Bradykinin-related peptides up-regulate the expression of kinin B1 and B2 receptor genes in human promonocytic cell line U937

• Autorzy: Guevara-Lora I. , Florkowska M. , Kozik A.
• Języki publikacji: EN

Abstrakty

EN

 Kinins, universal mediators of inflammation, are recognized by two kinds of receptors, B1 and B2, which have been found to be expressed in numerous cell types of several species. However, the knowledge of the regulation of these receptors in leukocytes is still not satisfactory. In the current work, we have demonstrated a constitutive production of B2 receptor mRNA in the human promonocyte U937 cells and its two-fold augmentation after cell differentiation with retinoic acid and phorbol ester. Bradykinin and des-Arg10-kallidin induced the expression of both B2 and B1 receptors in cells before and after differentiation. Generally, the undifferentiated cells were more susceptible to bradykinin-dependent induction of kinin receptors (increases by approximately 250% and 200% for B2 and B1 receptors, respectively). The induction, by approx. 200%, of B1 receptor by des-Arg10-kallidin was detected on both mRNA and protein levels. In addition, an unexpected strong induction of B2 receptor by this compound was observed in the retinoic acid- and phorbol ester-differentiated cells (by 150% and 200%, respectively) that suggests a possible autoregulation of kinin receptors by own agonists during the inflammatory state. On the other hand, a strong enhancement of the expression of both receptors by interleukin 1β, especially in the phor­bol ester-differentiated cells, indicates the involvement of kinin receptors in the propagation of the inflammatory processes.

Słowa kluczowe

PL

bradykinin-related peptide; kinin; B1 receptor; B2 receptor; gene; cell line; kinin receptor; macrophage; cytokine; inflammation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2009
• Tom: 56
• Numer: 3
• Opis fizyczny: p.515-522,fig.,ref.

Twórcy

autor

Guevara-Lora I.

• Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland

autor

Florkowska M.

autor

Kozik A.

