction. WB Sanders Co, Philadelphia, 1996.
  • 13. Gill-Shaema M.K., D'Souza S., Parte P., Balasinor N., Choudhuri J., Majramkar D.D., Aleem M., Juneja H.S.: Effect of oral tamoxifen on semen characteristics and serum hormone profile in male bonnet monkeys. Contraception 2003, 67, 409-413.
  • 14. Glander H.J., Kratzsch J., Weisbrich C., Brikenmeyer G.: Insulin growth factor-I and α₂-macroglobulin in seminal plasma correlate with semen quality. Hum Reprod 1996, 11, 2454-2460.
  • 15. Gopalkrishnan K., Gill-Sharma M.K., Balasinor N., Padwal V., D'Souza S., Parte P., Jayaraman S., Juneja H.S.: Tamoxifen-induced light and electron microscopic changes in the rat testicular morphology and serum hormonal profile of reproductive hormones. Contraception 1998, 57, 261-269.
  • 16. Howell S.J., Radford J.A., Ryder W.D., Shalet S.M.: Testicular function after cytotoxic chemotherapy, evidence of Leydig cell insufficiency. J Clin Oncol 1999, 17, 1493-1498.
  • 17. Johnston S.D.: Performing a complete canine semen evaluation in small animal hospital. Vet Clin N Am Small Animal 1991, 21, 545-551.
  • 18. Kawakami E., Amemiya E., Namikawa K., Kashiwagi Ch., Hori T., Tsutsui T.: High plasma estradiol - 17ß levels in dogs with benign prostatic hyperplasia and azoospermia. J Vet Med Sci 2001, 63, 407-412.
  • 19. Kawakami E., Hori T., Tsutsui T.: Changes in plasma testosterone and testicular transferrin concentration, testicular histology and semen quality after treatment of Testosterone-Depot plus PMSG to 3 dogs with astenozoospermia. J Vet Med Sci 2000, 62, 203-206.
  • 20. Kieza Z.: Chemioterapia onkologiczna w wybranych schorzeniach nowotworowych u psów. I Konferencja Onkologiczna. Wybrane zagadnienia z chorób nowotworowych psa i kota. Szczecin - Maciejowo, 2003, pp. 4-15.
  • 21. Kłaczyński W.: Effectiveness of tamoxifen - hexal in the treatment of neoplasms in dogs. Medycyna Wet 1998, 54, 281-283.
  • 22. Kotoulas J.G., Cardamakis E., Michopoulos J., Mitropoulos D., Dounis A.: Tamoxifen treatment in male infertility. Effect of spermatozoa. J Fert Steril 1994, 61, 45-49.
  • 23. Kula K., Sałata J.M., Słowikowska-Hilczer J.: Tamoksyfen a spermatogeneza u szczurów poddanych działaniu estrogenów. Ginecol Pol 2002, 65, 58-62.
  • 24. Lisowski M., Bednarczyk M., Kłosowska D., Elminowska - Wenda G., Maćkowiak P., Nogowski L., Nowak K.: Influence of tamoxifen on testosterone concentration in blood and on the development of cocks testis tissue. Medycyna Wet 2003, 59, 344-347.
  • 25. Machnik G., Lechniak D.: The impact of growth hormone (GH) on male reproduction. Medycyna Wet 2000, 56, 218-221.
  • 26. Malasa A., Faeolda R., Alagna S., Satta A., Chiarelli G., Rovasio P.P., Ivaldi R., Taras M.S., Lai E., Bartoli E.: Use of testosterone to prevent cyclophosphamide induced azoospermia. Ann Inter Med 1997, 15, 292-295.
  • 27. Malinowska A.: Biochemiczne podstawy neoplazji. VI. Najczęściej stosowane metody we współczesnej terapii antynowotworowej. Życie Wet 2002, 77, 81-86.
  • 28. Markowska J.: Chemioterapia nowotworów narządu rodnego. Nowa Medycyna 1998, 5, 28-31.
  • 29. Michalska Z., Michalski Z.: Prevalence of neoplasms in domestic animals in Wroclaw and Lower Silesia during 1976-1995. Medycyna Wet 1997, 53, 263-267.
  • 30. Orzechowska-Juzwenko K.: Zarys chemioterapii nowotworów narządowych i układowych. Volumed Wrocław. Wrocław, 2000.
  • 31. Pennisi A.J., Grushkin C.M., Lieberman E.: Gonadal function in children with nephrosis treated with cyclophosphamide. Am J Dis Child 1975, 129, 315-318.
  • 32. Sałata I. M., Słowikowska-Hilczer J., Kula K.: Wpływ dojądrowego podawania tamoksyfenu na spermatogenezę i wydzielanie testosteronu u szczura. Ginecol Pol 1994, 65, 63-66.
  • 33. Saratsis Ph., Ypsilantis P., Tselkos K.: Semen quality during vincristine treatment in dogs with transmissible venerai tumor. Theriogenology 2000, 53, 1185-1192.
  • 34. Senkus-Konefka E.:Hormonalne leczenie nowotworów. Stan obecny i perspektywy. Nowa Medycyna. Onkologia 2000, 5, 10-12.
  • 35. Sfikakis P.P., Kostomitsopoulos N., Kittas C., Stathopoulos J., Karayannacos P., Dellia-Sfıkakis A., Mitropoulos D.: Tamoxifen exerts testosterone-depended and independed effects on thymic involution. Inter J Immunopharmacol 1998, 20, 305-312.
  • 36. Taha M.B., Noakes D.E., Allen W.E.: The effect of season of the year on the characteristics and composition of dog semen. J Small Anim Prac 1981, 22, 663-667.
  • 37. Walter J.H., Schwegler K.: The frequency of neoplasms in dogs dissected in Berlin. Zentralbl Veterinarmed 1992, 39, 328-341.
  • 38. Wrona Z., Krakowski L., Łopuszyński W., Kostro K., Kowalski C., Brodzki P.: Evaluation of fertility and nonspecific cellular defence in male dogs after applying tamoxifen. Medycyna Wet 2003, 59, 1000-1004.
  • 39. Zduńczyk S., Janowski T.: Zaburzenia rozrodu psów i kotów. Ed. University of Warmia and Mazury. Olsztyn, 2002, p. 97

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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