Some aspects of oligoribonucleotides synthesis via the H-phosphonate approach

• Autorzy: Stawinski J. , Kraszewski A.
• Języki publikacji: EN

Abstrakty

EN

This review gives a short account of selected aspects of oligoribonucleotide synthesis via the H-phosphonate method. It includes: (i) recent methods for the preparation of suitably protected ribonucleoside 3'-H-phosphonates (the phosphonylation step), (ii) some chemical and stereochemical features of the formation of H-phosphonate internucleosidic linkages, and (iii) stereoselective synthesis of oligoribonucleoside phosphorothioates using chemo-enzymatic approach.

Słowa kluczowe

EN

RNA; stereoselective synthesis; H-phosphonate method; oligoribonucleotide synthesis; oligonucleotide analogue

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 4
• Opis fizyczny: p.907-915,fig.

Twórcy

autor

Stawinski J.

• Stockholm University, Stockholm, Sweden

autor

Kraszewski A.

Bibliografia

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