Mouse models of experimental atherosclerosis

• Autorzy: Jawien J. , Nastalek P. , Korbut R.
• Języki publikacji: EN

Abstrakty

EN

Since 1992 the mouse has become an excellent model for experimental atherosclerosis research. Until 1992, the diet - induced atherosclerosis mouse model has been used effectively, but the lesions tended to be small and were limited to early fatty-streak stage. This model was also criticized because of the toxicity and inflammatory responses due to the diet. In 1992 the first line of gene targeted animal models, namely apolipoprotein E - knockout mice was developed. Of the genetically engineered models, the apoE - deficient model is the only one that develops extensive atherosclerotic lesions on a chow diet. It is also the model in which the lesions have been characterized most thoroughly. The lesions develop into fibrous plaques; however, there is no evidence that plaque rupture occurs in this model. The LDL receptor - deficient model has elevated LDL levels, but no lesions, or only very small lesions, form on the chow diet, however, robust lesions do form on the western-type diet. The creation of apoE - knockout mice has changed the face of atherosclerosis research.

Słowa kluczowe

EN

triglyceride level; mouse; LDL receptor; lipoprotein; mice; knockout mouse; apoE-knockout mouse; cardiovascular disease; cholesterol; atherosclerosis; animal model

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 3
• Opis fizyczny: p.503-517,fig.,ref.

Twórcy

autor

Jawien J.

• Jagiellonian University School of Medicine, 16 Grzegorzecka Str., 31-531 Krakow, Poland

autor

Nastalek P.

autor

Korbut R.