Effects of pituitary adenylate cyclase-activating polypeptide [PACAP] on cyclic AMP formation in the duck and goose brain

• Autorzy: Nowak J Z , Kuba K. , Zawilska J.B.
• Języki publikacji: EN

Abstrakty

EN

Two molecular forms of pituitary adenylate cyclase-activating polypeptide (PACAP), i.e., PACAP27 and PACAP38 (0.0001-1 |jM), as well as vasoactive intestinal polypeptide (VIP; 0.1-3 |LiM), have been studied for their effects on cyclic AMP formation in the hypothalamus and cerebral cortex of duck and goose. All three peptides concentration-dependently stimulated cyclic AMP production in the tested brain regions of 2-3-weeks-old (young) ducks, with VIP showing at least one order of magnitude weaker activity than PACAP. This characteristics suggests the existence in the duck's brain of adenylyl cyclase-linked PACi receptors. Both forms of PACAP also stimulated the nucleotide formation in the cerebral cortex and hypothalamus of 5-6-months-old (adult) ducks or geese grown under natural environment. The peptides-evoked effects in adult and young ducks were comparable, and clearly greater than those found in adult geese. The present data extend our recent observations made on chicks, and suggest PACAP to be a potent stimulator of the cyclic AMP generation in the avian central nervous system.

Słowa kluczowe

EN

nucleotide formation; duck; hypothalamus; pituitary adenylate cyclase-activating polypeptide; brain; cerebral cortex; goose; vasoactive intestinal polypeptide; central nervous system

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2000
• Tom: 60
• Numer: 2
• Opis fizyczny: p.209-214,fig.

Twórcy

autor

Nowak J Z

• Polish Academy of Sciences, 3 Tylna St., P-225, 90-950 Lodz, Poland

autor

Kuba K.

autor

Zawilska J.B.

Bibliografia

• Basile M., Gonzalez B .J., Desrues L., Demas M., Fournier A., Vaudry H. (1995) Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts. J. Neurochem. 65: 1318-1324.
• Chartrel N., Tonon M.C., Vaudry H., Conlon J.M. (1991) Pri­mary structure of frog pituitary adenylate cyclase-activat­ing polypeptide (PACAP) and effects of ovine PACAP on frog pituitary. Endocrinology 129: 3367-3371.
• Christophe J. (1993) Type I receptors for PACAP (a neuro­peptide even more important than VIP?). Biochem. Bio- phys. Acta 1154: 183-199.
• Harmar A.J., Arimura A., Gozes I., Journot L., Laburthe M., Pisegna J.R., Rawlings S.R., Robberecht P., Said S.I., Sreedharan S.P., Wank S.A., Waschek J.A. (1998) Interna­tional Union of Pharmacology. XVIII. Nomenclature of re­ceptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol. Rev. 50: 265-270.
• McRory J., Parker D.B., Ngamvongchon S., Sherwood N.M. (1995) Sequence and expression of cDNA for pituitary adenylate cyclase-activating peptide (PACAP) and growth hormone-releasing hormone (GHRH)-like peptide in cat­fish. Mol. Cell. Endocrinol. 108: 169-177.
• Miyata A., Jiang L., Dahl R.D., Kitada C., Kubo K., Fujino M., Minamino N., Arimura A. (1990) Isolation of a neuropep­tide corresponding to the N-terminal 27 residues of the pi­tuitary adenylate cyclase activating polypeptide with 38 residues (PACAP38). Biochem. Biophys. Res. Commun. 170: 643-648.
• Nilsson S.F.E., Amer N., Vandermeers A. (1996) Adenylate cy­clase activation by VIP and PACAP in the retina and choroid: effects of antagonists. Ann. NY Acad. Sci. 805: 749-752.
• Nowak J.Z., Kuba K., Zawilska J.B. (1999a) PACAP-in- duced formation of cyclic AMP in the chicken brain: re­gional variations and the effect of melatonin. Brain Res. 830: 195-199.
• Nowak J.Z., Kuba K., Zawilska J.B. (1999b) Stimulatory ef­fect of pituitary adenylate cyclase-activating polypeptide (PACAP) on cyclic AMP formation in the hypothalamus and cerebral cortex of four avians and rat. Pol. J. Pharma­col. 51: 87-91.
• Nowak J.Z., Sek B. (1994) Stimulatory effect of histamine on cyclic AMP formation in chick pineal gland. J. Neurochem. 63: 1338-1345.
• Nowak J.Z., Sek B., D'Souza T., Dryer S.E. (1995) Does his­tamine stimulate cyclic AMP formation in the avian pineal gland via a novel (non-H 1, non-H2, non-H3) histamine re­ceptor subtype. Neurochem. Int. 27: 519-526.
• Onali P., Olianas M.C. (1994) PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the re­tinas of different mammalian species. Brain Res. 641: 132-134.
• Peeters K., Berghman L.R., Vandesande F. (1998a) Com­parative distribution of pituitary adenylate cyclase-activat­ing polypeptide and vasoactive intestinal polypeptide immunoreactivity in the chicken forebrain. Ann. NY Acad. Sci. 839:417-419.
• Peeters K., Gerets H.H.J., Princen K., Vandesande F. (1999) Molecular cloning and expression of a chicken pituitary adenylate cyclase-activating polypeptide receptor. Mol. Brain Res. 71: 244-255.
• Peeters K., Langouche L., Vandesande F., Darras V.M., Ber­ghman L.R. (1998b) Effects of pituitary adenylate cyclase- activating polypeptide (PACAP) on cAMP formation and growth hormone release from chicken anterior pituitary cells. Ann. NY Acad. Sci. 865: 471-474.
• Rawlings S.R., Hezareh M. (1996) Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/va- soactive intestinal polypeptide receptors: actions on the anterior pituitary gland. Endocrine Rev. 17: 4-29.
• Salomon Y., Londos C., Rodbell M. (1974) A highly sensitive adenylate cyclase assay. Anal. Biochem. 58: 541-548.
• Shimizu H., Daly J.W., Creveling C.R. (1969) A radioisotopic method for measuring the formation of adenosine 3' ,5 '-cy­clic monophosphate in incubated slices of brain. J. Neu­rochem. 16: 1609-1619.
• Wong A.O.L., Leung M.Y., Shea W.L.C., Tse L.Y., Chang J.P., Chow B.K.C. (1998) Hypophysiotropic action of pi­tuitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: immunohistochemical demonstration of PACAP in the pituitary, PACAP stimulation of growth hor­mone release from pituitary cells, and molecular cloning of pituitary type I PACAP receptor. Endocrinology 139: 3465-3479.
• Yon L., Feuilloley M., Chartrel N., Arimura A., Conlon J.M., Fournier A., Vaudry H. (1992) Immunohistochemical dis­tribution and biological activity of pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nervous system of the frog Rana ridibunda. J. Comp. Neu­rol. 324: 485-499.