Bibliografia

• Barbasz A, Guevara-Lora I, Rapala-Kozik M, Kozik A (2008) Kininogen binding to the surfaces of macrophages. Int Immunopharmacol 8: 211-216. 
• Bertram CM, Baltic S, Misso NL, Bhoola KD, Foster PS, Thompsom PJ, Fogel-Petrovic M (2007) Expression of kinin B1 and B2 receptors in immature monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration. J Leukoc Biol 81: 1445-1454. 
• Bhoola KD, Figueroa CD, Worthy K (1992) Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol Rev 44: 1-80. 
• Blais Ch Jr., Marceau F, Rouleau J-L, Adam A (2000) The kallikrein-kininogen-kinin system: lessons for the quantification of endogenous kinins. Peptides 21: 1903-1940. 
• Bockmann S, Mohrdieck K, Schmidt H, Zundorf G, Paegelow I (1992) Differential sensitivity of macrophages to bradykinin. Naunyn Schmiedebergs Arch Pharmacol 357: 151-158. 
• Bockmann S, Paegelow I (1995) Bradykinin receptors and signal transduction pathways in peritoneal guinea pig macrophages. Eur J Pharmacol 291: 159-165. 
• Böckmann S, Paegelow I (2000) Kinins and kinin receptors: importance for the activation of leukocytes. J Leukoc Biol 68: 587-592. 
• Calixto JB, Cabrini DA, Ferreira J, Campos MM (2000) Kinins in pain and inflammation. Pain 87: 1-5. 
• Cassim B, Mody G, Bhoola KD (2002) Kallikrein cascade and cytokines in inflamed joints. Pharmacol Ther 94: 1-34. 
• Cavender DE, Edelbaum D, Welkovich L (1991) Effects of inflammatory cytokines and phorbol esters on the adhesion of U937 cells, a human monocyte-like cell line, to endothelial cell monolayers and extracellular matrix proteins. J Leukoc Biol 49: 566-578. 
• Ehrenfeld P, Millan C, Matus CE (2006) Activation of kinin B1 receptors induces chemotaxis of human neutrophils. J Leukoc Biol 80: 117-124. 
• Haddad El-B, Fox AJ, Rousell J, Burgess G, Mcintyre P, Barnes PJ, Fan Chung K (2000) Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-α: modulation by dexamethasone. Mol Pharmacol 57: 1123-1131.  
• Hamada K, Utiyama K (2005) Functional cytoplasmic of the Mac-1 integrin receptor on phorbol ester-treated U937 cells. Biochem Biophys Res Commun 335: 858-864. 
• Harris P, Ralph P (1985) Human leukemic models of myelomonocytic development: a review of the HL-60 and U937 cell lines. J Leukoc Biol 37: 407-422. 
• Honma Y, Takenaga K, Kasukabe T, Hozumi M (1980) Induction of differentiation of cultured human promyelocytic leukemia cells by retinoids. Biochem Biophys Res Commun 95: 507-512. 
• Imamura T, Tanase S, Hayashi I, Potempa J, Kozik A, Travis J (2002) Release of a new vascular permeability enhancing peptide from kininogens by human neutrophil elastase. Biochem Biophys Res Commun 294: 423-428. 
• Joseph K, Kaplan AP (2005) Formation of bradykinin: a major contribution to the innate inflammatory response. Adv Immunol 86: 159-208. 
• Kozik A, Moore RB, Potempa J, Imamura T, Rapala-Kozik M, Travis J (1998) A novel mechanism for bradykinin production at inflammatory sites. Diverse effect of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens. J Biol Chem 273: 33224-33229.  
• Labudda O, Wierzba T, Sobolewski D, Sleszynska M, Gawinski Ł, Plackova M, Slaninova J, Prahl A (2007) New bradykinin analogues acylated on the N-terminus: effect on rat uterus and blood pressure. Acta Biochim Polon 54: 193-198. 
• Leeb-Lundberg LMF, Marceau F, Muller-Esterl W, Pettibone DJ, Zuraw BL (2005) International Union of Pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to the pathological consequences. Pharmacol Rev 57: 27-77. 
• Marceau F, Hess JF, Bachvarov DR (1998) The B1 receptors for kinins. Pharmacol Rev 50: 357-386. 
• Mathis SA, Criscimagna NL, Leeb-Lundberg LMF (1996) B1 and B2 kinin receptors mediate distinct patterns of intracellular Ca2+ signaling in single cultured vascular smooth muscle cells. Mol Pharmacol 50: 128-139. 
• McLean PG, Perretti M, Ahluwalia A (2000) Kinin B1 receptors and the cardiovascular system: regulation of expression and function. Cardiovasc Res 48: 194-210. 
• Pesquero JB, Lindsy CJ, Paiva ACM, Ganten D, Bader M (1996) Transcriptional regulatory elements in the rat bradykinin B2 receptor gene. Immunopharmacology 33: 36-41. 
• Phagoo SB, Poole S, Leeb-Lundberg LMF (1999) Autoregulation of bradykinin receptors: agonists in the presence of interleukin-1 beta shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts. Mol Pharmacol 56: 325-333. 
• Phagoo SB, Reddi K, Anderson KD, Leeb-Lundberg LMF, Warburton D (2001) Bradykinin B1 receptor up-regulation by interleukin-1β and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts. J Pharmacol Exp Ther 298: 77-85. 
• Rajasekariah P, Warlow RS, Wall RS (1997) High affinity bradykinin binding to human inflammatory cell. Biochem Mol Biol Int 43: 279-290. 
• Rutherford MS, Witsell A, Schook LB (1993) Mechanism generating functionally heterogeneous macrophages: chaos revisited. J Leukoc Biol 53: 602-618. 
• Schanstra JP, Bataille E, Castano MEM, Barascud Y, Hirtz C, Pesquero JB, Pecher C, Gauthier F, Girolami JP, Bascands JL (1998) The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous up-regulation of the bradykinin B1-receptor in cultured human lung fibroblasts. J Clin Invest 101: 2080-2091. 
• Tsukagoshi H, Shimizu Y, Horie T, Fukabori Y, Shimizu Y, Iwamae S, Hisada T, Ishizuka T, Iizuka K, Dobashi K, Mori M (1999) Regulation by interleukin-1β of gene expression of bradykinin B1 receptor in MH-S murine alveolar macrophage cell line. Biochem Biophys Res Commun 259: 476-482.