S-nitrosoglutathione modulates CXCR4 and ICOS expression

• Autorzy: Yamamoto Y , Pahwa R. , Pahwa S.
• Języki publikacji: EN

Abstrakty

EN

The expression of CXCR4, a membrane protein which is involved in the entry of HIV-1, is down-modulated from the cell surface by Phorbol 12-myristate 13-acetate (PMA) and the Ca+ ionophore, Ionomycin. Inducible co-stimulator (ICOS), which contributes to lymphocyte proliferation, is up-regulated by PMA/Ionomycin. We examined the influence of S-nitrosoglutathione (SNG), an inhibitor of Vacuolar H+-ATPase (V-ATPase), on the expression of CXCR4 and ICOS in PMA/Ionomycin-treated peripheral mononuclear cells (PBMC), and of CXCR4 alone in lymphoid cell lines. In this report, we show that SNG interferes with both effects of PMA/Ionomycin, namely CXCR4 down-regulation and ICOS up-regulation. These studies imply opposing roles of V-ATPase in the regulation of CXCR4 and ICOS. The influence of SNG in modulating the susceptibility of T cells to HIV-1 and on their immune responses needs further investigation.

Słowa kluczowe

EN

inducible co-stimulator; membrane-associating protein; cell surface protein; intracellular protein transportation; S-nitrosoglutathione; expression

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2006
• Tom: 11
• Numer: 1
• Opis fizyczny: p.30-36,fig.,ref.

Twórcy

autor

Yamamoto Y

• New York University School of Medicine, 350 Community Drive, Manhasset, NY, 11030, USA

autor

Pahwa R.

autor

Pahwa S.

Bibliografia

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