The effect of quercetin, chlorogenic acid and epigallocatechin on proliferation of Caco-2 cells

• Autorzy: Duda-Chodak A. , Markiewicz D. , Pierzchalski P.

Warianty tytułu

PL

Wplyw kwercetyny, kwasu chlorogenowego i epigalokatechiny na proliferacje komorek Caco-2

• Języki publikacji: EN

Abstrakty

EN

Dietary polyphenols are considered beneficial because of their potential protective role in the pathogenesis of chronic diseases associated to oxidative stress. However, many of these effects may depend on the concentration of the antioxidants used. The aim of the study was to evaluate the effect of quercetin, chlorogenic acid and epigallocatechin on proliferation of human colon adenocarcinoma cells Caco-2. Caco-2 cells were treated with different concentrations (25, 50, 100, 200, and 400 μM in DMSO) of antioxidants and the proliferation was assayed by MTT method. The results of the study indicated that chlorogenic acid and quercetin enhanced Caco-2 cells proliferation in time- and concentration-dependent manner. In contrary, epigallocatechin exhibit inhibitory influence, particularly significant at concentration ≥ 200 μM.

PL

Polifenole zawarte w diecie uważa się za pożyteczne ze względu na ich potencjalnie ochronną rolę w patogenezie przewlekłych chorób wywołanych przez stres oksydacyjny. Jednakże, wiele z obserwowanych efektów może zależeć od stężenia użytych przeciwutleniaczy. Celem badań była ocena wpływu kwercetyny, kwasu chlorogenowego i epigalokatechiny na komórki Caco-2. Proliferację komórek Caco-2 poddanych działaniu różnych stężeń przeciwutleniaczy (25, 50, 100, 200 i 400 μM w DMSO) oceniano w teście z MTT. Wykazano, że kwas chlorogenowy i kwercetyna zwiększały proliferację komórek Caco-2 w stopniu zależnym od czasu i stężenia. Natomiast epigalokatechina wykazywała hamujący wpływ, szczególnie w stężeniu ≥ 200 μM.

• Wydawca: -
• Czasopismo: Acta Scientiarum Polonorum. Technologia Alimentaria
• Rocznik: 2009
• Tom: 08
• Numer: 1
• Opis fizyczny: p.63-69,fig.,ref.

Twórcy

autor

Duda-Chodak A.

• University of Agriculture in Krakow, Krakow, Poland

autor

Markiewicz D.

autor

Pierzchalski P.

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